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Microscopy reveals how Hippo pathway proteins control gene activity in cancer

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  • 2025-07-26 16:43 event
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Microscopy reveals how Hippo pathway proteins control gene activity in cancer
Melbourne scientists are teasing out how the "Hippo pathway" works at the molecular level, improving understanding of how it exerts control and its potential as a much-needed treatment for the deadly cancer mesothelioma.

1.197. Malnutrition rates reach alarming levels in Gaza, WHO warns

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Jerusalem, Cairo, Geneva, 27 July 2025 Malnutrition is on a dangerous trajectory in the Gaza Strip, marked by a spike in deaths in July. Of 74 malnutrition-related deaths in 2025, 63 occurred in July including 24 children under five, a child over five, and 38 adults. Most of these people were declared dead on arrival at health facilities or died shortly after, their bodies showing clear signs of severe wasting. The crisis remains entirely preventable. Deliberate blocking and delay of large-scale food, health, and humanitarian aid has cost many lives. Nearly one in five children under five in Gaza City is now acutely malnourished, as reported by Nutrition Cluster partners. Global Acute Malnutrition (GAM), which measures the percentage of children aged 6–59 months suffering from acute malnutrition, has tripled since June, making it the worst-hit area in the Gaza Strip. In Khan Younis and the Middle Area, rates have doubled in less than one month. These figures are likely an underestimation due to the severe access and security constraints preventing many families from reaching health facilities. So far in July, over 5000 children under five have already been admitted for outpatient treatment of malnutrition in just the first two weeks, 18% of them with Severe Acute Malnutrition (SAM), the most life-threatening form. This continues a significant rising trend since May, with 6500 children admitted for treatment in June, which is Read more...

1.198. Researcher harnesses AI to transform skin cancer diagnosis in remote areas

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A researcher at Heriot-Watt University is harnessing the power of artificial intelligence to give patients living in remote parts access to timely and potentially lifesaving medical diagnoses.

1.199. Continuous glucose monitors are in vogue. But do you really need to track your blood sugar?

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A quarter-size device that tracks the rise and fall of sugar in your blood is the latest source of hope—and hype—in the growing buzz around wearable health technology.

1.200. Obesity prevalence would shift significantly under proposed new criteria, study finds

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In the first multinational study of a proposed change to how obesity is defined—which calls for health factors beyond a person's height and weight to be considered—an international team of researchers found the prevalence of obesity would drop significantly, highlighting concerns that the new criteria could hinder the prevention and early detection of serious health conditions.

1.201. Texts about healthier eating may help prevent childhood obesity

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According to recent estimates by the Centers for Disease Control and Prevention, nearly one in five children in the United States is affected by obesity. Research has shown obesity often begins in infancy, emphasizing the need for early intervention strategies to prevent long-term health consequences such as cardiovascular disease.

1.202. Brain peptide ODN reduces hunger and boosts glucose regulation in rat study

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University of Pennsylvania and Syracuse University scientists have discovered that a hindbrain-derived peptide, octadecaneuropeptide (ODN), can suppress appetite and improve glucose regulation without causing nausea or vomiting. Results suggest a glia-to-neuron signaling axis in the dorsal vagal complex that may be harnessed for treating obesity and type 2 diabetes.

1.203. 'Weekend warrior' workouts reduce diabetics' risk of death, study indicates

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A "weekend warrior" exercise schedule can lower diabetics' risk of early death, a new study says.

1.204. First of its kind study explores symptom prevalence across the menopause transition

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Almost 40 percent of perimenopausal women in a Monash University-led study had untreated and potentially debilitating vasomotor symptoms (VMS) such as hot flushes, night sweats.

1.205. New method estimates measles vaccination rates without up-to-date survey data

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Knowing how many people are vaccinated against an existing or re-emerging threat is a key factor guiding public health decisions, but such information is often sparse or non-existent in many regions, according to researchers at Penn State. Now, in collaboration with a team at the World Health Organization, the researchers have developed a new method to estimate and predict regional measles vaccination coverage levels even when accurate or timely survey data on vaccination is not available. The method uses data that is routinely collected when potential measles cases present at clinics to model vaccination coverage and can be used to guide public health interventions to slow or prevent measles outbreaks.

1.206. Microscopy reveals how Hippo pathway proteins control gene activity in cancer

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Melbourne scientists are teasing out how the "Hippo pathway" works at the molecular level, improving understanding of how it exerts control and its potential as a much-needed treatment for the deadly cancer mesothelioma.

1.207. Injured once, triggered forever? How the brain rewrites stress responses

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A wound can leave a lasting imprint—even after it has healed. A new study in Current Biology finds that past injuries can quietly prime the body to overreact and be more sensitive to stress, pain and fear long after the damage is gone.

1.208. Suboptimal dialysis initiation common in patients with advanced CKD

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Suboptimal dialysis initiation, typically defined as dialysis initiation during a hospitalization and/or with a central venous catheter, is common among patients with advanced chronic kidney disease (CKD) followed in multidisciplinary clinics, according to a study published online July 21 in Kidney360.

1.209. Ritz update: FDA issues risk warning due to undeclared peanuts in some cracker sandwiches

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Ritz peanut butter cracker sandwiches are being recalled due to the possible presence of undeclared peanuts, a major allergen.

1.210. Keurig K-Cups recalled due to potential ink contamination

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Keurig K-Cups are being recalled nationwide due to a packaging issue that could cause ink to run into the coffee during brewing.

1.211. Kinshasa slum battles deadly cholera outbreak

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Faced with a lack of running water, unsanitary conditions and poverty, the Kinshasa neighborhood of Pakadjuma has struggled to end a cholera epidemic that has claimed hundreds of lives in the Democratic Republic of Congo (DRC) this year.

1.212. Southern China hit by outbreak of mosquito-borne infection chikungunya

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China is experiencing an outbreak of chikungunya, a mosquito-borne infection, with thousands of cases reported in the south.

1.213. Chromatin organization linked to p53 tumor suppression mechanism

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Each cell in our bodies carries about two meters of DNA in its nucleus, packed into a tiny volume of just a few hundred cubic micrometers—about a millionth of a milliliter. The cell manages this by winding the strings of DNA around protein spools. The protein-DNA complexes are called nucleosomes, and they ensure that DNA is safely stored.

1.214. Study finds roots of mental and neurodegenerative disorders in fetal brain cells

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The origin of some neuropsychiatric diseases, such as autism, bipolar disorder, or depression, and certain neurodegenerative diseases, Alzheimer's and Parkinson's, can be found in very early stages of brain formation in the fetus. That is, earlier than previously recognized, according to a study by the Hospital del Mar Research Institute and Yale University, published in Nature Communications.

1.215. Laminin-411 peptide shows promise for central nervous system myelin repair

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The laminin-411 protein is vital for the formation of the myelin membrane by oligodendrocytes, report researchers from Japan. Furthermore, the A4G47 peptide from the E8 region of laminin-411 was found to be the main active amino acid sequence that drives myelin formation. The research findings have the potential to transform current cell culture practices to study myelination and may enable the development of novel therapeutic agents to treat demyelinating diseases.

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