New insights into chronic inflammation in rheumatoid arthritis

"Mister. Would you like to play a game with me?" These seemingly innocuous words to debt-ridden Gi-hun (Lee Jung-Jae) by a mysterious recruiter (Gong-Yoo) lead him to an opportunity for financial salvation—at the expense of human lives, including possibly his own.

A new international study presented today at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) reveals that IVF cycles involving male partners over the age of 45 carry significantly increased miscarriage risks and lower live birth rates—even when young donor eggs are used.

Low-income patients—and their health care providers—are less likely to challenge denials of their health insurance claims than those with household incomes above $50,000, according to University of Massachusetts Amherst research.

Almost half (47%) of UK adults are worried that they or their loved ones will have a painful or undignified death, according to a survey commissioned by King's College London.

A new ESC Clinical Consensus Statement published in the European Heart Journal discusses the key role of vaccination in preventing cardiovascular events following various viral and bacterial infections.

Northwestern Medicine investigators have identified a surprising culprit in the progression of inflammatory bowel disease: a naturally occurring metabolic compound in the gut, according to a study published in Nature Immunology.

Depression and anxiety are the most common psychiatric disorders in the world. Around 300 million people suffer from depression, whereas 301 million have anxiety disorder. That's nearly 8% of the global population. Unfortunately, many of these people are prescribed drugs that have no effect when they first visit their doctor. Nearly half of all patients experience no effect of the drugs first given to them, making recovery a lengthy affair, lasting weeks or sometimes months.

Diets rich in phosphate additives, commonly found in processed foods, can increase blood pressure by triggering a brain signaling pathway and overactivating the sympathetic nervous system that regulates cardiovascular function, UT Southwestern researchers discovered. Their findings could lead to treatment strategies for patients with hypertension caused by overconsumption of foods containing high levels of phosphates.

Dr. Jason Kim and Dr. Steven Weissbart of the Women's Pelvic Health and Continence Center at Stony Brook University Hospital (SBUH) have successfully performed one of the nation's first—and the East Coast's very first—Glean Urodynamics procedures using Bright Uro's ambulatory urodynamic system.

Wavefront shaping is a promising approach to deep tissue imaging. Until now, it was possible only via an invasive approach: fluorescent points were manually inserted into the sample, and the tissue was indirectly mapped by imaging them. That process has many disadvantages, and it was clear that direct imaging of the tissue is a better way.

Senescent cells, which are damaged and inflammatory, contribute significantly to aging. Researchers at the Max Planck Institute for Biology of Aging have found that worms can enter a senescent-like state, similar to that observed in mammals. This discovery provides a simple yet powerful model to study senescence at the whole organism level, enabling the identification of new ways to prevent or reverse senescence. Published in Nature Aging, these findings hold promise for developing therapies targeting age-related conditions and cancer dormancy.

When Novak Djokovic limped out of the 2024 French Open with a torn meniscus in his knee, all eyes turned to whether he'd be fit for Wimbledon. And when Nick Kyrgios pulled out of Wimbledon for the third year running earlier this month due to a knee injury, fans were disappointed, but medical experts may not have been surprised.

An engineered protein turns off the kind of immune cells most likely to damage tissue as part of type-1 diabetes, hepatitis, multiple sclerosis, shows a new study in mice.

"He hides his smile in every school photo," Jayden's mother told me, holding up a picture of her 6-year-old son.

Because aging weakens cognitive skills, older people can struggle to read difficult social cues. A brain region involved in attention and arousal—the locus coeruleus (LC)—helps with complex tasks, and its connections to the cortex may adapt as humans age to support cognition.

How does the human brain track emotions and support transitions between these emotions? In a new eNeuro paper, Matthew Sachs and colleagues, from Columbia University, used music and an advanced approach for assessing brain activity to shed light on the context dependence and fluctuating nature of emotions.

In a world flooded with fitness fads and "quick-fix" workout plans, solid evidence can often get drowned out. Yet the science is clear: jogging for just five to ten minutes a day can lower your risk of dying from heart disease and even reduce your overall risk of dying from any cause. This kind of research rarely gets the attention it deserves.

Many of us have gotten into the habit of listening to podcasts, audiobooks and other online content at increased playback speeds. For younger people, it might even be the norm. One survey of students in California, for instance, showed that 89% changed the playback speed of online lectures, while there have been numerous articles in the media about how common speedy viewing has become.