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Diagnostic tool enables rapid leukemia subtype classification

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  • 2025-09-22 23:38 event
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Diagnostic tool enables rapid leukemia subtype classification
Researchers at Dana-Farber Cancer Institute have developed a diagnostic tool that could transform the way acute leukemia is identified and treated. The tool, called MARLIN (Methylation- and AI-guided Rapid Leukemia Subtype Inference), uses DNA methylation patterns and machine learning to classify acute leukemia with speed and accuracy. This tool has the potential to significantly improve patient care by allowing faster and more precise treatment decisions.

16. Blood and ultrasound biomarkers help predict outcomes after liver transplantation

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Over 1500 people in Norway have had a liver transplantation. But how can doctors know which patients need extra follow-up or additional treatment so that as many as possible can live a long life afterward?

17. Exposure to gun violence is associated with insufficient sleep in teens

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New research led by Mass General Brigham researchers reveals an association between insufficient sleep and the witnessing of neighborhood violence by adolescents. Based on nationwide survey data from more than 40,000 teenagers, the study also showed that individuals who slept less than the recommended 8–10 hours per night were more likely to engage in violent behaviors, such as carrying weapons or fighting. Results are published in SLEEP.

18. Study finds wrist cooling represents a promising approach for managing hot flashes

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Hot flashes, which are sudden, temporary intense sensations of body warmth, often accompanied by flushing and sweating during the day and night (night sweats), are referred to as vasomotor symptoms (VMS). These VMS are associated with sleep disturbances, cognitive dysfunction, severe fatigue, increased pain severity and decreased quality of life. Hot flashes affect up to 80% of women going through the menopause transition, 80% of men with prostate cancer undergoing or after completion of androgen deprivation therapy and 50–80% of breast cancer patients receiving hormone deprivation therapy.

19. What we know about autism's causes

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A White House announcement about autism is expected Monday afternoon after President Donald Trump's weekend comment that "I think we found an answer" to the developmental disorder.

20. Manipulating the body's endocannabinoid receptor may result in neuropsychiatric issues

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Endocannabinoids are similar to the cannabinoids present in cannabis, but they are found naturally in the body. Endocannabinoids—and cannabinoids—work through a signaling system that supports neurodevelopment, but whether manipulating this system prenatally has long-lasting effects remains unclear.

21. How the brain responds to bullying

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In a collaboration at the University of Turku, researchers led by Birgitta Paranko and Lauri Nummenmaa have explored the immediate effects of bullying on the brain.

22. CT scanners secretly waste more energy than used by a typical household, but there's a fix

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Medical imaging is one of the biggest contributors of a hospital's energy use. Magnetic resonance imaging (MRI) and computed tomography (CT) are particularly carbon intensive, partly due to their need to be constantly cooled. Hospital staff typically leave these machines running 24/7 because they're often needed for emergency scans.

23. Mammograms may benefit women well into their 80s, study finds

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For many older women, the question of whether to continue breast cancer screening has been uncertain. While most guidelines recommend mammograms up to age 74, advice for women 75 and older has been less clear. Now, a new study from researchers at the UCLA Health Jonsson Comprehensive Cancer Center suggests that regular mammograms may still offer significant benefits for women in their 80s.

24. Experimental eyedrop formula delivers protective compounds for serious vision problems

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A new eyedrop has shown early success in delivering protective compounds to where they're needed most in the eye, raising hopes for less invasive treatment of serious vision conditions.

25. Diagnostic tool enables rapid leukemia subtype classification

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Researchers at Dana-Farber Cancer Institute have developed a diagnostic tool that could transform the way acute leukemia is identified and treated. The tool, called MARLIN (Methylation- and AI-guided Rapid Leukemia Subtype Inference), uses DNA methylation patterns and machine learning to classify acute leukemia with speed and accuracy. This tool has the potential to significantly improve patient care by allowing faster and more precise treatment decisions.

26. Parathyroid surgery may lower diabetes risk by 30% after correcting hormone imbalance, research reveals

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A new study jointly led by the School of Clinical Medicine at the LKS Faculty of Medicine, of the University of Hong Kong (HKUMed), has found that surgical removal of the diseased parathyroid gland—known as parathyroidectomy—significantly reduces the risk of developing diabetes by 30% in patients with primary hyperparathyroidism (PHPT).

27. Chronic sickle cell pain linked to gut microbial imbalance

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A research collaboration involving scientists and students at The University of Texas at Dallas has found a clear connection between chronic sickle cell disease pain and the bacteria present in the gastrointestinal tract.

28. Arts programs can help prevent heart disease, diabetes and other leading causes of death, large study finds

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Art isn't just for stages and studios. It can be a powerful public health resource. That's the takeaway from a new international study, commissioned by the Jameel Arts and Health Lab, that examined nearly 100 research projects from 27 countries to consider how arts programs, such as music, dance, theater, storytelling and other creative and cultural activities, can help prevent some of the world's biggest killers: heart disease, diabetes, cancer, and other non-communicable diseases, which account for 74% of preventable deaths worldwide.

29. Less invasive brainwave recording uses blood vessels to access activity with unprecedented precision

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Researchers at the University of Osaka have developed a minimally invasive method for recording brain activity through blood vessels. Their article, "Microendovascular Neural Recording from Cortical and Deep Vessels with High Precision and Minimal Invasiveness," is published in Advanced Intelligent Systems.

30. Plain packaging may help tackle teen vaping

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Plain packaging of vape pods reduces young people's interest in trying them, but does not reduce interest among adults, according to a new study led by UCL and King's College London researchers.

31. COVID-19 models suggest universal vaccination may avert over 100,000 hospitalizations

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US Scenario Modeling Hub, a collaborative modeling effort of 17 academic research institutions, reports a universal COVID-19 vaccination recommendation could avert thousands more US hospitalizations and deaths than a high-risk-only strategy.

32. Helping a child with constipation: A pediatrician's advice

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When a child struggles with constipation, it can be a source of frustration and discomfort for the whole family. But a leading pediatric expert offers a clear guide to understanding and treating this common issue.

33. Engineered gut bacteria improve survival outcomes in colorectal cancer tumors

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In a new study that combines synthetic biology with cancer immunotherapy, researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) and Central South University in China have developed an engineered strain of gut-homing bacteria that stimulates potent antitumor immune responses against colorectal cancer (CRC).

34. A surgical team was about to harvest this man's organs—until his doctor intervened

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Lying on top of an operating room table with his chest exposed, Larry Black Jr. was moments away from having his organs harvested when a doctor ran breathlessly into the room.

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