Molecular-level discovery points to heart protein AIMP3 as potential target for new cardiac treatments

A new study has revealed compelling evidence that brain criticality—a dynamic balance between neural excitation and inhibition—has a strong genetic foundation and is associated with cognitive performance. The research was published on June 23 in the Proceedings of the National Academy of Sciences.

For patients with recessive dystrophic epidermolysis bullosa (RDEB), a one-time surgical application of prademagene zamikeracel, an autologous COL7A1 gene-modified cellular sheet that is sutured onto a large, chronic RDEB wound, improves wound healing and pain versus standard of care, according to a study published online June 23 in The Lancet.

"Latinx" is a gender-neutral term used instead of "Latino" and "Latina" that refers to individuals of Latin American descent. Latinx and sexual minority youth (SMY) report higher rates of alcohol use than white and heterosexual youth. New research finds that Latinx SMY experience and cope with discrimination in unique ways, which can have an impact on their alcohol treatment response. These findings will be shared at the 48th annual scientific meeting of the Research Society on Alcohol (RSA) in New Orleans, Louisiana.

It has long been known that loneliness is a risk factor in the development of anxiety and depression. However, the association itself has been less well studied. This is especially true during the transition from adolescence to adulthood.

For the first time, researchers have found that lung cancer patients who have a combination of high levels of depression and inflammation at diagnosis are later found with continuing depressive symptoms in the next several months, even as they receive new, promising therapies.

Acute myeloid leukemia (AML) is an aggressive cancer affecting the blood and bone marrow that progresses rapidly, making immediate treatment essential. While chemotherapy and targeted drugs have improved outcomes for some patients, many forms of AML remain resistant to treatment, and relapses are common.

Researchers at Forschungszentrum Jülich in Germany have published two new studies offering fresh insight into a protein believed to play a pivotal role in the development of chronic mental health conditions such as schizophrenia.

Most first-time parents in Denmark feel competent and experience low levels of parental stress during their child's first year of life. However, new research shows that some groups find it significantly more difficult—and that parents' support needs change over time.

Researchers have developed a gene therapy that significantly slowed motor function loss in preclinical models of amyotrophic lateral sclerosis (ALS), offering new hope for treating the devastating neurodegenerative disease.

Whether you had breakfast this morning or not, your pancreas is working quietly behind the scenes. This vital organ produces the enzymes that help digest your food and the hormones that regulate your metabolism. But when something goes wrong with your pancreas, the consequences can be devastating.

Some people with long COVID are turning to an unlikely remedy: nicotine gum and patches. Though typically used to quit smoking, nicotine is now being explored as a possible way to ease symptoms such as brain fog and fatigue.

Programs delivering fluoride varnish in schools significantly reduce cavities in children. That is a key finding of our recently published study in the American Journal of Preventive Medicine.

When pain strikes from multiple sources—such as a paper cut followed by contact with hot water—the experience can feel disproportionately intense. But is this agony merely additive, or does the brain integrate these signals in a way that amplifies suffering?

Mitochondria have primarily been known as the energy-producing components of cells. But scientists are increasingly discovering that these small organelles do much more than just power cells. They are also involved in immune functions such as controlling inflammation, regulating cell death and responding to infections.

Washington State University and Mayo Clinic researchers have developed an electrochemical catheter hub that could someday help prevent deadly central line-associated bloodstream infections (CLABSIs) that annually kill thousands of people around the world.

Salivary gland toxicity from radiopharmaceutical therapy—particularly from alpha-emitting therapies like 225Ac-PSMA—is a critical dose-limiting side effect, often leading to debilitating dry mouth. Prior attempts to alleviate dry mouth using cold packs, single anticholinergics, or external cooling have shown minimal protective benefit.

There's nothing better than an ice cold drink on a hot day but imagine this—you're enjoying a refreshing iced tea, and suddenly, your heart starts racing erratically. You might think—"maybe its the caffeine"—until it happens again, this time with a lemonade. It may sound strange, but for some people, cold drinks may be to blame for sudden episodes of atrial fibrillation (Afib), a common heart rhythm disorder.

If spending time around dogs or cats makes your eyes water, your nose run, your skin itch or your breathing difficult, you're not alone.