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How the interaction of two 'epigenetic guardians' protects neuronal identity

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  • 2025-09-10 20:03 event
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How the interaction of two 'epigenetic guardians' protects neuronal identity
Neurons are highly specialized cells, and their proper functioning depends on preserving their identity throughout life. A team of researchers has identified that two enzymes, KDM1A and KDM5C, interact to act as true "epigenetic guardians." Their role is to silence genes that do not belong to neurons and to keep only the appropriate instructions active.

629. Child health report ignores gun violence, the leading cause of child death

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The Make America Healthy Again Commission, led by Robert F. Kennedy Jr., has released its Make Our Children Healthy Again Strategy, a 20-page report the U.S. Department of Health and Human Services described as a "sweeping plan" to "reverse the failed policies that fueled America's childhood chronic disease epidemic."

630. Prevalence of diaper insecurity found to be 41% in urban health centers

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In a cross-sectional study conducted in nine urban Federally Qualified Health Centers and published online in Pediatrics, the prevalence of diaper insecurity was 41% among pediatric patients aged 0 to 36 months.

631. Beyond breasts and babies: Expert says women's health held back by medical blind spots

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A UNSW Sydney researcher says narrowing women's health to "bikini medicine"—issues that occur between the breasts and the pubic bone—has left women underserved in nearly every other area of health, including disease, aging and chronic illness.

632. Foreign aid crunch threatens malaria fight: Global Fund

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Malaria deaths are likely to rise this year due to sweeping foreign aid cuts, the head of the Global Fund, a Geneva-based NGO locked in the fight against major infectious diseases, warned on Wednesday.

633. Who updates list of essential medicines to include GLP-1s

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The World Health Organization published updated editions of its Model List of Essential Medicines (EML) and Essential Medicines for Children (EMLc) to include new treatments for several cancers as well as for diabetes and related conditions such as obesity.

634. Giant DNA discovered in people's mouths could impact oral health, immunity and even cancer risk

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Researchers, including those at the University of Tokyo, have made a surprising discovery hiding in people's mouths: Inocles, giant DNA elements that had previously escaped detection. These appear to play a central role in helping bacteria adapt to the constantly changing environment of the mouth.

635. New research uncovers link between perfectionism and pain

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A little self-compassion can go a long way when you have chronic pain, according to a new study out of Murdoch University. The research found that psychological factors may play a crucial role in the experience and management of chronic pain.

636. Yoga isn't just for flexibility—it may also protect brain health

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Anyone who has taken a yoga class knows how relaxing it can be to set aside the day's worries and focus on breathing, gentle movements, healing stretches and guided meditation, even if just for an hour.

637. Seizure spread across the brain marks loss of consciousness

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Loss of consciousness can pose real dangers for people with seizure disorders. And while not all seizures cause loss of consciousness, Yale researchers have now discovered how one common type of seizure does.

638. How the interaction of two 'epigenetic guardians' protects neuronal identity

  • 1 week ago schedule
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Neurons are highly specialized cells, and their proper functioning depends on preserving their identity throughout life. A team of researchers has identified that two enzymes, KDM1A and KDM5C, interact to act as true "epigenetic guardians." Their role is to silence genes that do not belong to neurons and to keep only the appropriate instructions active.

639. What motivates runners? Focusing on the 'how' rather than the 'why'

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As attention turns to this year's New York City Marathon, observers will again ask a long-standing question: What do athletes draw upon when trying to complete this 26.2-mile run, especially at those stretches when finishing seems impossible?

640. A simplified way to identify harmful medications in older adults with cancer

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New research validates the use of a specifically-curated tool for determining which medications may be causing harm for older patients with cancer.

641. Universal school meals prove a win for kids, families and the planet

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A recent article in the Journal of Epidemiology and Community Health evaluates school meal programs in four major global cities and how they work to advance children's health.

642. Study finds that push to prescribe fewer antibiotics is working

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Efforts to reduce unnecessary antibiotic use are working, according to researchers from The University of Western Australia who have identified a decade-long decline in the number of antibiotics dispensed to Australian children.

643. New insights into the gut–brain axis decode chronic pain pathways

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An Adelaide-based research collaboration has identified the specific nerve pathways responsible for relaying pain signals from the bowel to the brain, paving the way for new irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) treatments.

644. Misconceptions keep some cancer patient populations from benefiting from hormone therapy, survey reveals

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Despite evidence suggesting the safety of hormone therapy for patients with a history of low-grade endometrial or epithelial ovarian cancer, a new survey shows that many gynecologists and some gynecologic oncologists are still uncomfortable prescribing the therapy for this patient population. This indicates a need for more clinician education to help overcome lingering misconceptions.

645. Breaking the code of sperm motion: Two proteins found vital for male fertility

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There are many potential causes of infertility, and it can be challenging to pin down just what the problem is when a couple is having trouble getting pregnant. Now, researchers show that a few key proteins have a major effect on sperm development, and therefore male fertility.

646. Children lose muscle during early cancer treatment: Study warns of a hidden danger to recovery

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New research from the Exercise Medicine Research Institute at Edith Cowan University (ECU) has highlighted that children undergoing cancer treatment often lose skeletal muscle at a time when they should be rapidly gaining it, a loss that could increase treatment complications and raise the risk of long-term health problems.

647. Obese surpass undernourished youths for first time, UN warns

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Obesity has skyrocketed among children and adolescents bombarded by "unethical" marketing of junk food, outpacing undernourishment to become the leading form of malnutrition worldwide for the first time among those age five to 19, UNICEF warned Tuesday.

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