Improving prediction of worsening knee osteoarthritis with an AI-assisted model

As we age, our cells replicate, and the DNA in these cells can acquire mistakes—or mutations—every time the sequence is copied. Most newly acquired mutations are harmless, but some can tip the balance toward cancer development later in life.

Prioritizing communications between patients and health care providers and increasing patient education about chronic obstructive pulmonary disease (COPD) could help improve patient care, according to a new study published in the July 2025 issue of Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation.

Research out of the University of New Hampshire shows that communities that were easier for people to lace up and get out for a walk during the COVID-19 pandemic also helped lower the impact of mental health issues, like stress and anxiety.

Brucellosis is a serious and often neglected disease endemic to many low- and middle-income countries around the world. Because it shares many of the same clinical symptoms as malaria—including fever and joint pain—it can be misdiagnosed.

Scientists at St. Jude Children's Research Hospital demonstrated for the first time that the protein midkine plays a preventative role against Alzheimer's disease. Midkine is known to accumulate in Alzheimer's disease patients. Now, researchers have connected it with amyloid beta, a protein that accumulates in the brain, causing assemblies that are a hallmark of Alzheimer's.

The COVID-19 virus hijacks the machinery of testicular cells that produce the hormone testosterone in order to replicate. It also appropriates the metabolic pathways of these cells and cholesterol, a precursor of testosterone, thereby altering lipid metabolism for its formation.

More than 30 million Americans rely on implanted medical devices like prosthetic joints, pacemakers and more to improve their quality of life. But implanting any foreign object into the body also carries the risk of introducing deadly fungal infections.

Breast cancer patients who participated in a remote weight loss intervention program lost an average of 4.7% of their baseline body weight after one year, while those in the education only control group gained an average 1% of their baseline weight, according to a new report from Dana-Farber Cancer Institute investigators. The findings from the Breast Cancer Weight Loss (BWEL) clinical trial set the stage for ongoing research to determine if weight loss following breast cancer treatment can reduce the risk of cancer recurrence and extend survival.

A team of researchers at the University of Cologne's Center for Biochemistry, together with the Bambino Gesù Pediatric Hospital in Rome, Italy, have discovered a fundamental biological mechanism that directly connects the immune sensor protein STING to inflammatory cell death.

The global incidence of autoimmune diseases among children has increased over the past few decades. A study published in the open-access journal PLOS Medicine by Ju-Young Shin at Sungkyunkwan University, Republic of Korea, and colleagues suggests that early life antibiotic exposure is not associated with an increased risk of autoimmune diseases in children.

Metabolic syndrome (MetS) is associated with an increased risk for Parkinson's disease (PD), according to a study published online Aug. 20 in Neurology.

The U.S. Food and Drug Administration has approved Papzimeos (zopapogene imadenovec-drba) for the treatment of adults with recurrent respiratory papillomatosis (RRP).

Health experts across the country are issuing warnings about a surge in infections from a "flesh-eating" bacterium known as Vibrio vulnificus.

Women with cirrhosis and ascites experience worse health-related quality of life (HRQoL) than men, although no difference is seen in daily function, according to a study published in the August issue of the American Journal of Gastroenterology.

A preclinical evaluation of a new "dual-mode" tracer agent shows promise in not only helping surgeons image and plan prostate cancer procedures, but also provide them with much more consistent and targeted guidance during surgery.

Researchers at the Leibniz Institute for Plasma Science and Technology (INP) have collaborated with partners at Greifswald University Hospital and University Medical Center Rostock to demonstrate that cold plasma can effectively combat tumor cells even in deeper tissue layers.

In adults with autoimmune pulmonary alveolar proteinosis (aPAP), once-daily inhaled molgramostim, a recombinant human granulocyte-macrophage colony-stimulating factor, leads to a greater increase in pulmonary gas transfer than placebo, according to a study published in the Aug. 21/28 issue of the New England Journal of Medicine.

A new study finds a dramatic increase in safe drinking water when a machine learning-enabled tool created by York University researchers is used to optimize chlorination levels in refugee camp water supplies. Lead author Syed Imran Ali says that the new study shows that the Safe Water Optimization Tool (SWOT) vastly outperforms status-quo guidelines for safe water supply in humanitarian response.