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'One gene, one disease' no more: Acknowledging the full complexity of genetics could improve and personalize medicine

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  • 2025-10-08 02:53 event
  • 4 hours ago schedule
'One gene, one disease' no more: Acknowledging the full complexity of genetics could improve and personalize medicine
Genetic inheritance may sound straightforward: One gene causes one trait or a specific illness. When doctors use genetics, it's usually to try to identify a disease-causing gene to help guide diagnosis and treatment. But for most health conditions, the genetics is far more complicated than how clinicians are currently looking at it in diagnosis, counseling and treatment.

7.627. This $16 French Moisturizer Is Amazon’s Best-Kept Beauty Secret

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The Embryolisse Lait-Crème Concentré is a multi-tasking hidden gem of a facial cream.View Entire Post ›

7.628. Lila Moss Opened Up About What It Was Like Being Diagnosed With Type 1 Diabetes

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After the model opened up about her experience being diagnosed with type 1 diabetes, we asked experts about the autoimmune condition, the differences between type 1 and type 2 diabetes, and how this diagnosis can change your life.View Entire Post ›

7.629. Why Reviewers Swear By This $28 Tool For Back Pain Relief

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An acupuncturist explains how this scary-looking acupressure mat can help relieve back pain.View Entire Post ›

1. Study highlights risks of cesarean births to future pregnancies

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Women who have cesarean births at an advanced stage of labor are about eight times more likely to develop scars in the womb which are known to increase the likelihood of premature births in future pregnancies, UCL researchers have found.

2. Calorie labeling linked to 2% average reduction in energy content of menu items

  • 54 minutes ago schedule
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Calorie labeling, which became law in April 2022 in England, is associated with only a small (2%) average reduction in the energy content of food that is available away from home, finds research published in the open access journal BMJ Public Health.

3. Whole genome sequencing could match more breast cancer patients to tailored therapies and trials

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Whole genome sequencing offered to breast cancer patients is likely to identify unique genetic features that could either guide immediate treatment or help match patients to clinical trials, say scientists at the University of Cambridge. Their research is published in The Lancet Oncology.

4. Exercise 'snacks' may boost cardiorespiratory fitness of physically inactive adults

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Exercise "snacks"—intentional short bursts of physical activity—may be an effective way of boosting the cardiorespiratory fitness of physically inactive adults, finds a synthesis of the available research, published online in the British Journal of Sports Medicine.

5. Widely-prescribed opioid painkiller tramadol not significantly effective for easing chronic pain, analysis finds

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The strong opioid painkiller tramadol is not significantly effective at easing the chronic pain for which it's widely prescribed, finds a pooled data analysis of the available research, published in BMJ Evidence-Based Medicine.

6. GLP-1 agonists pose emerging challenge for PET-CT imaging, study finds

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The growing use of GLP-1 receptor agonists may affect the interpretation of oncological FDG PET-CT scans, new research presented today at the 38th Annual Congress of the European Association of Nuclear Medicine (EANM 2025) has revealed.

7. 'One gene, one disease' no more: Acknowledging the full complexity of genetics could improve and personalize medicine

  • 4 hours ago schedule
  • medicalxpress.com language

Genetic inheritance may sound straightforward: One gene causes one trait or a specific illness. When doctors use genetics, it's usually to try to identify a disease-causing gene to help guide diagnosis and treatment. But for most health conditions, the genetics is far more complicated than how clinicians are currently looking at it in diagnosis, counseling and treatment.

8. Health centers face risks as government funding lapses

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About 1,500 federally-funded health centers that serve millions of low-income people face significant financial challenges, their leaders say, as the government shutdown compounds other cuts to their revenue.

9. The mental toll of menopause: What women really feel

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Hormonal changes during menopause can drive suicidal thoughts—a crisis that health care services have failed to recognize or adequately address. The devastating link is laid bare in research my colleagues and I conducted recently.

10. Uncovering hidden risk factors: Sleep-related leg movements and diabetes

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Restless nights can take a toll that goes beyond next-day tiredness. Sleep influences nearly every aspect of our health, and chronic disruptions to sleep patterns have been linked to increased risks for different diseases. To further investigate this connection, a recent study published in Cureus explored the association between sleep-related leg movements and diabetes.

11. Lesser-known lobular breast cancer on the rise in U.S. women

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The American Cancer Society has released a report on occurrence and outcomes in the United States for this subtype of breast cancer. Findings show an estimated 33,600 women will be diagnosed with lobular breast cancer or invasive lobular carcinoma (ILC) this year.

12. Glycoprotein shows potential for treating both 'leaky gut' and severe depression

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What if a protein could be injected to help heal both "leaky gut" and severe depression? New research from the University of Victoria (UVic), published in Chronic Stress, shows that a glycoprotein called reelin may one day be able to do just that.

13. Depression genetics differ by sex: Study find females carry higher risk than males do

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Important genetic differences in how females and males experience depression have been revealed for the first time in findings that could pave the way for more targeted intervention and treatments.

14. Disabling a critical cellular pathway could be key to stopping deadly rotavirus infection

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Rotavirus causes severe dehydrating diarrhea in infants and young children, contributing to more than 128,500 deaths per year globally despite widespread vaccination efforts. Although rotavirus is more prevalent in developing countries, declining vaccination uptake in the United States has resulted in increasing cases in recent years.

15. Sleep patterns linked to variation in health, cognition, lifestyle and brain organization

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Researchers led by Aurore Perrault at Concordia University, Canada and Valeria Kebets at McGill University, Canada, have used a complex data-driven analysis to uncover relationships among multiple aspects of sleep and individual variation in health, cognition, and lifestyle.

16. Efforts to suppress or change gender identity prove ineffective and harmful, Australian research indicates

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Efforts to suppress or change a child's gender identity and sexuality are ineffective and cause long-term harm, according to new research.

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