Pan-disease atlas maps molecular fingerprints of health, disease and aging

Researchers at the Francis Crick Institute and Vividion Therapeutics have identified chemical compounds that can precisely block the interaction between the major cancer-driving gene RAS and a key pathway for tumor growth.

A team of researchers at the University of Kentucky Sanders-Brown Center on Aging now have a better understanding of how the brain's support cells communicate with blood vessels—a process that goes awry in Alzheimer's disease.

Two new studies by the Leibniz Institute for Prevention Research and Epidemiology–BIPS in Bremen show for the first time that air quality directly influences blood pressure (pre-hypertension and hypertension) and important markers for diabetes risk in children and adolescents. These findings were made possible by the use of causal inference methods to determine the effects of hypothetical interventions.

Ticks are found all over the world. There are more than 900 species, and many of them pass on dangerous diseases to both humans and animals.

Except for one key aspect, the setup is a familiar one in medicine: An expert diagnostician presents a particularly challenging case to a roomful of colleagues, carefully walking them through the patient's symptoms and initial test results. The physician explains her reasoning in detail as she breaks down the case and every possibility she considered, aided by a slide deck. At the end of the five-minute talk, she reveals her diagnosis and the next steps she would recommend.

Even though electronic cigarettes do not contain any illicit substances, the liquid can cause serious health problems. Often, the nicotine concentration in these products is several times higher than in conventional cigarettes, promoting rapid addiction.

While stuttering was believed to have purely psychological causes up until about 30 years ago, scientists today attribute it to a variety of factors capable of contributing to its development. For instance, several genes have been identified that increase the risk of stuttering, and anatomically, the brains of individuals with speech flow disorders show differences in neural connections and brain activity compared to those who speak fluently.

Today, my laboratory looks more like a scene from a sci-fi film than a psychology research space. Wires snake across tables, sensors lay carefully arranged on trays, and a bucket of ice water sits in the corner, quietly waiting its turn.

For many parents with young children, getting back into a running routine means dragging out the jogging stroller. While it's no surprise that pushing a bulky three-wheeler can feel harder and change the way you run, a new study led by researchers from Penn State Berks found that runners experience less impact per step, reducing their overall risk for injury.

A council of five AI models working together, discussing their answers through an iterative process, achieved 97%, 93%, and 94% accuracy on 325 medical exam questions spanning the three stages of the U.S. Medical Licensing Examination (USMLE), according to a study published in PLOS Medicine by researcher Yahya Shaikh of Baltimore, U.S., and colleagues.

The ticking of the biological clock is especially loud in the ovaries—the organs that store and release a woman's eggs. From age 25 to 40, a woman's chance of conceiving each month decreases drastically.

Tumors are not a comfortable place to live: oxygen deficiency, nutrient scarcity, and the accumulation of sometimes harmful metabolic products constantly stress cancer cells.

Elevated calcium levels in the blood—a complication of kidney cancers known as hypercalcemia—may be successfully treated with a class of medications called HIF-2α inhibitors developed by UT Southwestern Medical Center, a new study shows. The findings, published in Cancer Discovery by a team at UTSW, offer hope to patients who develop this condition.

Dr. Ahmed Lawan, an assistant professor in the College of Science at The University of Alabama in Huntsville (UAH), a part of The University of Alabama System, has published a paper in the journal Cells that demonstrates there is a potential gender component in the development of diabetes as it relates to the function of a particular enzyme.

Shame can lead people to avoid getting treatment for dental issues, potentially worsening oral health inequalities, a new study warns.

In the United States, significant numbers of adults with dementia require long-term care services. For example, around 750,000 people who live in nursing homes have a diagnosis of dementia. However, transportation insecurity for this population has not received sufficient attention. Although long-term care facilities provide basic medical services, residents with dementia often need external, preventative, and follow-up care such as specialist visits, diagnostics, and dental or vision services. Without reliable nonemergency medical transportation, these needs may go unmet.

Whether and when to use the label "dyslexia" has been a perennial debate in education.

University of Arizona researchers may have uncovered a connection between chronic pain and a somewhat uncommon immune condition, opening the door to future research on immune biomarkers for chronic pain.