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Novel immunotherapy targets common cancer mutation, offering hope for lung and prostate cancer patients

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  • 2025-09-29 21:11 event
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Novel immunotherapy targets common cancer mutation, offering hope for lung and prostate cancer patients
Researchers at the University of Oslo and Oslo University Hospital have developed a promising new immunotherapy targeting the CTNNB1 gene mutation associated with various aggressive cancers such as lung and prostate cancer. This approach has effectively eliminated tumors in animal studies and could benefit thousands of patients with this mutation. Published in Nature Immunology, the study represents a significant breakthrough in T-cell receptor (TCR) therapy.

17. How much does it hurt? New research puts a price on pain to improve measurement

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Asking people how much money they would accept to experience pain again can provide a more accurate and comparable measure of pain levels than the familiar 1–10 scale, according to an international research team led by Lancaster University.

18. Motivational support and text messages boost proper child car seat use, clinical trial finds

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Parents improved their use of appropriate child car seats after remote motivational counseling and mobile-based support, according to the results from a randomized clinical trial published in JAMA Network Open. The intervention included tailored web content, periodic text messages and personalized feedback on photos parents submitted every four to six weeks showing how their child usually travels in a car.

19. Reform of federal drug discount program should target misaligned incentives, researchers say

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The dramatic growth of a key federal drug discount program has fueled debate about whether it is helping low-income patients as intended or primarily benefiting health care providers.

20. Study shows HPV vaccine protects vaccinated and even unvaccinated women

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A large, long-term study led by an Albert Einstein College of Medicine researcher has found that the introduction of the human papillomavirus (HPV) vaccine in community settings is highly effective in protecting young women from infections caused by the cervical-cancer-causing virus—including women who didn't even receive the vaccine. The study was published today in JAMA Pediatrics.

21. HIV mystery uncovered: How the virus reprograms host cells to create perfect hiding places

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For over three decades, HIV has played an elaborate game of hide-and-seek with researchers, making treating—and possibly even curing—the disease a seemingly insurmountable obstacle to achieve.

22. Long-term at-home adaptive deep brain stimulation found to be effective in Parkinson's disease

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The Department of Neurology and Neurological Sciences at Stanford University School of Medicine, together with multiple academic medical centers and one industry partner (Medtronic) across the US, Canada, Europe, and Jordan, reports that long-term at-home adaptive deep brain stimulation was tolerable, effective, and safe in people with Parkinson's disease previously stable on continuous stimulation.

23. Remote health care helps heart failure patients get the right medications faster

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For millions of Americans living with heart failure, getting the right medications at the right doses can be a slow and frustrating process, which can lead to delayed treatment adjustments, undertreatment and risks for worsening symptoms.

24. Parents of kids with autism sort through new federal recommendations

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Rose Baumann would be the first to say that there's a need for more government attention to autism.

25. Q&A: Autism and Tylenol

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The federal administration offered health guidance at a press conference this week, urging pregnant women to avoid using the over-the-counter painkiller acetaminophen, marketed in the U.S. as Tylenol, saying use of the medication is associated with a higher risk of having children with autism spectrum disorder, or ASD.

26. Novel immunotherapy targets common cancer mutation, offering hope for lung and prostate cancer patients

  • 3 hours ago schedule
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Researchers at the University of Oslo and Oslo University Hospital have developed a promising new immunotherapy targeting the CTNNB1 gene mutation associated with various aggressive cancers such as lung and prostate cancer. This approach has effectively eliminated tumors in animal studies and could benefit thousands of patients with this mutation. Published in Nature Immunology, the study represents a significant breakthrough in T-cell receptor (TCR) therapy.

27. How our health information could be used to criminalize us

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In July, the Trump administration unveiled two policies: the "Making Health Technology Great Again" initiative and the executive order "Ending Crime and Disorder on America's Streets." At first glance, one seems aimed at health care modernization and the other at public safety. But beneath their branding lies a shared infrastructure (and agenda) that poses a profound threat to the civil rights, privacy and bodily autonomy of millions of Americans.

28. Blood-brain barrier remains resilient in widely used Alzheimer's disease model, challenging previous assumptions

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A team of scientists at Texas Tech University Health Sciences Center (TTUHSC) has published new evidence suggesting that the brain's protective shield—known as the blood-brain barrier (BBB)—remains largely intact in a commonly used mouse model of Alzheimer's disease. The discovery challenges long-standing assumptions that Alzheimer's disease causes the BBB to "leak," potentially reshaping how researchers think about drug delivery for the disease.

29. Childhood overeating can be a harbinger of later mental health struggles in girls

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Girls who overeat regularly in the preschool years are more likely to experience anxiety, impulsivity and hyperactivity in adolescence, according to a new study led by researchers at McGill University and the Douglas Research Center.

30. Acetaminophen use during pregnancy does not increase risk of autism, say experts

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Experts at the London School of Hygiene & Tropical Medicine (LSHTM), who have studied the interactions between medications and health for more than a decade, have joined scientists and health care professionals globally to reassure the public that it is safe to take acetaminophen as recommended during pregnancy.

31. Over 99% have a risk factor before heart attack, stroke or heart failure, large-scale study finds

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More than 99% of people who went on to suffer a heart attack, stroke or heart failure already had at least one risk factor above optimal level beforehand, reports a large-scale study led by Northwestern Medicine and Yonsei University in South Korea.

32. Trump says research links Tylenol with autism—scientists say their paper is being misinterpreted

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During this week's White House press conference in which President Donald Trump named the over-the-counter drug Tylenol as a possible cause of rising autism rates, he did not mince words, urging pregnant women to "fight like hell" not to take it.

33. Eating fruit may reduce the effects of air pollution on lung function

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Eating fruit may reduce the effects of air pollution on lung function, according to research presented at the European Respiratory Society Congress in Amsterdam, the Netherlands.

34. Many older adults—especially Gen X women—show signs of addiction to ultra-processed foods

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They were the first generation of Americans to grow up with ultra-processed foods all around them—products typically loaded with extra fat, salt, sugar and flavorings. They were children and young adults at a time when such products, designed to maximize their appeal, proliferated.

35. Why mamba snake bites worsen after antivenom

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A breakthrough study at the University of Queensland has discovered a hidden dangerous feature of the black mamba, one of the most venomous snakes in the world.

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