Gene linked to rheumatic disease controls cell movement

Rapidly aging populations and rising cases of lifestyle-related diseases (LRDs), like diabetes and hypertension, are driving significant financial strain on government budgets. While regular health checkups under a standardized government program can be a solution, it is not well understood how these initiatives benefit different socioeconomic sections of society and their economic feasibility.

Tooth decay is the most common health condition worldwide. While it is preventable and treatable, billions of people are living with cavities and the pain that accompanies them. Given the massive scale of the problem, there's a growing movement in dentistry to treat cavities without drilling and filling them.

Extreme instances of stress can cause lasting changes to the brain itself. This could leave some people more vulnerable to addiction, a University of Mississippi study concludes.

QIMR Berghofer has unveiled the next-generation of its world-leading melanoma risk prediction calculator to better help Australians take action against one of the country's most deadly, costly, and common cancers that claims more lives each year than the national road toll.

The cell nucleus goes a long way during an immune response, both literally and figuratively.

For over two decades, finasteride—a popular prescription drug taken by millions of men to treat hair loss—has quietly carried a shadow. Behind its cosmetic promise lay disturbing signs of deeper harm: depression, anxiety, and in some cases, suicide.

The new Nordic dietary guidelines, which consider both our health and the health of the planet, are associated with longer life, according to a new study from Aarhus University.

Parkinson's disease causes both movement and cognitive deficits, and for a long time both were thought to be caused by the accumulation of a protein called alpha-synuclein in the brain. But a new Nature Communications study has found that the cognitive deficits arise through a different—and unexpected—mechanism.

In a clinical practice guideline issued by the American Gastroenterological Association and published in the October issue of Gastroenterology, conditional recommendations are presented for the diagnosis and management of gastroparesis.

A specially developed cannabis extract relieves chronic lower back pain, according to a clinical trial published Wednesday that experts are calling the first high-quality evidence that something in the cannabis plant can treat pain.

New research from Indiana University School of Medicine scientists has revealed that a well-known cancer-fighting gene also plays an unexpected role in regulating how certain immune cells can support tumor growth. This insight into pancreatic cancer progression could lead to more effective treatments against one of the deadliest forms of cancer.

With nearly 5 billion people flying each year, medical emergencies in the air may be more common than most realize and they can be deadly.

A new mRNA vaccine stopped allergens from causing dangerous immune reactions and life-threatening inflammation in mice, according to researchers from the Perelman School of Medicine at the University of Pennsylvania and Cincinnati Children's. The vaccine, outlined in the Journal of Clinical Investigation, may one day be tested and tailored to a variety of seasonal and food allergies.

For patients with recurrent retroperitoneal sarcomas that cannot be treated surgically, treatment choices are limited. These tumors can grow quite large in the abdomen adjacent to vital organs or enmeshed within the bowel. Given their radioresistant nature, they require high doses of radiation that risk damaging healthy nearby tissue. Once patients have undergone an initial radiation course, doctors are often left with no safe radiation treatment option.

Radiation therapy could be an underused tool to reduce pelvic relapse risk for patients with locally advanced, muscle-invasive bladder cancer, according to results of a new Phase III randomized trial.

A new phase III clinical trial finds that intensity-modulated radiation therapy (IMRT) and proton beam therapy resulted in similar quality-of-life outcomes and low rates of side effects for people with locally advanced oropharyngeal cancer. The TORPEdO trial, a randomized study conducted across the United Kingdom, found no meaningful differences between the treatments in patient-reported quality of life, swallowing function or feeding tube dependence at one year.

Until now, weight reduction has been the primary therapeutic goal for people with prediabetes. An analysis of a large Tübingen study shows that patients who bring their blood sugar levels back within the normal range through a healthy lifestyle but do not lose weight, or even gain weight, still reduce their risk of type 2 diabetes by 71%. Researchers from the University Hospital of Tübingen, Helmholtz Munich, and the German Center for Diabetes Research (DZD) were involved in the study published in Nature Medicine.

Dementia is a condition that results in progressive memory or thinking problems. It's now the most common cause of death in Australia. There are many different causes of dementia, but Alzheimer's disease accounts for about 60%–80% of all cases.