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Patients with heart failure and atrial fibrillation (AF) at the time of mitral transcatheter edge-to-edge repair (M-TEER) for severe mitral regurgitation are more than twice as likely to die or be rehospitalized for heart failure, compared to patients without AF.
Controlling the activity of specific genes in the laboratory through the editing of their epigenetic marks is now a reality thanks to the CRISPR technology. A team from the Josep Carreras Leukemia Research Institute has demonstrated that it is possible to precisely control the methylation status of one of the key genes involved in controlling the inflammatory response (IL1RN), thereby modifying how the cell responds to external stimuli. With this finding, the development of innovative therapies based on epigenome editing to tackle inflammatory diseases, including myeloid leukemia, is one step closer.
Peter Mac researchers have discovered a powerful new drug combination that could offer hope to children and adults with certain subtypes of acute myeloid leukemia (AML).
New research from the University of Sydney reveals surgically implanted spinal cord stimulators—a common treatment for lower back pain which aims to disrupt pain signals traveling to the brain—are costly and putting patients at risk of needing ongoing surgical interventions to fix complications, with a quarter receiving the treatment going on to require corrective surgery.
A new antibody shot that protects babies against RSV infection could be struggling to gain traction, researchers report.
A major international study led by Liverpool School of Tropical Medicine (LSTM) has confirmed that the drug used to prevent malaria in pregnancy continues to protect babies' health, despite malaria parasites developing high levels of drug resistance.
Doctors and genetic researchers at The University of Manchester have discovered that changes in a gene leads to severe nerve damage in children following a mild bout of infection.
Excessive alcohol consumption causes alcoholic liver disease, and about 20% of these cases progress to alcohol-associated steatohepatitis (ASH), which can lead to liver cirrhosis and liver failure. Early diagnosis and treatment are therefore extremely important.
A scientific team supported in part by the National Institutes of Health (NIH) has developed a new, ultra-high-resolution brain imaging system that can reconstruct microscopic brain structures that are disrupted in neurological and neuropsychiatric brain disorders. The new system is a significant advance over conventional magnetic resonance imaging (MRI) scanners that cannot visualize these tiny but clinically important structures.
A discovery with major implications for cancer treatment has been made by a team of researchers from Rensselaer Polytechnic Institute (RPI), the University of Nebraska Medical Center (UNMC), University of Binghamton, and SUNY College of Environmental Science and Forestry.
New research has found that delivering a stronger form of the tuberculosis vaccine directly to the lungs can help generate protective immune cells to help fight the disease. The research is published in the journal Mucosal Immunology.
A specially engineered antibody that can accurately deliver RNA treatments into hard-to-reach and hard-to-treat tumors significantly improved survival and reduced tumor sizes in animal models, according to a study reported in Science Translational Medicine.
Artificial intelligence (AI) models trained on large datasets are increasingly seen as the key to unlocking personalized treatments for brain disorders. An important bottleneck for scaling AI is the cost of data collection. This raises a fundamental dilemma: is it more cost-effective to scan more people for a short time, or fewer people for longer?
A group led by the Department of Neurosurgery at the Brain Research Institute, Niigata University, has successfully treated a patient with a brainstem glioma harboring a rare IDH2 mutation. The case report was published online in the journal Frontiers in Oncology.
Cognitive impairment is increasing globally. All stages of dementia are marked by declines in memory and executive function. Previous research has examined whether micronutrient levels may relate to cognitive resilience.
Scientists have used an AI model to reassess the results of a completed clinical trial for an Alzheimer's disease drug. They found that the drug slowed cognitive decline by 46% in a group of patients with early-stage, slow-progressing mild cognitive impairment—a condition that can progress to Alzheimer's.
Two university hospitals are pioneering new ways to expand lifesaving heart transplants for adults and babies—advances that could help recover would-be heart donations that too often go unused.
17 July 2025, Cairo, Egypt – The Regional Health Alliance (RHA) convenes today to accelerate efforts to improve maternal, newborn and child health and support immunization and polio eradication across the World Health Organization (WHO) Eastern Mediterranean Region. The meeting will gather representatives from nine UN agencies and six priority countries – Afghanistan, Djibouti, Pakistan, Somalia, Sudan and Yemen. Hosted by WHO Regional Office for the Eastern Mediterranean, the one-day meeting aims to strengthen support for Member States as they implement national strategies to reduce maternal, newborn and child mortality, eradicate polio and boost immunization coverage through the Expanded Programme on Immunization. Recent data indicate that 60 countries globally are not on track to meet the Sustainable Development Goal (SDG) targets on under-5 mortality, and 65 are off track for the neonatal mortality target. In 2023, the six priority countries accounted for almost 85% of under-5 deaths (694 000 out of 812 000) in the Eastern Mediterranean Region and recorded some of the highest maternal mortality rates globally, ranging from 155 to 563 per 100 000 live births. Participants will discuss ways to enhance efforts, renew commitment and increase investment in maternal, newborn and child health to help countries achieve the SDG targets adopted by UN Member States in 2015, including reducing maternal mortality to less than 70 per 100 000 live births and ending preventable deaths of newborns and children under 5 by 2030. Recognizing the urgent need for action, WHO, the United Nations Children’s Fund (UNICEF) and the United Nations Population Fund (UNFPA) are collaborating Read more...
17 July 2025, Cairo, Egypt – Today, the World Health Organization (WHO) Regional Office for the Eastern Mediterranean joined with mental health partners and stakeholders to launch the Regional Coalition for Mental Health Promotion and Substance Use Prevention. The Coalition will provide a platform to align strategies and maximize collective impact. Stakeholders will be able to transform how mental health, psychosocial support and substance use are addressed across the Region and facilitate the urgently needed shift from stigmatization to empowerment, punishment to prevention, isolation to integration and fragmentation to coordinated, impactful action. Tackling mental health conditions and substance use poses a major challenge at both the global and regional level. In today’s context of shrinking resources and growing needs, unified strategic actions are required. No single sector or agency can address the pressing challenges alone. The Coalition brings together civil society actors working on the frontlines of mental health and substance use, many led by people who have been directly affected. Their work spans prevention, rehabilitation, advocacy, service delivery and policy reform. People with lived experience are a vital resource and must be engaged with as equal partners and leaders, not as beneficiaries or symbols. Mental health conditions and substance use disorders exact a devastating toll across the Eastern Mediterranean Region – on individuals, families and communities. One in 6 people in the Region lives with a mental health condition. Substance use is on the rise, with 6.7% of adults affected – above the global average – of whom only a fraction receive treatment. Read more...