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Bystander T cells can enhance antitumor effects of bispecific antibody

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  • 2025-08-07 21:01 event
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Bystander T cells can enhance antitumor effects of bispecific antibody
T-cell redirection therapy using chimeric antigen receptor (CAR) T cells and/or bispecific antibody (BsAb) has been established and become a promising treatment strategy for relapsed/refractory B-cell lymphomas. To further improve their therapeutic efficacy, assessment of their in vivo mechanisms and the ways of sequential approaches are necessary.

482. Human eggs are protected from age-related genetic mutations, mtDNA study finds

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As we age, the genes in our cells accumulate more mutations. This is one of the contributory factors to age-related diseases and the aging process. However, in a new study published in Science Advances, researchers have discovered one exception where genetic mutations don't appear to build up as humans get older—the mitochondrial DNA (mtDNA) of human egg cells in women.

483. The first 25 years of SuperAger research show cognitive decline is not an inevitable part of aging

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For 25 years, scientists at Northwestern Medicine have been studying individuals aged 80 and older—dubbed "SuperAgers"—to better understand what makes them tick.

484. For seniors: The mental health payoff of staying curious

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In a pair of new studies, researchers found that older adults who challenge themselves to learn new things are less likely to experience loneliness or depression, even during times of major upheaval.

485. A parents' guide to keeping kids safe online in the summer holidays

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Parenting over the summer holidays, especially when juggling work and childcare, comes with significant challenges. One of those is screen time and staying safe online.

486. Can I eat instant noodles every day? What does it do to my health?

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Instant noodles are cheap, quick and comforting—often a go-to snack or meal for students, busy workers, families and anyone trying to stretch their grocery budget.

487. Young adults' brain activity shows TV and gaming boost focus, while social media hinders it

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A world-first Swinburne-led study into young adults' brain activity has found that TV and gaming are associated with increased focus, while social media is associated with decreased focus.

488. Breast cancer surgery: Study finds overnight hospital stay not important for older patients

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Women ages 65 and older—including women in their 90s—can safely leave the hospital on the same day as having a mastectomy for breast cancer and are unlikely to suffer post-surgical complications, according to a new pilot study.

489. Medical journal articles with extenders receive more than twice as many views

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An analysis of article views in Taylor & Francis medical journals has revealed that "extenders" can significantly increase readership. Plain language summaries of publications and clinical trial protocols with extenders attracted 144% higher views than those without these supplemental resources.

490. Understanding how young children recognize emotions in music

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Music is a powerful tool for conveying mood, whether heard via a live performance or movie soundtrack, making it an effective medium for understanding how people identify and respond to emotions. Studies have found that children ages 5 to 11 show increasing accuracy in recognizing specific emotions in music.

491. Bystander T cells can enhance antitumor effects of bispecific antibody

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  • medicalxpress.com language

T-cell redirection therapy using chimeric antigen receptor (CAR) T cells and/or bispecific antibody (BsAb) has been established and become a promising treatment strategy for relapsed/refractory B-cell lymphomas. To further improve their therapeutic efficacy, assessment of their in vivo mechanisms and the ways of sequential approaches are necessary.

492. How past trauma drives the brain's response to new stress

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A new study published in the Proceedings of the National Academy of Sciences offers insight into how past stress impacts a person's response to new stress.

493. Review highlights untapped potential of the vaginal microbiome

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The vaginal microbiome is a largely overlooked area of medicine that could dramatically improve outcomes for millions of women, concludes a new review published in Frontiers in Cellular and Infection Microbiology. The study was co-authored by the Medicine and Healthcare products Regulatory Agency (MHRA) in partnership with University of Liverpool researchers.

494. Beyond the band-aid: A career opportunity as a school nurse

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When thinking of nurses, the image that most often comes to mind is one of bustling hospital corridors, emergency rooms, and bedside care. However, one vital role that frequently goes unnoticed is that of the school nurse—a health care professional who plays a crucial part in supporting the physical, mental, and emotional well-being of students every day.

495. Why forgiving yourself is harder than it sounds

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A new study from Flinders University has revealed why forgiving ourselves can be so difficult for some—even when we know it might benefit our mental health.

496. Why letting go of self-blame is tougher than most people expect

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A new study from Flinders University has revealed why forgiving ourselves can be so difficult for some—even when we know it might benefit our mental health.

497. Bubonic plague treatment proven highly effective and safe in world's first trial

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Researchers from the U.K. and Madagascar, in collaboration with Madagascar's health services and national plague program, have conducted the world's first rigorous clinical trial of treatments for bubonic plague.

498. Neighborhoods may hold the key to slowing cognitive decline

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A collaboration between researchers from the Center for Healthy Brain Aging (CHeBA) at UNSW Sydney and the Australian Catholic University (ACU) has found that living in walkable, green, and well-connected neighborhoods—especially those with access to public transport, commercial services, and blue or green spaces—may help protect against memory and cognitive decline.

499. The ancient origins of the addiction-prone mind—and what it means for us today

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Why do so many people struggle to stop drinking, quit smoking, or resist endless scrolling on their phones? Addiction touches millions of lives, yet it's often misunderstood as a personal weakness or moral failing. In reality, addiction is rooted in the ancient architecture of the human brain.

500. Natural maple polyphenol found to inhibit tooth decay bacteria in new study

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A new study in the journal Microbiology Spectrum highlights the potential of using a natural compound from maple to combat the bacteria responsible for tooth decay: Streptococcus mutans.

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