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CD82 protein may hold key to stopping deadly blood vessel leakage in multi-organ failure

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  • 2025-09-19 03:37 event
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CD82 protein may hold key to stopping deadly blood vessel leakage in multi-organ failure
A new study from the University of Oklahoma reveals how a little-understood protein, CD82, contributes to blood vessel leakage, a process that initiates inflammation but becomes dangerous when it occurs during severe inflammatory diseases such as sepsis, acute respiratory distress syndrome and COVID-19.

1. Severe pregnancy sickness raises risk of mental health conditions by over 50%, study finds

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The largest study on pregnant women with excessive nausea and vomiting (hyperemesis gravidarum) has identified increased risks of numerous neuropsychiatric and mental health outcomes. The study is published in the journal The Lancet Obstetrics, Gynaecology, & Women's Health.

2. Process for dealing with sexual misconduct by UK doctors requires major reform, say experts

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The current process for managing sexual misconduct perpetrated by doctors in the UK requires major reform, say experts in The BMJ.

3. Study: Tirzepatide improves blood sugar control in children with poorly controlled type 2 diabetes

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New research shows that the diabetes/obesity medication tirzepatide can cause clinically meaningful improvements in blood sugar control and weight loss in children and adolescents with type 2 diabetes aged 10–17 years whose diabetes and weight are inadequately controlled with an existing treatment regimen of metformin, insulin, or both.

4. Estimates predict over 4 million missing people who would be alive in 2025 if not for inadequate type 1 diabetes care

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The global type 1 diabetes (T1D) burden continues to increase rapidly, driven by rising cases, aging populations, improved diagnosis and falling death rates, according to the results of a new modeling study presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD), Vienna (15–19 Sept).

5. Study reports potential effects of verapamil in slowing progression of type 1 diabetes

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New research (the Ver-A-T1D trial) presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) (Vienna, 15–19 September) shows that slow-release (SR) verapamil (360mg daily) could have a potential effect on beta-cell function in adults with newly diagnosed type 1 diabetes.

6. Fresh hope for type 1 diabetes as daily pill that slows onset confirms promise at two-year follow-up

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In 2023, the groundbreaking Australian BANDIT (Baricitinib in New Onset Type 1 Diabetes) trial reported that a daily pill of baricitinib, commonly prescribed for rheumatoid arthritis and alopecia, could safely preserve the body's own insulin production and slow the progression of type 1 diabetes (T1D) in people recently diagnosed with the condition.

7. Old drug, in a low dose, safe and effective in preventing progression of type 1 diabetes in children and young people

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New research presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15–19 September) and published simultaneously in The Lancet shows that a much lower dose than previously thought of the old immunomodulatory drug anti-thymocyte globulin (ATG) is safe and effective in preventing progression of type 1 diabetes (T1D) in young people.

8. Better women's health messaging can fight cancer, save lives

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Cervical cancer is the fourth-most common cancer among women globally, according to the World Health Organization. It accounted for 660,000 new cases and 350,000 deaths in 2022.

9. Microplastics linked to impaired bone health

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The production and use of over 400 million tons of plastic each year has polluted beaches, rivers, and even the deepest parts of the ocean, reaching depths of up to 11,000 meters. In addition to visible environmental impacts, plastic contributes to climate change. It is estimated that plastic production generates 1.8 billion tons of greenhouse gases per year. Scientific evidence also suggests that using plastic materials in everyday life has impacted human health.

10. CD82 protein may hold key to stopping deadly blood vessel leakage in multi-organ failure

  • 2 hours ago schedule
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A new study from the University of Oklahoma reveals how a little-understood protein, CD82, contributes to blood vessel leakage, a process that initiates inflammation but becomes dangerous when it occurs during severe inflammatory diseases such as sepsis, acute respiratory distress syndrome and COVID-19.

11. Shape-shifting material could transform future of implantable and ingestible medical devices

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Researchers led by Rice University's Yong Lin Kong have developed a soft but strong metamaterial that can be controlled remotely to rapidly transform its size and shape.

12. Timing last evening meals is critical for people with prediabetes, study suggests

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The way glucose is regulated at night plays a key role in fasting glucose levels the next morning, when blood sugar is expected to be at its lowest. This indicator is particularly important in people with dysglycemia, which is characterized by abnormal glucose levels. However, little research has been done in this area.

13. Social risks can accumulate in specialized psychiatric care, as complex life situations go unnoticed

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Patients in specialized psychiatric care face a variety of social risks that are intertwined, according to a new study from the University of Eastern Finland published in Nordic Social Work Research. Social risks tend to accumulate among the most vulnerable segments of the population. They include, for example, financial difficulties, housing challenges and violence.

14. 'Rhythm beats volume': How the brain keeps the world looking familiar

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The brain is famously plastic: Neurons' ability to change their behavior in response to new stimuli is what makes learning possible. And even neurons' response to the same stimuli changes over time—a phenomenon known as representational drift. Yet our day-to-day perception of the world is relatively stable. How so?

15. Q&A: Combination therapy shows promise for overcoming treatment resistance in glioblastoma

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Rakesh Jain, Ph.D., director of the Edwin Steele Laboratories for Tumor Biology in the Department of Radiation Oncology at Massachusetts General Hospital and Andrew Werk Professor of Radiation Oncology at Harvard Medical School, is senior and corresponding author of a new paper in Proceedings of the National Academy of Sciences, "Wnt Inhibition Alleviates Resistance to Anti-PD1 Therapy and Improves Anti-Tumor Immunity in Glioblastoma."

16. Researchers uncover a key protein and a promising strategy to prevent bone damage from steroids

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A new study from UC Davis Health researchers reveals a promising new way to treat various bone loss conditions, including age-related osteoporosis.

17. Breathing interruptions after seizures may be risk factor for unexpected death in epilepsy patients

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Epilepsy patients who experience breathing interruptions after a seizure may be at a higher risk of sudden unexpected death later in life, according to researchers at UTHealth Houston.

18. Cerebral malaria: New study shows how parasite opens the way to the brain

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Cerebral malaria kills 1 out of 5 children that suffer from it, and causes long-term disabilities in half of the survivors. Malaria is caused by the parasite Plasmodium falciparum, which reproduces in our red blood cells and then breaks out of them to continue infecting new cells. Once the parasite makes it to the blood–brain barrier (BBB), a structure that protects the brain from harmful substances, it is able to damage it, causing severe complications.

19. Elevating blood pressure after spinal cord injury fails to improve recovery, study finds

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Spinal cord injury is one of the leading causes of long-term disability worldwide, often impacting young people who face a lifetime of physical and neurological challenges ahead. A new study questions a widely accepted treatment strategy in the critical first days after injury, findings that could reshape ICU protocols and improve patient outcomes.

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