Huntingtin protein arranges cytoskeletal filaments, offering insight into neurodegeneration

Certain nutrients in food can trigger a mild stress response in nematodes. But instead of making them sick, this actually helps them stay healthier as they age, according to researchers at the University of Basel, Switzerland.

Researchers at the University of Bath, in collaboration with the Universities of Oxford and Bristol, have developed a molecule that prevents the clumping and build-up of a protein linked to Parkinson's disease and related dementias. The team has successfully demonstrated it works in an animal model of Parkinson's and hopes that in the future this could lead to a treatment that slows the progression of the disease.

A new brain imaging study led by researchers in the Department of Psychiatry and Behavioral Health in the Renaissance School of Medicine (RSOM) at Stony Brook University, and published in JAMA Network Open, uses a specialized type of magnetic resonance imaging (MRI) technique named neuromelanin-sensitive MRI to shed light on the link between chronic depression and the neurotransmitter dopamine. Dopamine plays important roles in many cognitive, emotional, and bodily functions and is a central cellular component to the reward/motivation system of the brain.

A new study led by University of California, Irvine's Center for the Neurobiology of Learning and Memory researchers found that aging changes the brain's overall shape in measurable ways. Instead of focusing only on the size of specific regions, the team used a new analytic method to see how the brain's form shifts and distorts over time.

A new international QUT-led study found that bariatric surgery improves work productivity and employment rates in the short term—but these gains may not last beyond five years without targeted support.

The Herpes simplex virus is a widespread virus that often causes cold sores, and most people carry it. By removing a virulence gene, i.e. a gene that makes the virus harmful to humans, the herpes virus can be repurposed as a cancer vaccine. This modification prevents the virus from harming healthy tissue while allowing it to target cancer cells, which function differently from normal cells. These findings are presented in a new doctoral thesis at Åbo Akademi University, Finland.

Previously, the primary endpoint results of the NRG-LU005 study assessing the addition of the immunotherapy drug atezolizumab to standard of care concurrent chemoradiation for limited-state small cell lung cancer were reported at the American Society for Radiation Oncology 2024 Annual Meeting.

Previously, results from the photon cohort of the NRG-BN001, a signal seeking Phase II randomized trial, indicated that photon radiation dose intensification (75 Gy) did not demonstrate improvement in overall survival (OS) for patients with newly diagnosed glioblastoma (GBM).

Demand-responsive transport (DRT) is promoted as an inclusive solution to first- and last-mile mobility challenges, but little is known about the barriers to adoption among people with poor health.

A concerted effort to improve the workplace culture at a California hospital produced a variety of significant improvements, with an impact far beyond the initial goals, according to an article in Critical Care Nurse.

Research conducted at West Virginia University suggests consuming alcohol with fentanyl and other drugs may explain, in part, why more men than women die from unintentional overdoses.

"Ear seeding" is having a moment on TikTok and Instagram. One video of someone's experience of ear seeding has been "liked" more than half a million times. Supermodel Naomi Campbell is among celebrities reported to have tried it.

If there are prediction models for who might be at risk of cancer or diabetes so that they can get attention before it's too late, why can't there be a predictor for overdoses? A new tool designed to help people who use stimulants like cocaine or methamphetamine answers that question, using demographics and other available information to identify who is at risk.

What impact do screens have on teenagers' sleep? A study by the University of Geneva (UNIGE), conducted in secondary schools in collaboration with the Department of Public Education, Training and Youth (DIP) of the Republic and Canton of Geneva, shows that strict parental rules on smartphone use in the evening are associated with a significant increase in sleep duration and better academic performance. These findings have now been published in Discover Public Health.

A new study from researchers at The University of Texas at Austin reveals that following a low-calorie or low-carbohydrate diet can measurably lower levels of brain chemicals that, when too high, are linked to inflammation and memory problems.

A new Commonwealth Fund report offers the first state-by-state ranking of how vulnerable individual health and health care systems are to climate risks.

Children in care who experience frequent changes in care placements are more than twice as likely to experience mental health problems, according to new research led by the University of Bath in the UK.

Around half a million stents are implanted in Germany every year to treat narrowing of the blood vessels, a consequence of atherosclerosis. However, conventional models made of metal or polymers injure the endothelium, the protective innermost cell layer of the blood vessels, when they are inserted. This cell layer takes a long time to regenerate, and if it is damaged, there is also an elevated risk of thrombosis. To prevent blood clotting and thus thrombosis at the stent site, patients must take high doses of anticoagulant medications—often for the rest of their lives.