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Fighting leukemia by breaking a hidden cell loop

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  • 2025-07-14 16:00 event
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Fighting leukemia by breaking a hidden cell loop
Researchers at MUSC Hollings Cancer Center have identified a signaling loop involved in the growth and persistence of leukemia cells—and developed a novel immunotherapy that can disrupt that loop to boost immune function and improve survival. The findings, published in Nature Communications, offer new hope for treating and preventing cancer.

1.992. Higher anticholinergic use linked to faster decline in mobility and strength

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Kaiser Permanente Washington scientists report that higher cumulative anticholinergic exposure predicted a faster decline in gait speed and grip strength among older adults.

1.993. New AI system uncovers hidden cell subtypes, boosts precision medicine

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In order to produce effective targeted therapies for cancer, scientists need to isolate the genetic and phenotypic characteristics of cancer cells, both within and across different tumors, because those differences impact how tumors respond to treatment.

1.994. Lonely adults may have a higher risk of diabetes, study indicates

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Socially isolated older adults are at increased risk of developing diabetes and high blood sugar, according to a study being presented at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, Calif.

1.995. Maternal depression substantially compromises parenting quality

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Mothers experiencing depression have considerable challenges across multiple parenting domains, according to a global systematic review published in the Harvard Review of Psychiatry.

1.996. Multi-component strategies for cholesterol control beyond adherence

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Pharmacy researchers at the National University of Singapore (NUS) have demonstrated that multi-component interventions are required to improve the regular intake of cholesterol-lowering medications.

1.997. New bride survived removal of a 40-pound tumor

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A young woman became a June bride months after surviving complex surgery to remove a 40-pound tumor from her body, Cedars-Sinai doctors report.

1.998. World's premier cancer institute faces crippling cuts and chaos

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The Trump administration's broadsides against scientific research have caused unprecedented upheaval at the National Cancer Institute, the storied federal government research hub that has spearheaded advances against the disease for decades.

1.999. Program launched for patients with obesity concerns who are planning a pregnancy

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Northwestern Medicine has launched a program to help patients who have concerns related to obesity and are planning a pregnancy.

2.000. Clinical trial shows taking blood pressure medication at night improves nocturnal and daytime control

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Research led by Sichuan University in China has revealed that bedtime antihypertensive medication dosing improves nocturnal blood pressure control over morning dosing in patients with hypertension.

2.001. Fighting leukemia by breaking a hidden cell loop

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Researchers at MUSC Hollings Cancer Center have identified a signaling loop involved in the growth and persistence of leukemia cells—and developed a novel immunotherapy that can disrupt that loop to boost immune function and improve survival. The findings, published in Nature Communications, offer new hope for treating and preventing cancer.

2.002. Not all 'forever chemicals' are equal: Experts call for nuanced PFAS policy to protect public health and the environment

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The public, legislators, and media often group per- and polyfluoroalkyl substances, known as PFAS or "forever chemicals," which are found globally in countless products, into a single category. While certain PFAS are harmful for human and public health, new articles in Heart Rhythm emphasize that fluoropolymers, a specific class of PFAS, are not considered environmental contaminants and are indispensable for use in medical devices. Experts call for a balanced approach to protect both the environment and availability of essential medical technologies.

2.003. New study finds sharp increase in nicotine pouch ingestions among young children

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A new study reveals that ingestions of nicotine pouches by young children have surged in recent years. Researchers at the Center for Injury Research and Policy of the Abigail Wexner Research Institute at Nationwide Children's Hospital and the Central Ohio Poison Center analyzed calls to U.S. poison centers and found an alarming 763% increase in the rate of reported nicotine pouch ingestions among children younger than 6 years old from 2020 to 2023.

2.004. Supporting autistic patients in health care

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Caring for autistic patients requires a unique approach, and a new study published in the Canadian Medical Association Journal provides tips on looking after these patients.

2.005. Obesity rates in Canada increased after start of COVID-19 pandemic

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A new study published in theCanadian Medical Association Journal found obesity rates based on body mass index (BMI) increased faster in the four years after the start of the pandemic than in the previous 11 years, especially in younger adults.

2.006. Grandfather's environmental chemical exposures may influence when girls get first period

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A grandfather's exposure to endocrine-disrupting chemicals may impact the age when his granddaughter starts her first period, according to a study being presented Sunday at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, Calif.

2.007. AI-powered application enables clinicians to diagnose endocrine cancers faster and more accurately

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A novel artificial intelligence (AI) application capable of diagnosing endocrine cancers with speed and accuracy is being presented Sunday at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, Calif.

2.008. Early-life exposure to endocrine-disrupting chemicals may fuel food preferences

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Exposure to endocrine-disrupting chemicals in early life, including during gestation and infancy, results in a higher preference for sugary and fatty foods later in life, according to an animal study being presented Sunday at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, Calif.

2.009. Age at woman's first period can offer clues about long-term health risks

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The age at which a woman has her first period can offer valuable clues about her long-term risk for conditions like obesity, diabetes, heart disease and reproductive health issues, according to a study being presented Sunday at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, Calif.

2.010. Intermittent energy restriction may improve outcomes in people with obesity and type 2 diabetes

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Intermittent energy restriction, time-restricted eating and continuous energy restriction can all improve blood sugar levels and body weight in people with obesity and type 2 diabetes, according to a study being presented Sunday at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, Calif.

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