A widening divide: Global health research risks drifting away from real-world disease needs, study warns

Standard concurrent chemoradiotherapy (CCRT) for cervical cancer achieves disease-free survival (DFS) in approximately 70% of patients with locally advanced disease; however, nearly 30% still experience recurrence or metastasis.

The U.S. Food and Drug Administration has approved Leqembi Iqlik, a subcutaneous version of lecanemab, for weekly maintenance after the 18-month intravenous (IV) phase.

Scientists at CSIRO, Australia's national science agency, have identified a new virus in Australian flying foxes, a discovery that strengthens Australia's preparedness against emerging infectious diseases.

From 2021 to 2024, 59.0% of overdose deaths involved stimulants, according to research published in the Aug. 28 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

An international team has created the first comprehensive reference measurements for blood vessel stiffness in healthy young people, a step that could give pediatric and adolescent clinics a multi-decade head start in spotting and treating cardiovascular disease risk.

A new generation of CAR T cell therapy is bringing hope in the fight against cancer, targeting not only blood cancers but also solid tumors such as ovarian and breast cancer. Fraunhofer researchers teamed up with the University Hospital of Würzburg to streamline the complicated process of manufacturing these therapies as well. This could make them much more available.

A study published in The Annals of Thoracic Surgery suggests that prenatal detection of congenital heart disease (CHD) has improved in recent years, largely due to advances in ultrasound screening practices.

A comprehensive study shows that California's CA Bridge program has successfully implemented opioid-use disorder treatment services across more than 80% of the state's emergency departments, reaching over 165,000 patients and providing nearly 45,000 instances of buprenorphine treatment from July 2022 through December 2023 alone.

Acute myocardial infarction and acute kidney injury are life-threatening conditions caused by ischemia, resulting from reduced or blocked blood flow to organs. Although early restoration of blood flow improves survival, many patients still develop chronic heart or kidney failure. The mechanisms driving this transition from acute tissue injury to chronic dysfunction remain poorly understood, and effective treatments are lacking.

In a new study, researchers from the University of Chicago discovered that zeaxanthin, a plant-derived carotenoid best known for protecting vision, may also act as an immune-boosting compound by strengthening the cancer-fighting activity of immune cells. The findings, which are published in Cell Reports Medicine, highlight the potential of zeaxanthin as a widely available supplement to improve the effectiveness of cancer immunotherapies.

A Mayo Clinic study finds that a shortened, less intense course of radiation and chemotherapy after minimally invasive surgery for HPV-positive oropharyngeal squamous cell carcinoma (HPV+OPSCC) results in less toxicity, substantially lowering the rates of treatment-related side effects while maintaining high cure rates. The findings were published in The Lancet Oncology.

A study in China covering 42,703 families affected by rare diseases across 32 provincial regions of China has established a new diagnosis framework for rare diseases. It offers new hope to millions of patients struggling with delayed or incorrect diagnoses.

Faced with a worsening drug crisis, policymakers in recent years have made it much easier for doctors to prescribe the highly effective opioid addiction treatment buprenorphine. However, many patients may still struggle to find pharmacies carrying the treatment, finds new research led by the USC Schaeffer Center for Health Policy & Economics.

Nearly three out of four adults fear going to the dentist, according to a study published in the Journal of the American Dental Association.

A simple brainwave test developed at the University of Bath has been shown to detect signs of memory impairment linked to Alzheimer's disease years before clinical diagnosis is typically possible.

A research team at UCLA, led by Professor Aydogan Ozcan, has introduced BlurryScope, a compact, cost-effective scanning microscope that combines simple optical hardware with advanced deep learning algorithms to assess HER2 status in breast cancer tissue samples.

Stress on college students can be palpable, and it hits them from every direction: academic challenges, social pressures and financial burdens, all intermingled with their first taste of independence. It's part of the reason why anxiety and depression are common among the 19 million students now enrolled in U.S. colleges and universities, and why incidents of suicide and suicidal ideation are rising.

A research team at Saarland University has demonstrated in a clinical study that a widely used anti-allergy nasal spray containing the active ingredient azelastine can significantly reduce the risk of infection with the SARS-CoV-2 virus. The results of the placebo-controlled trial involving 450 healthy participants have now been published in JAMA Internal Medicine.