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Ensuring drug safety using AI models for adverse drug reaction prediction

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  • 2025-08-07 00:19 event
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Ensuring drug safety using AI models for adverse drug reaction prediction
Adverse drug reactions (ADRs) are a significant cause of hospital admissions and treatment discontinuation worldwide. Conventional approaches often fail to detect rare or delayed effects of medicinal products. In order to improve early detection, a research team from the Medical University of Sofia developed a deep learning model to predict the likelihood of ADRs based solely on a drug's chemical structure.

519. Red blood cells drive blood clot shrinkage, overturning old assumptions

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Red blood cells, long thought to be passive bystanders in the formation of blood clots, actually play an active role in helping clots contract, according to a new study by researchers at the University of Pennsylvania.

520. COVID-19 mRNA vaccine targeting omicron JN.1 lineage safe

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Vaccination with the updated COVID-19 mRNA vaccine containing the severe acute respiratory syndrome coronavirus-2 omicron JN.1 lineage was not associated with an increased risk for 29 adverse events, according to a study published online July 28 in JAMA Network Open.

521. Study finds significant portion of adult pneumonia hospitalizations linked to preventable pneumococcal infections

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In a recent multicenter prospective study conducted at three hospitals in Tennessee and Georgia, including Vanderbilt University Medical Center, researchers at VUMC found a substantial burden of hospitalizations for community-acquired pneumonia (CAP) among adults.

522. Pregnancy complications associated with higher risk of ischemic stroke before age 50

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Women who experience complications during pregnancy, such as preeclampsia, preterm birth, gestational diabetes, miscarriage, or stillbirth, have an increased risk of ischemic stroke before the age of 50. This is the conclusion of recent research conducted by Radboud university medical center. While the study does not establish a causal relationship, it does highlight a clear association between these pregnancy complications and the risk of early stroke.

523. Intranasal stem cell treatment offers hope for newborns with brain damage

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Oxygen deprivation around birth can lead to brain damage in babies, with far-reaching consequences. A new stem cell treatment administered via nasal drops is showing promising results.

524. Researchers grow human kidney organoids from stem cells, mirroring fetal kidney development over months

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For the first time, researchers from both Sheba Medical Center and Tel Aviv University have grown human kidney organoids (a synthetic 3D organ culture) from tissue stem cells in the laboratory, mirroring human fetal kidney development.

525. Inactivation of key pathway boosts the body's immune response against tumors

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Immunotherapy uses the body's immune system to recognize and destroy cancer cells. One way to do this is through immune checkpoint inhibitors.

526. New studies tie unrecognized deaths and health problems to Maui and LA wildfires

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The toll of wildfires is usually counted in acres burnt, property destroyed and lives lost to smoke and flames. But three studies published Wednesday suggest the cost to human health from the Maui and Los Angeles wildfires was substantially higher.

527. Neuronal imaging system shows sensory activity in real time, study finds

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A new study by UT Health San Antonio and Stanford University scientists brings us closer to understanding how the body detects different sensations such as pain, itch and touch.

528. Ensuring drug safety using AI models for adverse drug reaction prediction

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Adverse drug reactions (ADRs) are a significant cause of hospital admissions and treatment discontinuation worldwide. Conventional approaches often fail to detect rare or delayed effects of medicinal products. In order to improve early detection, a research team from the Medical University of Sofia developed a deep learning model to predict the likelihood of ADRs based solely on a drug's chemical structure.

529. Altered cholesterol uptake by neurons in Alzheimer's disease linked to APOE4 variant

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A study has identified a key disruption in cholesterol transport to the brain in patients with Alzheimer's disease. The findings suggest that the lipoproteins in the cerebrospinal fluid of patients with Alzheimer's have a reduced ability to deliver cholesterol to neurons, and that this impairment may be linked to the presence of the APOE4 genetic variant, one of the main known risk factors for the disease.

530. Clearer conversations, better care: New guide highlights best practices for communicating with older adults

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A new report from the Gerontological Society of America provides critical guidance for health care providers working with the nation's growing older adult population, highlighting strategies to improve communication, build trust, and support better health outcomes.

531. Promising AI-driven surgical education model developed to improve quality of resident training

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Mount Sinai researchers have demonstrated the effectiveness of teaching surgical trainees a difficult procedure using artificial intelligence (AI) algorithms and an extended-reality headset without the presence of an instructor. All of the 17 trainees in the study achieved surgical success.

532. Nonmedical use of prescription ADHD drugs among teens has dropped

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Despite concerns about increased stimulant prescribing, nonmedical use of ADHD drugs among adolescents has declined in the last 20 years, a University of Michigan study shows.

533. Mindfulness techniques help birthing parents manage stress of parenthood

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Becoming a parent is stressful, and it can be especially so for those who already have higher levels of anxiety and worry, but researchers at Penn State have found that the type of birthing class parents take may help them better manage stress.

534. Nearly 12% of Americans have used GLP-1 weight loss drugs

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Nearly 12% of Americans have used GLP-1 drugs for weight loss, including about one-fifth of women aged 50 to 64, according to a new RAND report.

535. An excellent source of protein: Health, hype and hard truths

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Protein is having its moment: From grocery store shelves to Instagram feeds, high-protein foods are everywhere. Food labels shout their protein content in bold, oversized fonts, while social media overflows with recipes promising to pack more protein into your favorite dishes.

536. Older adults are more psychologically resistant to cyberbullying, student-led research finds

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Undergraduate-led research from the University of Warwick has found that older adults are less emotionally affected by negative social media comments.

537. Poll: Americans largely don't support federal changes to child health programs

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Over the last six months, there have been several policy changes affecting children's nutrition benefits, vaccine mandates, and more. A new survey from Emory University's Rollins School of Public Health reveals how American adults view these recent federal actions and proposals.

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