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Fiber-optic method allows real-time monitoring of Alzheimer's plaques in freely behaving mice

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  • 2025-09-30 03:49 event
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Fiber-optic method allows real-time monitoring of Alzheimer's plaques in freely behaving mice
Alzheimer's disease is marked by the buildup of amyloid plaques in the brain, but most ways of studying these deposits in mouse models require sacrificing the animals. That limits researchers' ability to follow how the disease develops or how treatments work over time.

1. Children lose 8.45 million days of healthy life due to second hand smoke, research indicates

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Children lose 8.45 million days of healthy life each year globally due to secondhand smoke, according to research presented at the European Respiratory Society Congress in Amsterdam, the Netherlands. Children from low socioeconomic regions face the biggest impact of breathing secondhand smoke, also known as passive smoking.

2. Indoor wood burners linked to a decline in lung function

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Using a wood-burning stove at home can lead to a decline in lung function, according to research presented at the European Respiratory Society Congress in Amsterdam, the Netherlands.

3. Radiation therapy shows promise for patients with severe heart rhythm disorder

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Radiation therapy may offer a comparable and potentially safer alternative to repeat catheter ablation for patients with severe abnormal heart rhythms that can no longer be controlled with medication.

4. Could nasal sprays replace needles for delivering adrenaline to anaphylactic patients?

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Instead of stabbing yourself, or someone else, in the thigh with a needle to deliver a dose of adrenaline to counter anaphylactic shock, would it not be easier to use a nasal spray instead?

5. Risk for behavioral problems elevated for children with allergic rhinitis

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Children with allergic rhinitis (AR) have an increased risk for behavioral problems (BPs), which are partly mediated by sleep disturbance (SD), according to a study published online Sept. 14 in the Annals of Medicine.

6. FDA approves Opzelura for atopic dermatitis in children

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The U.S. Food and Drug Administration has approved Opzelura cream 1.5% (ruxolitinib) for children ages 2 to 11 years with atopic dermatitis (AD).

7. A2 milk is not always the best option for milk-sensitive individuals, study suggests

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A recent Finnish study investigated the effects of A2 milk, marketed as a gut-friendly alternative, and protein-hydrolyzed lactose-free milk on gastrointestinal symptoms and inflammation levels. The study found that protein-hydrolyzed lactose-free milk was as tolerated as A2 milk by lactose-tolerant individuals and better tolerated by lactose-intolerant individuals.

8. Too heavy for medical care: Over 40% of specialty clinics turn away patients weighing 465 pounds

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Patients weighing 450 pounds or more face barriers and discrimination when scheduling or attending doctor visits at subspecialty practices, reports a new Northwestern Medicine study.

9. AI body composition measurements can predict cardiometabolic risk

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Adiposity—or the accumulation of excess fat in the body—is a known driver of cardiometabolic diseases such as heart disease, stroke, type 2 diabetes, and kidney disease. But getting the full picture of a person's risk is harder than it may seem. Traditional measures such as body mass index (BMI) are imperfect, conflating fat and muscle mass and not capturing where in the body fat is located.

10. Fiber-optic method allows real-time monitoring of Alzheimer's plaques in freely behaving mice

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Alzheimer's disease is marked by the buildup of amyloid plaques in the brain, but most ways of studying these deposits in mouse models require sacrificing the animals. That limits researchers' ability to follow how the disease develops or how treatments work over time.

11. Medicaid unwinding associated with less medication treatment for opioid use disorder

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The end of pandemic-era enrollment enhancements for Medicaid was associated with a rise in the number of people ending medication treatment for opioid use disorder, as well as a decrease in the number of people beginning such treatment, according to a new RAND study.

12. Engineered albumin-fused FIX extends hemophilia B treatment half-life beyond standard 3–4 day window

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After blood vessel damage, effective blood clotting is essential to halt bleeding. However, this process is inefficient in some individuals due to hereditary factors. Hemophilia B, for example, results from a deficiency in coagulation factor IX (FIX), which can lead to prolonged bleeding after injuries or surgery.

13. A novel test could enable early diagnosis of and better treatments for leptospirosis

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In a new study, Yale School of Medicine (YSM) researchers unveiled a novel diagnostic method for detecting leptospiral virulence-modifying (VM) proteins in the blood and urine of hamsters, an advance that could pave the way for early diagnosis of the tropical disease leptospirosis in humans and improved treatment options. The findings appear in the journal Microbiology Spectrum.

14. Shorter radiation improves patient experience but not disease control for intermediate-risk prostate cancer, trial finds

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For patients with intermediate-risk, localized prostate cancer, radiation therapy delivered in five sessions reduced patient-reported side effects compared to longer courses of radiation, according to results of a large, randomized phase III trial. Patients treated with stereotactic body radiation therapy (SBRT) reported fewer declines in bowel, urinary and sexual functioning but were more likely to experience a rise in prostate-specific antigen (PSA).

15. Randomized study comparing proton and photon radiation for breast cancer finds both preserve quality of life

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The first randomized trial to compare photon- and proton-based radiation therapy for breast cancer finds that patients report equally strong health-related quality of life with either treatment. Patients who received proton therapy were more likely to say they would recommend or choose it again, but overall patient-reported outcomes were similar.

16. FDA reviewing safety of abortion pill mifepristone

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The U.S. Food and Drug Administration (FDA) is reviewing the safety of mifepristone, a drug used in medication abortions for 25 years, amid a push from conservative state attorneys general and anti-abortion groups.

17. Enlarged cancer cell nuclei may limit spread rather than signal severity

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In tissue biopsies, cancer cells are frequently observed to have nuclei (the cell's genetic information storage) that are larger than normal. Until now, this was considered a sign that the cancer was worsening, but the exact cause and effect had not been elucidated.

18. RSV vaccine uptake in pregnancy linked to perinatal outcomes and health inequities

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Uptake of the respiratory syncytial virus (RSV) vaccine during pregnancy is not linked to increased risk of adverse perinatal health outcomes among vaccinated women, according to research at City St George's and published in BMJ Open.

19. Frozen meals sold at Walmart, Kroger and Trader Joe's linked to listeria outbreak

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Federal health officials have expanded their probe into a listeria outbreak that has claimed four lives and affected at least 20 people.

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