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Molecular 'brake' in brain development could hold key to treating multiple sclerosis

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  • 2025-08-25 22:00 event
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Molecular 'brake' in brain development could hold key to treating multiple sclerosis
A team of scientists led by the Institute for Glial Sciences (IGS) at Case Western Reserve University's School of Medicine has discovered a built-in "brake" that controls when key brain cells mature. In multiple sclerosis (MS), this brake appears to stay on too long, leaving the cells unable to repair the damage the disease causes.

1.665. Light pills could transform understanding of how the gut controls the body

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Scientists have long struggled with how to study the gut's vast nervous system—often called the body's "second brain"—without damaging it. Current research methods are invasive and often require complex surgeries that make it difficult to study normal gut function.

1.666. Kennedy's anti-vaccine strategy risks forcing shots off market, manufacturers warn

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Dining under palm trees on a patio at Mar-a-Lago in December, President-elect Donald Trump reassured chief executives at pharmaceutical giants Eli Lilly and Pfizer that anti-vaccine activist Robert F. Kennedy Jr. wouldn't be a radical choice to head the Department of Health and Human Services.

1.667. Assessing severe surgical complications from cesarean deliveries

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Cesarean delivery is the most common inpatient surgery in the U.S. but it also carries inherent surgical risks, including vascular, visceral, soft tissue, and nerve damage, which can lead to significant maternal health complications and even death.

1.668. Is your diet influencing your dreams? Here's what our research says about food and nightmares

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Have you ever wondered if a bizarre dream was caused by something you ate the night before? If so, you're not alone. We all have strange or unsettling dreams now and then, and when we do, we want to know what might cause them.

1.669. Long COVID is more than fatigue—our new study suggests its impact is similar to a stroke or Parkinson's

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When most people think of COVID now, they picture a short illness like a cold—a few days of fever, sore throat or cough before getting better.

1.670. NJ Transit rider tests positive for measles, exposure warning issued

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Health officials in New Jersey are urging locals to stay up to date with the MMR vaccine and be on alert for symptoms after a NJ Transit rider tested positive for measles.

1.671. Researchers identify key metric in delivering focused ultrasound to treat patients with high-grade gliomas

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Researchers found that acoustic emission dose—an acoustic signal from microbubbles—could predict how to adjust ultrasound power and open the blood-brain barrier for delivering drugs in patients with glioblastoma.

1.672. Most epilepsy patients wait a year after starting treatment for seizure relief, study shows

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Antiseizure medications help the majority of people with focal epilepsy, a common form of the neurological disorder. Yet most will still have episodes for at least a year after their treatment begins, until their doctors can find the right drug and dosage for them, a new study shows.

1.673. Study finds higher risk of malignant brain tumors after history of head injuries

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New research led by investigators at Mass General Brigham suggests a link between a history of traumatic brain injury (TBI) and the risk of developing a malignant brain tumor. By evaluating data from 2000–2024 of more than 75,000 people with a history of mild, moderate or severe TBI, the team found the risk of developing a malignant brain tumor was significantly higher compared to people without a history of TBI.

1.674. Molecular 'brake' in brain development could hold key to treating multiple sclerosis

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A team of scientists led by the Institute for Glial Sciences (IGS) at Case Western Reserve University's School of Medicine has discovered a built-in "brake" that controls when key brain cells mature. In multiple sclerosis (MS), this brake appears to stay on too long, leaving the cells unable to repair the damage the disease causes.

1.675. Firearm suicides increasing among older women at an alarming rate, study finds

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Older men are 13 times more likely to die by firearm suicide than women, but a new study by Boston University School of Public Health and the University of California, Los Angeles Luskin School of Public Affairs has found that suicides by gun are increasing rapidly among older women.

1.676. New recommendations on core datasets to be used in systemic lupus erythematosus care

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Systemic lupus erythematosus (SLE) is a complex and potentially life-threatening autoimmune disease. Part of the complexity stems from how it can differ from person to person—giving rise to marked heterogeneity in not only manifestations, but also in disease course and treatment response.

1.677. Clinical trial reveals unprecedented insights into brain cancer treatment

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Victorian brain cancer researchers have achieved a global-first, using an innovative process to learn how a new drug suppresses tumor activity and provides hope to patients with low-grade gliomas (LGG).

1.678. Like likes like: Partner preferences may be explained by genetics

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It is no secret that people are often drawn to romantic partners who seem similar to themselves. This tendency, called assortative mating, has been established in humans as well as other species. Fish, for example, demonstrate the behavior frequently.

1.679. Q&A: Altered lipid metabolism as a possible culprit in age-related vision loss

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When we think of the age-old adage about getting old, "What new ache or pain will each new day bring?" we often imagine ailments such as joint or bone pain, a hyperactive bladder, or even memory loss, but Kevin Schey, Stevenson Professor of Biochemistry at the School of Medicine Basic Sciences, thinks a lot about the loss of eyesight.

1.680. Rare bone disorder traced to deficiency of an 'enzyme-rescue metabolite' in new study

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Living cells contain a world of complex parts, which are constantly in motion. Many functions of these parts are still not fully understood, but likely harbor answers to many of our questions about how diseases work and how we might reverse them. One such case has been brought to light.

1.681. Can immune cells stave off devastating neurodegenerative diseases? Scientists aim to find out

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An evolving form of therapy to treat devastating neurodegenerative disorders by injecting fresh immune cells—microglia—directly into the brain, promises a new lease on health by slowing the progression of mind-robbing conditions.

1.682. Exercise intensity could be impacting your gut

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While exercise is great for both your mental and physical health, new research from Edith Cowan University (ECU) has found that exercise intensity could result in changes to the internal gut biome.

1.683. Why does my child's stomach hurt? 5 common causes of stomach pain in kids

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"My stomach hurts." It's one of the most common complaints from school-aged children and young teens. Occasional stomach pain in kids is normal, but when it happens often, it's important to know the most common causes—and when to call your pediatrician.

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