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Alzheimer's protective mutation works by taming inflammation in the brain

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  • 2025-06-24 00:00 event
  • 2 months ago schedule
Alzheimer's protective mutation works by taming inflammation in the brain
A rare gene mutation that delays Alzheimer's disease does so by damping inflammatory signaling in brain-resident immune cells, according to a preclinical study led by investigators at Weill Cornell Medicine. The finding adds to growing evidence that brain inflammation is a major driver of neurodegenerative disorders such as Alzheimer's—and that it may be a key therapeutic target for these disorders.

3.160. How inflammation drives prostate tumor formation

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Prostate cancer is one of the most common cancers and the second leading cause of cancer-related death in men worldwide. However, the mechanisms controlling the early stages of prostate cancer formation are poorly understood.

3.161. A new national standard for safe, scalable AI in health care

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Duke University School of Medicine researchers have developed two pioneering frameworks designed to evaluate the performance, safety, and reliability of large-language models in health care.

3.162. Researchers can now track listeners' attention using just earbuds and echoes

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In the clamor of a crowded café or the din of a busy street, your brain performs a quiet miracle—tuning into one voice while filtering out the rest. This ability, known as auditory attention, is crucial to how we learn, communicate and connect.

3.163. ADHD link to severe premenstrual disorder uncovered in women

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A new study from a group of scientists led by Queen Mary University of London, published in the British Journal of Psychiatry, found that women with attention-deficit hyperactivity disorder (ADHD) may be at higher risk for premenstrual dysphoric disorder (PMDD).

3.164. Novel mechanism may explain CAR-T therapy resistance in aggressive B-cell lymphoma

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A research team has discovered a previously unknown mechanism that could explain why many patients with aggressive B-cell lymphoma do not respond to CAR-T cell therapy in the long term. The results of the study suggest that combining this innovative treatment with other therapies could further improve its effectiveness.

3.165. Innovative weight loss program for obese patients that need a kidney transplant

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Infection, delayed kidney function, kidney loss and death are all risks associated with kidney transplant surgery in obese patients.

3.166. Common drug shows promise in halting rare blood cancer by restoring tumor suppressor

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Northwestern Medicine scientists have uncovered key details about a group of rare but serious blood disorders, which may help inform potential treatments, according to a study published in the Journal of Clinical Investigation.

3.167. Typos and slang in patient messages can trip up AI models, leading to inconsistent medical recommendations

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A large language model (LLM) deployed to make treatment recommendations can be tripped up by nonclinical information in patient messages, like typos, extra white space, missing gender markers, or the use of uncertain, dramatic, and informal language, according to a study by MIT researchers.

3.168. Post-treatment imaging improves safety and personalizes care in radiopharmaceutical therapy

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Post-therapy imaging and dosimetry significantly enhance patient management, empowering clinicians to make more informed, personalized decisions in radiopharmaceutical therapy. A series of case studies presented at the Society of Nuclear Medicine and Molecular Imaging 2025 Annual Meeting highlights how this approach improves patient outcomes, guides clinical decision-making, and drives meaningful changes in clinical practice. The abstract is published in the Journal of Nuclear Medicine.

3.169. Alzheimer's protective mutation works by taming inflammation in the brain

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A rare gene mutation that delays Alzheimer's disease does so by damping inflammatory signaling in brain-resident immune cells, according to a preclinical study led by investigators at Weill Cornell Medicine. The finding adds to growing evidence that brain inflammation is a major driver of neurodegenerative disorders such as Alzheimer's—and that it may be a key therapeutic target for these disorders.

3.170. Music on the brain: Exploring how songs boost memory

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Music improves mood and memory to such an extent that treatment strategies for diseases like Alzheimer's or dementia sometimes incorporate music. But how music boosts memory remains unclear.

3.171. NZ's changing diet: Māori bread and jackfruit join other new foods in the country's nutritional database

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The latest update to the New Zealand food composition database, a comprehensive collection of nutrient data collated jointly by Plant & Food Research and the Ministry of Health, brings more than just numbers: it adds insights into culturally important foods and their role in diets.

3.172. Five ways to keep teenagers safe by the water

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As temperatures soar around the UK and Ireland due to climate change, warnings about the dangers of drowning are being issued and one Labor MP is calling for water safety lessons to be made compulsory in schools.

3.173. How do I get started in the gym lifting weights?

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So you've never been to a gym and are keen to start, but something's holding you back. Perhaps you don't know what to actually do in there or feel like you'll just look stupid in front of everyone. Maybe you're worried about injuring yourself.

3.174. Food structure shown to play key role in which gut hormones are released

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A new study from Imperial has shown that the physical structure of food influences the hormones released as part of digestion. These hormones include glucagon-like peptide-1 (GLP-1), GIP and PYY, as well as other post-meal responses like blood sugar, insulin and satiety hormones.

3.175. Older northerners struggle with 'alarming' inequalities compared to people from the south

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Older people in the North of England are more likely to be poorer, less healthy, physically inactive, lonely and in poor housing—resulting in millions of pounds of avoidable NHS costs.

3.176. How to prevent tick bites: Five expert tips for summer safety

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It's officially summer, a time for barbecues, the beach—and protecting yourself against the teeny, tiny black-legged deer ticks that cause most Lyme disease cases.

3.177. Teen depression? Study finds clues in screen use and sleep quality

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In this digital era, both kids and adults are often glued to smartphone screens. Digital technology keeps users entertained, connected to friends, and in tune with important news. But some reports suggest that, particularly for adolescents, excessive time on these screens can be linked to mental health problems and even depression.

3.178. Genetic cause for rare childhood brain developmental disorder found

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University of Otago–Ōtākou Whakaihu Waka has led international research uncovering a new genetic cause for a rare developmental disorder that profoundly impacts brain growth and function in children.

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