A year of dieting with non-sugar sweeteners shows weight loss can stay lost

FX-909, a first-in-class investigational oral small molecule inhibitor of peroxisome proliferator-activated receptor gamma (PPARG), showed early signs of clinical benefit in patients with advanced urothelial carcinoma, according to results from a phase I clinical trial presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held October 22–26 in Boston.

Too tired to drive? What seems like a harmless yawn can quickly become a risk as dangerous as drunk driving. According to a 2025 survey from the American Academy of Sleep Medicine, 41% of U.S. adults have felt so sleepy while driving that it affected their ability to drive safely, including half of men (50%) and one-third of women (33%).

Among survivors of drug overdose, fewer than half visited the emergency department, according to a study published online Oct. 16 in JAMA Network Open.

A University of Alberta research team is shedding much-needed light on cancer cachexia, a severe muscle-wasting syndrome linked to up to a third of cancer deaths.

Triple-negative breast cancer is one of the most aggressive cancers. The name tells the story: It lacks the three main targets that make other types of breast cancers more treatable with powerful therapies.

More than 50% of lung-transplant recipients experience a rejection of their new lung within five years of receiving it, yet the reason why this is such a prevalent complication has remained a medical mystery.

The "2025 American Heart Association Guidelines for Cardiopulmonary Resuscitation (CPR) and Emergency Cardiovascular Care (ECC)," published today in the journal, Circulation, marks the first full revision of lifesaving resuscitation guidance since 2020. Among the updates are expanded recommendations for managing choking and suspected opioid overdose, in addition to other lifesaving interventions.

The maker of Tylenol is urging U.S. health regulators not to add an autism warning label to it and other pain-relievers containing acetaminophen, calling the request "unsupported by the scientific evidence and legally and procedurally improper."

More than 6 million eggs sold under the Black Sheep Egg Company brand have been recalled after federal officials detected multiple strains of salmonella at one of its processing facilities.

Findings from a randomized and blinded clinical trial investigating repeated ketamine infusions for treating depression have revealed no extra benefit from ketamine when added to standard care for people admitted to hospital for depression.

By analyzing large amounts of data, researchers at Karolinska Institutet have developed a system for classifying individuals into different risk groups for atherosclerosis. The results enable early detection of the disease, which can lead to personalized preventive care.

A new national study, led by MUSC Hollings Cancer Center researcher Trisha Amboree, Ph.D., assistant professor in the MUSC Department of Public Health Sciences, and Jane Montealegre, Ph.D., associate professor of Behavioral Science at The University of Texas (UT) MD Anderson Cancer Center, points to federally qualified health centers (FQHCs) as a powerful—but underused—resource in closing gaps in cervical cancer screening.

Three copies of chromosome 21 cause Down syndrome (DS), and roughly half of children born each year in the United States with DS—approximately 2,600—also have congenital heart defects (CHDs).

When harmful bacteria that cause food poisoning, such as E. coli, invade through the digestive tract, gut cells usually fight back by pushing infected cells out of the body to stop the infection from spreading.

Has a camouflaged athlete running on a dirt road ever shouted health advice through your phone? Sometimes these videos are motivational and get you off the couch to start exercising; sometimes they're educational. But can their advice help us civilians?

Imagine you're at the grocery store, standing before a selection of snacks. Seemingly without thinking, you skip over the rice crackers to pick out a bag of chips.

The termination of thousands of federal grants that fund clinical trials threatens to reverse substantial progress in understanding and treating the health challenges of marginalized populations, particularly children and adolescents who are already underrepresented in research.

New research from UCLA Health reveals that women continue to face barriers in accessing lung transplants compared to men, despite recent national policy changes aimed at making organ distribution more equitable.