AI-informed approach to CAR design enhances bi-specific CAR T cells

An ILAE task force has developed the first international curriculum for epilepsy surgery with the goal of providing global training standards.

A newly published, post-hoc analysis of the landmark FUEL (Fontan Udenafil Exercise Longitudinal) Trial demonstrates that udenafil, a PDE5 inhibitor, significantly improves peak oxygen consumption (peak VO₂) in adolescents with single-ventricle congenital heart disease (SV-CHD) who have undergone the Fontan procedure and have reduced exercise capacity.

NRG Oncology recently reported the results of the phase II/III NRG-BN007 clinical trial showing that combining ipilimumab and nivolumab with radiation therapy (RT) did not improve progression-free survival (PFS) for patients with newly diagnosed MGMT-unmethylated (uMGMT) glioblastoma in comparison to standard RT with temozolomide (TMZ). Accordingly, this trial will not progress to a phase III. These results were recently published in the Journal of Clinical Oncology.

There are more than 1 million people on NHS waiting lists for mental health care in the UK. Many of them have to wait weeks or months before treatment can begin for conditions such as depression and anxiety.

For a few dozen people in the world, the downside of living with a rare immune condition comes with a surprising superpower—the ability to fight off all viruses.

Acute kidney injury occurs frequently and still represents a major clinical challenge due to the lack of a targeted therapy.

Cytomegalovirus (CMV), a common virus in the Herpesviridae family, infects approximately half of all adults in the United States, most of whom experience mild or no symptoms. While the virus usually remains latent in the body, CMV reactivation is more prevalent in immunocompromised individuals, including people with inflammatory bowel disease (IBD). Individuals with IBD are more susceptible to CMV reactivation because of chronic gut inflammation and the use of immunosuppressive medications.

Robert F. Kennedy Jr has spent years railing against food additives, framing them as part of a broader threat to public health. Now, as the US health secretary, his views have taken on new weight.

Many people find that their sleep and moods are linked to the seasons. Those living in temperate zones may feel like hibernating in winter and staying out all night in summer, though even those in the tropics can be affected by changing seasons. That's because we are seasonal animals and adjust our behavior according to cues from the environment.

Researchers have identified a promising new strategy for treating alcohol use disorder (AUD). A novel study found that the dopamine-boosting drug tolcapone increases activity in the prefrontal cortex (PFC) during self-control tasks. Greater activation of the inferior frontal gyrus, part of the PFC, was associated with better behavioral control and reduced alcohol consumption.

A new study, published in Environmental Research, has linked noise levels to depression and anxiety diagnoses. It is the first study of its kind to investigate long-term exposure to traffic noise and mental health in children, adolescents, and young adults.

Many of us have a fraught relationship with sleep. We delay bedtime for precious alone time, we scroll on our phones in bed, we sacrifice weeknight sleep only to catch marathon Z's on the weekend.

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have shown that 18FDG-PET, an imaging technique widely used to study other conditions, can also be used to monitor atherosclerosis by measuring cellular metabolism within arterial plaques.

Research from scientists at the University of California San Diego School of Medicine has shed new light on an age-old question: what makes the human brain unique? The study is published online in Science Advances.

Clinicians are more likely to indicate doubt or disbelief in the medical records of Black patients than in those of white patients—a pattern that could contribute to ongoing racial disparities in health care. That is the conclusion of a study, analyzing more than 13 million clinical notes, published in the open-access journal PLOS One by Mary Catherine Beach of Johns Hopkins University, U.S.

A modified version of the Dietary Approaches to Stop Hypertension (DASH) diet is effective at lowering glucose in adults with type 2 diabetes, according to a study published online Aug. 5 in Nature Medicine.

A stroke happens when the blood supply to part of the brain is cut off, either because of a blockage (called an ischemic stroke) or bleeding (a hemorrhagic stroke). Around 83% of strokes are ischemic.

Many families find feeding children a constant challenge. A favorite food is suddenly refused, someone is grumpy after a long day, siblings fight at the table.