Certain dietary fats linked to more severe, hard-to-treat asthma in children

Gastrointestinal stromal tumors (GISTs) are the most common type of sarcoma, often driven by mutations in the KIT or PDGFRA genes. Tyrosine kinase inhibitors (TKIs) like imatinib have been the cornerstone of treatment, but most patients eventually develop resistance due to secondary mutations, leading to disease progression and limited survival.

Peptidyl-arginine deiminase 2 (PAD2) enzyme converts arginine amino acid residues in histone proteins into citrulline groups and promotes tumor cell proliferation in pancreatic ductal adenocarcinoma, report researchers from the Institute of Science Tokyo, Japan. Administration of PAD inhibitors reduced PRUNE1 expression and suppressed tumor cell proliferation in both pancreatic cancer cell lines and mouse models. The study thus lays the foundation for future anticancer therapies targeting PAD2 enzymatic activity.

As much as 80% of young people from the lowest social levels drop out of sports during adolescence. "Two-thirds from the highest socio-economic class drop out, three-quarters from the middle class, while from the lowest class, 4 out of 5 drop out during adolescence," says Erik Grasaas at UiA.

U.S. regulators approved updated COVID-19 shots Wednesday but limited their use for many Americans—and removed one of the two vaccines available for young children.

U.S. regulators approved updated COVID-19 shots Wednesday but limited their use for many Americans—and removed one of the two vaccines available for young children.

A pioneering study by researchers from Finland and the UK has demonstrated for the first time that myocardial infarction may be an infectious disease. This discovery challenges the conventional understanding of the pathogenesis of myocardial infarction and opens new avenues for treatment, diagnostics, and even vaccine development.

The eye, like most organs, has an intricate plumbing system. Pressure builds when drainage is impaired, and this condition—glaucoma—can cause irreversible vision loss. Certain popular anti-inflammatory eye medications that contain steroids can in some cases compound the problem, although scientists have been at a loss to understand why.

Researchers at the Nanoscience Initiative at the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have made a breakthrough in the fight against viral diseases.

A new study by researchers at Baylor College of Medicine brings hope for a more personalized approach to treating estrogen receptor-positive (ER+) breast cancer, the most common type of this cancer. The team identified a biomarker in preclinical ER+ breast cancer models that indicates that the tumor is more likely to respond to treatment with CDK4/6 inhibitors.

A new survey-based study suggests that the "unhappiness hump"—a widely documented rise in worry, stress, and depression with age that peaks in midlife and then declines—may have disappeared, perhaps due to declining mental health among younger people. David Blanchflower of Dartmouth College, U.S., and colleagues present these findings in the open-access journal PLOS One.

Insomnia patients taking cannabis-based medical products reported better quality sleep after up to 18 months of treatment, according to a study published in PLOS Mental Health by Arushika Aggarwal from Imperial College London, U.K., and colleagues.

Breathwork while listening to music may induce a blissful state in practitioners, accompanied by changes in blood flow to emotion-processing brain regions, according to a study published in the open-access journal PLOS One by Amy Amla Kartar from the Colasanti Lab in the Department of Clinical Neuroscience at Brighton and Sussex Medical School, U.K., and colleagues.

A new study of young adults has strongly linked better sleep quality with better mental well-being, with fruit and vegetable consumption and physical activity also strongly associated with psychological well-being. Perhaps surprisingly, the findings also suggest that boosting fruit and vegetable intake could potentially help mitigate the effects on well-being after a poor night's sleep.

An international research team led by UCL, Great Ormond Street Hospital, and KU Leuven is using 3D-printing and nanodiamonds to design treatments that could help babies repair their damaged lungs while still in the womb. The new research is published in the American Journal of Respiratory and Critical Care Medicine.

Certain brain cells are responsible for coordinating smooth, controlled movements of the body. But when those cells are constantly overactivated for weeks on end, they degenerate and ultimately die. This new observation made by scientists at Gladstone Institutes may help explain what goes awry in the brains of people with Parkinson's disease.

Inside every human brain lies a detailed map of the body, with different regions dedicated to different body parts—the hands, lips, feet and more. But what happens to this map when a body part is removed?

Researchers at Karolinska Institutet have discovered that mantle cell lymphoma (MCL), a rare and aggressive type of blood cancer, is already highly diverse at the time of diagnosis and continues to evolve in unique ways in each patient. The work is published in the journal Cell Reports Medicine.

A procedure which uses living heart valves may have expanded application as a treatment for various types of pediatric heart valve conditions.