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A new framework for understanding and tackling CAR T toxicities

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  • 2025-07-16 21:20 event
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A new framework for understanding and tackling CAR T toxicities
Immunotherapy using CAR T cells is finding ever more applications. In addition to their use in the treatment of blood and lymphatic cancers, CAR T cells are now also being investigated for solid tumors and various autoimmune diseases. With the growing number of indications and patients, the issue of side effects associated with this innovative therapy is becoming even more pressing.

1.771. Gut bacteria metabolite linked to early atherosclerosis and potential new treatments

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Cardiovascular disease is the leading cause of death worldwide and often originates in atherosclerosis, a chronic condition in which inflammation and fat deposits cause arteries to harden and narrow. Although clinical practice already targets causal factors like cholesterol, hypertension, and smoking, detecting atherosclerosis in its early stages remains challenging.

1.772. Will RFK Jr.'s push for psychedelic therapy help or hamper the emerging field?

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For decades, proponents of psychedelic drugs have come to Washington with a provocative message: Illegal, mind-altering substances like LSD and ecstasy should be approved for Americans grappling with depression, trauma and other hard-to-treat conditions.

1.773. How a drone delivering medicine might just save your life

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Drones can deliver pizza, and maybe one day your online shopping. So why not use them to deliver urgent medicines or other emergency health-care supplies?

1.774. How safe are the chemicals in sunscreen? A pharmacology expert explains

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Last week, the Therapeutic Goods Administration (TGA) released its safety review of seven active ingredients commonly used in sunscreens.

1.775. Omicron strain BA.2.86 emergence defies natural explanation

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The omicron BA.2.86 lineage of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, is known to have emerged suddenly with approximately 30 genetic mutations in the spike protein, similar to the earlier omicron BA.1 variant. However, BA.2.86 was not sufficiently infectious to become a dominant strain, and it was only after further mutating into the JN.1 variant that a significant surge in infections began to occur.

1.776. Bacteria from cows show promising results in treating MRSA infections

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Imagine two people talking over a walkie-talkie set. Successful communication depends on them being tuned to the same frequency. If others try to communicate nearby, interference can occur, and important messages may be lost.

1.777. Who really hears the best? Visuals sway some musicians more than others

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When we listen to a symphony, a jazz performance, or a pop song, we naturally tend to assume that our ears are the primary judges of quality. For many people, music is primarily an auditory experience, and they instinctively believe that the true essence of a musical performance lies in factors such as its acoustic fidelity, proper intonation, or rhythmic precision.

1.778. Calls for an increase of trauma-informed care for child medical procedures

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The psychological and emotional harm of restraining a child during a medical procedure is causing more trauma than necessary.

1.779. Discovery could battle Alzheimer's by boosting blood flow to brain

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New University of Virginia School of Medicine research suggests an unexpected way doctors may be able to improve blood flow to the brain to battle Alzheimer's and other neurodegenerative diseases.

1.780. A new framework for understanding and tackling CAR T toxicities

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Immunotherapy using CAR T cells is finding ever more applications. In addition to their use in the treatment of blood and lymphatic cancers, CAR T cells are now also being investigated for solid tumors and various autoimmune diseases. With the growing number of indications and patients, the issue of side effects associated with this innovative therapy is becoming even more pressing.

1.781. Telehealth works but rules need changing

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With its services skyrocketing during the COVID-19 pandemic, telehealth—where medical services are delivered by phone or video call—has become a mainstay of health care systems in Australia and other countries around the world.

1.782. Cardiologist helps nurses eat healthier and take better care of themselves

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Nurses are charged with other people's health, but they often do not prioritize their own.

1.783. No increased risk of childhood cancer near UK nuclear sites, study finds

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Children living near nuclear power stations in the U.K. are not at increased risk of childhood cancers, according to a new analysis.

1.784. Scientists develop tool that improves tissue cancer analysis

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Researchers have developed a powerful new tool that makes it easier to study the mix of cell types in human tissue, which is crucial for understanding diseases such as cancer.

1.785. Deadly flesh-eating bacteria in Florida waters: Vibrio cases decline; danger persists

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Four people in Florida have died this year from Vibrio vulnificus, a rare flesh-eating bacterium found in warm, brackish seawater, among 11 confirmed cases, according to state health officials.

1.786. Deafness and loneliness accelerate cognitive decline in older adults, findings reveal

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Isolation, communication difficulties, reduced alertness—hearing impairment or loss is a real challenge in daily life. Over time, it can also become a risk factor for cognitive decline. A team from the University of Geneva (UNIGE) analyzed data from 33,000 older adults across Europe to examine the combined impact of hearing loss and loneliness on memory.

1.787. Study shows how body image bullying affects teenage girls' brains

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University of the Sunshine Coast researchers have shown, for the first time in Australia, what happens in the brain of adolescent girls when they see someone being subjected to body image-related cyberbullying (BRC).

1.788. An aggressive childhood cancer case opens new avenues for advanced cell therapies

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Although relatively rare, many childhood cancers remain life-threatening and lack effective personalized treatments. Rhabdoid tumors are among these fatal cancers and can develop in various tissues and organs. Approximately 12 new cases of this extremely aggressive cancer that typically appears before the age of two are diagnosed in Spain each year.

1.789. Doulas, once a luxury, are increasingly covered by Medicaid—even in GOP states

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As a postpartum doula, Dawn Oliver does her best work in the middle of the night.

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