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Spinal muscular atrophy (SMA) is a rare genetic condition that causes progressive muscle weakness, which, when untreated, prevents infants with the most severe form from gaining motor development—never gaining the ability to sit—and typically leads to death before 2 years of age.
Immunotherapy employs patients' own immune systems to fight cancer, and it has shown itself to be an effective treatment in many cases. However, some cancers, like triple-negative breast cancer (TNBC), show resistance to immunotherapy. This occurs when tumor cells find ways to evade immune detection—like suppressing immune signaling pathways. One such mechanism is the use of long noncoding RNAs (lncRNAs), which have been found to regulate cancer biology and immune evasion. These lncRNAs render immunotherapies, like the PD-1 inhibitor, pembrolizumab, ineffective.
Determining whether a cancerous tumor originated in a given location or spread there from another tissue or organ in the body is important when assessing the likely course of a patient's disease. When the origin of the primary tumor cannot be identified, it can be challenging to properly diagnose the malignancy and determine the best treatment strategy.
Having a furry friend in your therapy session could lead to your next big breakthrough, according to new research from Swinburne University of Technology.
A diet rich in vegetables and fruit is associated with reduced psychological distress, a detailed analysis of health survey data from more than 45,000 Australians has found.
There have now been 90 confirmed cases of Legionnaires' disease in central Harlem, and 15 people are currently hospitalized battling the disease, the city's health department announced.
The nationwide shortage of sodium chloride 0.9% intravenous (IV) saline has officially ended, according to the U.S. Food and Drug Administration.
AI is detecting tumors more often and earlier in the Dutch breast cancer screening program. Those tumors can then be treated at an earlier stage. This has been demonstrated by researchers led by Radboud university medical center in a study published in The Lancet Digital Health. The use of AI could reduce workload and save millions of euros annually.
Researchers at the Icahn School of Medicine at Mount Sinai have found that prenatal exposure to acetaminophen may increase the risk of neurodevelopmental disorders, including autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD), in children.
In the latest evidence that meaningful social connections bolster health, a team from The University of Texas at Austin and University of Massachusetts Boston has found that regular time spent helping outside the home significantly slows cognitive decline in middle-aged and older adults.
The Massachusetts Department of Public Health raised the risk level for West Nile Virus, or WNV, to high in many communities, urging residents to protect themselves against the mosquito-borne disease.
The measles outbreak in Texas has slowed "dramatically" in recent weeks, but experts still expect the virus to continue to spread.
Advanced technology has boosted the ability of children and adults to manage their type 1 diabetes, a new study says.
For children with adenotonsillar hypertrophy (ATH) and obstructive sleep-disordered breathing (OSDB), adenotonsillectomy is associated with a significant reduction in resting heart rate and estimated cardiac output (COEst), according to a study published online in Clinical Otolaryngology.
Adolescents who undergo bariatric surgery face a higher risk of weight regain, which can undermine treatment success and long-term health, if they have elevated blood levels of per- and polyfluoroalkyl substances (PFAS) prior to the procedure, according to new USC research.
Drug treatment for people with newly diagnosed attention deficit hyperactivity disorder (ADHD) is associated with significantly reduced risks of suicidal behaviors, substance misuse, transport accidents, and criminality, finds a study published by The BMJ.
As the nation gears up for the rollout of an updated COVID-19 vaccine, a new study shows the economic benefits of continued broad vaccination in adults.
A study in JDR Clinical & Translational Research demonstrates that arginine dentifrices reduce dental caries in children with active caries as effectively as or more effectively than a sodium fluoride dentifrice, depending on the arginine concentration.
A study from Denmark shows for the first time that men with biochemically recurrent prostate cancer who undergo PSMA PET/CT before salvage radiotherapy have improved survival rates compared to those who do not.