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Immune checkpoint blockade medications have revolutionized cancer treatment, giving patients and providers new hope to control and sometimes cure metastatic cancer. However, predicting which patients will benefit from this expensive and sometimes toxic, but potentially lifesaving, class of medications has been a challenge.
In a new observational study, researchers at Lund University in Sweden looked at all children listed for heart transplants in the Nordic countries between 1986 and 2023. A total of 597 children were included in the study, 461 of whom received a transplant. The results show that survival rates have increased significantly over time despite the modest volumes in the region—a development that the researchers attribute to technological advances, advanced technologies and better health care practices.
Flies too need their sleep. In order to be able to react to dangers, however, they must not completely phase out the environment. Researchers at Charité–Universitätsmedizin Berlin have now deciphered how the animal's brain produces this state. As they describe in the journal Nature, the fly brain filters out visual information rhythmically during sleep—so that strong visual stimuli can still wake the animal.
It's been a long-accepted reality that with age comes increased inflammation—so widely accepted it's been dubbed "inflammaging." With this increase in age-related chronic inflammation also comes serious health concerns, such as cardiovascular disease and Alzheimer's. But according to new research, inflammaging isn't as universal of an experience as previously thought.
Large cell neuroendocrine carcinoma (LCNEC), a rare and aggressive type of lung cancer, has a high chance of metastasis, no standard treatment and a poor survival rate. A study published in Nature Communications provides a new understanding of the disease and uncovers a potential target for treatment.
Having a larger waistline, high blood pressure and other risk factors that make up metabolic syndrome is associated with an increased risk of Parkinson's disease, according to a study published in Neurology. The study does not prove that metabolic syndrome causes Parkinson's disease; it only shows an association.
Researchers have found that mitochondrial dysfunction in the blood-brain barrier (BBB) may lead to neuropsychiatric disease in some patients with DiGeorge syndrome.
A collaboration among Rice University, Baylor College of Medicine and Texas Children's Hospital's Jan and Dan Duncan Neurological Research Institute (NRI) has produced a breakthrough in how to study and classify complex diseases.
A study recently published in the European Journal of Preventive Cardiology shows that cardiovascular health is affected not only by the total amount of physical activity, but also by how often you move during the day. Among the oldest participants, the study found that several short walks per day had a protective effect, regardless of pace. This correlation remained even when adjusted for total walking time.
How many times have you stared at a home COVID-19 test, waiting for the faint line that confirms an infection? Those home antigen tests often fail to detect a recent infection or one with no symptoms. A PCR test is more accurate, but it must be done by a medical lab and the results take days to deliver.
It is well established that stress can increase susceptibility to various neuropsychiatric disorders, such as depression and anxiety, which are highly prevalent worldwide and represent a significant economic burden and public health issue in our society. The World Health Organization estimated that in 2019, around 970 million people globally—1 in 8—suffered from a mental disorder.
National Football League (NFL) athletes who play wide receiver or tight end may have a higher risk of suffering an injury to their anterior cruciate ligament, or ACL, according to a new study from the University of Missouri School of Medicine. The research is published in The Journal of Knee Surgery.
A recent University of Michigan-led study finds that 10% of patients hospitalized with sepsis were previously healthy—and many of those who ultimately died did so because it was too late to intervene.
Researchers at Texas Biomedical Research Institute have developed a new, proof-of-concept vaccine to protect people from the bird flu strain currently circulating in the United States. The team, led by Professor Luis Martinez-Sobrido, Ph.D. and Staff Scientist Ahmed M. Elsayed, Ph.D., recently published initial results in npj Vaccines.
A research team led by Bristol and Cambridge universities has demonstrated that the polymer material used to make a new artificial heart valve is safe following a six-month test in sheep.
From "try yoga" to "start journaling," most mental health advice piles on extra tasks. Rarely does it tell you to stop doing something harmful.
It's a fact of life: Some people age better than others. Some ease into their 90s with mind and body intact, while others battle diabetes, Alzheimer's or mobility issues decades earlier. Some can withstand a bad fall or bout of the flu with ease, while others never leave the hospital again.
A new Zika virus vaccine developed in Brazil by researchers at the Institute of Tropical Medicine of the University of São Paulo's Medical School (IMT-FM-USP) has been shown to be safe and effective in tests with mice.
By revealing the molecular mechanisms behind the peacekeeping abilities of specialized immune cells, scientists are uncovering new pathways for treating autoimmune conditions and detecting diseases like cancer.