As pesticides and wildfires rise, kids with cancer need resources

Researchers have provided new insights into how exercise helps lose weight. They discovered a mechanism by which the compound Lac-Phe, which is produced during exercise, reduces appetite in mice, leading to weight loss. The findings appeared in Nature Metabolism.

In almost all solid tumors—i.e. cancers with a solid tissue structure—the detection of tumor cells in the lymph nodes is considered a decisive marker for the progression of the disease. Lymph node involvement has a significant influence on the choice of treatment and the chances of survival for patients.

Nitazenes—a class of highly potent synthetic opioids—are rapidly emerging as a major contributor to the overdose crisis, according to a Pain Medicine review published today by authors from Vanderbilt University Medical Center and the University of Pittsburgh Medical Center.

Scientists have uncovered how lymphatic vessels—the kidney's "plumbing system"—undergo dramatic changes during chronic transplant rejection, becoming structurally disorganized and spreading to unusual parts of the kidney.

Implanting a brain shunt in older people diagnosed with idiopathic normal pressure hydrocephalus (iNPH) is effective in improving their symptoms, a randomized, double-blinded, multi-center patient trial shows.

A diet focused on healthy plant-based foods may lower the risk of type 2 diabetes while reducing greenhouse gas emissions, according to a new study by Solomon Sowah and colleagues from the MRC Epidemiology Unit at the University of Cambridge, United Kingdom, published September 16 in the open-access journal PLOS Medicine.

Previous studies have suggested that children exposed to opioid pain medications while in the womb have higher rates of autism spectrum disorder (ASD) and attention- deficit/hyperactivity disorder (ADHD), but a new study finds that any increased risk could be explained by other factors.

Olympic swimmer Ben Proud has become the first British athlete to join the Enhanced Games—a controversial new event that allows athletes from all over the world to compete using performance-enhancing drugs. The prize money on offer can hit US$1 million (£730,000). But the swimmer, who won a silver medal at last year's Paris Olympics, has sparked sharp criticism from sporting bodies after announcing he would be taking part.

Nearly one in three people have reported serious difficulties in psychologically adapting to life after the COVID-19 pandemic, a new study led by researchers at the University of Hertfordshire has found.

In the brain, it is not only important that nerve cells send signals, but also how quickly they can do so. In order for information to flow smoothly, a kind of biological insulation is necessary. The brain forms specialized cells called oligodendrocytes for this purpose. They coat the long extensions of nerve cells, the axons, with a protective layer of myelin.

Researchers at Children's Hospital of Philadelphia (CHOP) unveiled a novel antibody-drug conjugate (ADC) that shows striking efficacy against cancers that express the anaplastic lymphoma kinase (ALK) protein on the cancer cell surface. The therapy, named CDX0239-PBD, achieved complete and lasting tumor responses in preclinical models of neuroblastoma, rhabdomyosarcoma and colorectal carcinoma, according to findings published in Nature Communications.

A high-sugar, high-fat diet during pregnancy may do more than affect a mom's health—it can also trigger inflammation and gut dysfunction in their children, new research suggests. The study, published in the American Journal of Physiology—Gastrointestinal and Liver Physiology, found that poor maternal nutrition impairs intestinal barrier function in the next generation. The article has been chosen as an APSselect article for September.

German doctors are increasingly prescribing smartphone health apps alongside pills and therapy to patients, marking a growing trend towards digital health care.

Gooder Foods, Inc. is recalling eight lots of its boxed mac and cheese products because they may contain undeclared allergens, federal officials said.

A new study illuminates how some areas of the country have been hit much harder than others by the fentanyl epidemic, which took more than 70,800 lives in 2022 alone.

For most people, swallowing is second nature, but how does it occur, and why do some people have difficulty with it? Researchers at Kyushu University in Japan have started to tackle these questions by developing a mathematical model that recreates the muscle movements of the esophagus that occur during swallowing. The model, reported in Royal Society Open Science, also replicates muscle dynamics seen in various esophageal motility disorders, revealing insights into their underlying causes and opening up new avenues for treatment.

Federal health officials are reviewing safety data on COVID vaccines in pregnant women and children, and may also reconsider recommendations for older adults.

New findings from researchers at UC Irvine show how a simple dietary change that increases fiber intake can reshape gut bacteria to prevent sugar from damaging the liver and causing disease.