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Not all ALK fusions act the same: Variants influence treatment success in lung cancer

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  • 2025-09-24 01:09 event
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Not all ALK fusions act the same: Variants influence treatment success in lung cancer
About 5% of lung adenocarcinomas, one of the most common forms of lung cancer, are driven by a faulty fusion of two genes, EML4 and ALK. This fusion results in different variants, and until now, clinicians have treated all patients with these fusions the same way.

10. Brain narrows focus from broad visual cues to fine details, study shows

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How we focus our attention before we even see an object matters. For example, when we look for something moving in the sky, our expectation would be very different if the object is a bird flying past or a baseball coming straight at us.

11. Valley fever is spreading across the arid West, affecting people and dogs

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In the den of his small apartment in Stockton, 56-year-old Rex Dangerfield sits at a table. The walls are bare, and the space stripped down to essentials. The T-shirt he wears, stamped with the words "I am a Survivor," drapes loosely over his narrow frame. When he walks to his kitchen, his steps can be uncertain.

12. Pre-K and elementary school students have highest virus detection rates

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More than 80% of pre-kindergarten (pre-K) to 12th-grade students and staff have at least one respiratory virus detected and acute respiratory illness (ARI) episode, according to a study published in Pediatrics.

13. GLP-1 receptor agonists improve glycemic and weight outcomes in children with type 2 diabetes, finds study

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In children and adolescents with type 2 diabetes (T2D) or obesity, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) improve glycemic, weight, and cardiometabolic outcomes, according to a study published in JAMA Pediatrics.

14. FDA to approve new use of cancer drug for autism symptoms in kids

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A decades-old cancer drug may soon be approved to help kids with certain autism-related symptoms linked to folate deficiency.

15. Brain abnormalities seen in epilepsy patients with psych comorbidities

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Epilepsy patients with versus without psychiatric comorbidities have a higher proportion of abnormal brain magnetic resonance imaging and electroencephalogram findings, according to a study published in The Journal of Craniofacial Surgery.

16. Diamond power could be a medical implant's best friend

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RMIT researchers have created an experimental 3D-printed diamond–titanium device that generates electricity from flowing liquid and receives wireless power through tissue making it possible to remotely sense changes in flow.

17. Study uncovers crucial role of prostacyclin in fetal membrane healing

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When a pregnant woman's water breaks too early, it often leads to preterm birth, with no effective method to prevent or treat it. Researchers have discovered that the lipid molecule prostacyclin plays a key role in the repair of fetal membrane rupture.

18. Scientists identify neural basis for energy expenditure in arcuate hypothalamus

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In a new discovery, researchers from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences have identified a previously underexplored population of hypothalamic neurons that plays a pivotal role in regulating energy expenditure.

19. Not all ALK fusions act the same: Variants influence treatment success in lung cancer

  • 4 hours ago schedule
  • medicalxpress.com language

About 5% of lung adenocarcinomas, one of the most common forms of lung cancer, are driven by a faulty fusion of two genes, EML4 and ALK. This fusion results in different variants, and until now, clinicians have treated all patients with these fusions the same way.

20. Deadly drug-resistant fungus spreading rapidly through EU hospitals

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A new European health survey shows that Candidozyma auris—a dangerous drug-resistant fungus—is spreading rapidly in hospitals across the continent. Cases and outbreaks are increasing, with some countries now seeing ongoing local transmission.

21. Mindfulness won't burn calories, but it might help you stick with your health goals

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Most people know roughly what kind of lifestyle they should be living to stay healthy.

22. South Africa's rooibos tea: Can it improve digestion?

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Rooibos tea, a caffeine-free drink made from the leaves of a shrub indigenous to South Africa, is part of the country's heritage.

23. People with schizophrenia were hit hard by BC's deadly 2021 heat dome

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In June 2021, British Columbia experienced an extreme climate event. A heat dome trapped hot air over the province, pushing temperatures to record highs for several days, killing more than 600 people.

24. Some new drugs aren't actually 'new': Pharmaceutical companies exploit patents and raise prices

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Pharmaceutical innovation saves lives. But not every "new" drug is truly new.

25. Studies explore how AI tracks breathing, predicts air quality

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In two recent studies, University of Texas at Dallas researchers demonstrated how artificial intelligence (AI) and machine learning can be used to address a variety of issues from a social science policy perspective.

26. Fish oil supplements may not work for certain cancer patients

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About 19 million American adults consume dietary fish oil supplements. These supplements, which primarily consist of the omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid, are widely used as a remedy for chronic diseases. However, the effects of EPA and DHA supplementation on cancer risk have been inconsistent.

27. WHO sees no autism links to Tylenol, vaccines

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Neither the painkiller Tylenol nor vaccines have been shown to cause autism, the World Health Organization said on Tuesday, following comments from the US president and his administration to the contrary.

28. Sugar fingerprints offer faster, more reliable diagnoses for fungal infections

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Hospitals worldwide, including Germany, face a growing problem with fungal infections, with an estimated 6 million cases and 3.8 million deaths each year. According to the World Health Organization (WHO), Candida—a common fungus most people encounter at least once in life—is a top concern. While many know it from mild, superficial infections such as thrush, Candida (especially C. auris and C. albicans) can also reach the bloodstream and cause life-threatening disease.

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