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80% of colorectal cancers resist immunotherapy—this DNA treatment could help

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  • 2025-06-25 22:23 event
  • 2 months ago schedule
80% of colorectal cancers resist immunotherapy—this DNA treatment could help
A University of Alberta research team has identified a DNA structure that activates the immune system in cancer cells that are usually resistant to immunotherapy, offering hope of new, more effective treatments for colorectal and other cancers.

2.987. How your gut bacteria could help detect pancreatic cancer early

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Whether you had breakfast this morning or not, your pancreas is working quietly behind the scenes. This vital organ produces the enzymes that help digest your food and the hormones that regulate your metabolism. But when something goes wrong with your pancreas, the consequences can be devastating.

2.988. Some people are turning to nicotine gum and patches to treat long COVID brain fog

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Some people with long COVID are turning to an unlikely remedy: nicotine gum and patches. Though typically used to quit smoking, nicotine is now being explored as a possible way to ease symptoms such as brain fog and fatigue.

2.989. More than half of US teens have had at least one cavity, but fluoride programs in schools help prevent them

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Programs delivering fluoride varnish in schools significantly reduce cavities in children. That is a key finding of our recently published study in the American Journal of Preventive Medicine.

2.990. How the brain amplifies perception of pain from multiple sources

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When pain strikes from multiple sources—such as a paper cut followed by contact with hot water—the experience can feel disproportionately intense. But is this agony merely additive, or does the brain integrate these signals in a way that amplifies suffering?

2.991. Mitochondria can sense bacteria and trigger your immune system to trap them

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Mitochondria have primarily been known as the energy-producing components of cells. But scientists are increasingly discovering that these small organelles do much more than just power cells. They are also involved in immune functions such as controlling inflammation, regulating cell death and responding to infections.

2.992. Electrochemical catheter hub could prevent bloodstream infections

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Washington State University and Mayo Clinic researchers have developed an electrochemical catheter hub that could someday help prevent deadly central line-associated bloodstream infections (CLABSIs) that annually kill thousands of people around the world.

2.993. Botox mitigates debilitating dry mouth in prostate cancer patients receiving radiopharmaceutical therapy

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Salivary gland toxicity from radiopharmaceutical therapy—particularly from alpha-emitting therapies like 225Ac-PSMA—is a critical dose-limiting side effect, often leading to debilitating dry mouth. Prior attempts to alleviate dry mouth using cold packs, single anticholinergics, or external cooling have shown minimal protective benefit.

2.994. Cold drinks may trigger irregular heartbeat in some people with Afib

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There's nothing better than an ice cold drink on a hot day but imagine this—you're enjoying a refreshing iced tea, and suddenly, your heart starts racing erratically. You might think—"maybe its the caffeine"—until it happens again, this time with a lemonade. It may sound strange, but for some people, cold drinks may be to blame for sudden episodes of atrial fibrillation (Afib), a common heart rhythm disorder.

2.995. What does science say about pet allergies?

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If spending time around dogs or cats makes your eyes water, your nose run, your skin itch or your breathing difficult, you're not alone.

2.996. 80% of colorectal cancers resist immunotherapy—this DNA treatment could help

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A University of Alberta research team has identified a DNA structure that activates the immune system in cancer cells that are usually resistant to immunotherapy, offering hope of new, more effective treatments for colorectal and other cancers.

2.997. Critical brain link could explain how Alzheimer's takes hold

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A crucial link between the brain's cleaning system and deterioration of neurons associated with Alzheimer's disease has been discovered by University of Queensland researchers.

2.998. North Carolina confirms its first measles case

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North Carolina has its first case of measles this year, the Department of Health and Human Services confirmed Tuesday.

2.999. AI tool can interpret echocardiograms in minutes

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Cardiologists use echocardiography to diagnose a range of functional or structural abnormalities of the heart. Using more than 100 videos and images that capture different parts of the heart, echocardiographers make dozens of measurements, such as the heart's size and shape, ventricle thickness, and the movement and function of each heart chamber, to assess patient heart health.

3.000. Public health officials confirm state's first human West Nile case of the year

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The first human case of West Nile virus in Illinois has been confirmed by the U.S. Centers for Disease Control, according to the Illinois Department of Public Health.

3.001. Why NICE was right to say no—for now—to new Alzheimer's drugs

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The UK's National Institute for Health and Care Excellence (NICE) has declined to recommend two new Alzheimer's drugs for routine NHS use in England. While disappointing for some families affected by dementia, this decision reflects a cautious and evidence-based approach that protects patients and public funds.

3.002. How diverse brain cells reach a decision together

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Every decision begins invisibly. Long before someone acts, the brain is already hard at work gathering evidence, weighing options, and gradually committing to a choice. But even when faced with the same evidence, people can arrive at different outcomes, especially when the decision is difficult. Two different drivers in rush hour traffic, for example, see the same congested road, yet one might speed up to merge while another cautiously brakes.

3.003. Can targeted payment adjustments help solve the infectious disease physician shortage?

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A new analysis by researchers from the Harvard Pilgrim Health Care Institute examines the first Centers for Medicare and Medicaid Services (CMS) add-on code targeting a single physician specialty: infectious disease (ID). The measure is a significant departure from the agency's past strategies, with the potential to combat the growing shortage of ID physicians and broader implications for physician reimbursement and health care delivery, according to the authors.

3.004. Updated COVID vaccine reduces risk of severe illness and death, especially for high-risk adults

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A new multi-state study led by the Centers for Disease Control and Prevention's (CDC) VISION Network—including Regenstrief Institute—has provided the most comprehensive assessment to date of the effectiveness of 2023–2024 COVID-19 vaccines among adults in the U.S. during the XBB and JN.1 omicron subvariant waves.

3.005. Immune cells promoting tumor growth? How dying cancer cells turn their enemies into allies

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Scientists at Nagoya University in Japan studied what happens when macrophages—a type of immune cell—encounter dying cancer cells in tumors and discovered a mechanism that accelerates tumor growth. When cancer cells begin to die within tumors, they expose signals on their surface that indicate they are dying.

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