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Gut bacterial adhesion mechanism revealed as target for novel colorectal cancer therapies

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  • 2025-09-20 00:39 event
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Gut bacterial adhesion mechanism revealed as target for novel colorectal cancer therapies
Fusobacterium nucleatum (F. nucleatum) is an anaerobic bacterium notably enriched in the gut microbiota of colorectal cancer (CRC) patients and may play a role in CRC both by colonizing tumor cells and suppressing immune mechanisms. Understanding how this bacterium adheres to cancer cells could provide key targets for developing novel antitumor therapies.

1. New initiative targets faster shock diagnosis and care with 'door to lactate clearance'

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A new initiative by The Society for Cardiovascular Angiography & Interventions (SCAI) proposes a new framework and call to action for managing cardiogenic shock (CS), establishing lactate clearance potentially as the standardized, time-based marker of patient trajectory to improve outcomes in one of the deadliest cardiovascular emergencies.

2. New study may help uncover the true impact of childhood lead exposure

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Lead exposure in childhood may be even more dangerous for cognitive development and school performance than previously thought, according to a new analysis led by data scientist Joe Feldman.

3. Metabolism does more than fuel embryonic growth—it also controls the tempo of development, researchers discover

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Pregnant women rely on a balanced diet and supplements to deliver proper nutrients to their babies, to ensure they grow healthfully. Such nutrients contribute to fueling development and providing cellular building blocks that lead to healthy brains, bones, organs, and immune systems.

4. Alpha cells moonlight as secret GLP-1 factories: Hormone shift could transform type 2 diabetes treatment

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A new study from Duke University School of Medicine is challenging long-standing views on blood sugar regulation—and pointing to a surprising new ally in the fight against type 2 diabetes.

5. Simple blood tests identify pregnant women at risk of serious complications from high blood pressure in Sierra Leone

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Two simple blood tests could help to predict which pregnant women with high blood pressure are at risk of serious complications, including seizures, stillbirth and newborn death, a new study conducted in Sierra Leone has found.

6. Self-collection for HPV testing can improve cervical cancer screening rates among Asian American women

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Asian American women given the option to collect their own sample for human papillomavirus (HPV) testing after an educational workshop completed cervical cancer screening at much higher rates compared with workshop attendees who were referred to clinics, according to results presented at the 18th AACR Conference on the Science of Cancer Health Disparities, held September 18–21, 2025.

7. Study shows promising quality of life for those with Down syndrome and congenital heart defects

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Adults with both Down syndrome and congenital heart defects, also known as congenital heart disease (CHD), are showing remarkable resilience despite facing significant medical challenges, according to a new MUSC study published in Pediatric Cardiology. The study found that adults ages 18 to 45 with both conditions are just as likely to work, volunteer and experience the same quality of life as those with Down syndrome alone.

8. Inhaling cannabis may greatly increase your risk of getting asthma

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If you're looking to reduce your chances of developing lung disease, say experts at UC San Francisco, then it may be smart to avoid inhaling cannabis.

9. Consumption of food additives during pregnancy can alter offspring gut microbiota and increase inflammatory disease risk

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A study conducted in mice by scientists from the Institut Pasteur and Inserm reveals that maternal consumption of dietary emulsifiers can have a negative impact on the gut microbiota of their offspring. These microbiota alterations are thought to significantly increase their risk of developing chronic inflammatory gut disorders and obesity in adulthood.

10. Gut bacterial adhesion mechanism revealed as target for novel colorectal cancer therapies

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Fusobacterium nucleatum (F. nucleatum) is an anaerobic bacterium notably enriched in the gut microbiota of colorectal cancer (CRC) patients and may play a role in CRC both by colonizing tumor cells and suppressing immune mechanisms. Understanding how this bacterium adheres to cancer cells could provide key targets for developing novel antitumor therapies.

11. Health researchers discuss Medicaid cancer screening trends, best practices

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New Jersey has the 10th-highest rate of cancer incidence in the United States. It is the second leading cause of death in New Jersey, and thousands of residents die from preventable cancers each year.

12. Dormant no more: Brain protein's hidden role may reshape psychiatric and neurological treatments

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In a new research report, scientists at Johns Hopkins Medicine say they have identified a potential target for drugs that could dial up or down the activity of certain brain proteins in efforts to treat psychiatric disorders, such as anxiety and schizophrenia, and a neurological condition that affects movement.

13. Sugary drinks may increase risk of metastasis in advanced colorectal cancer

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A new study from researchers at The University of Texas MD Anderson Cancer Center shows that the glucose-fructose mix found in sugary drinks directly fuels metastasis in preclinical models of advanced colorectal cancer. The study was published today in Nature Metabolism.

14. Surgical volume increases with introduction of holmium laser enucleation of the prostate

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Introducing holmium laser enucleation of the prostate (HoLEP) for benign prostatic hyperplasia increases surgical volume in urology practices, according to a study published online Aug. 20 in the Journal of Biological Methods.

15. Study finds no extra benefit from well-known children's mental health program

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A new study from The University of Manchester has found that a well-known mental health intervention for children may be no more effective than the usual social and emotional learning (SEL) programs already being taught in primary schools.

16. Young adult cancer survivors may face elevated social risks

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Young adult survivors of cancer aged 18 to 39 faced elevated social risks compared with their peers who did not have cancer histories and survivors from older age cohorts, according to a study presented at the 18th AACR Conference on the Science of Cancer Health Disparities, held September 18–21, 2025.

17. Tuberculosis bacterium disables key immune sensor to evade host defenses, study reveals

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A research team has uncovered a new mechanism that allows Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis (TB), to evade host immune defenses.

18. Cerebellar brain stimulation may boost reward processing in healthy adults

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A study published in The Cerebellum provides initial experimental evidence that a single session of cerebellar High-Definition Transcranial Direct Current Stimulation (HD-tDCS) may help to maintain anticipatory and consummatory pleasure and enhance reward sensitivity in healthy individuals.

19. Loneliness and anxiety fuel smartphone and social media addiction in 'night owls,' new study finds

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Young adult "night owls" (or "evening types"—those who prefer to stay up late) are significantly more at risk of developing problematic relationships with smartphones and social media, according to a new study.

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