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Portable tuberculosis test achieves 100% sensitivity and specificity in clinical samples

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  • 2025-08-12 21:40 event
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Portable tuberculosis test achieves 100% sensitivity and specificity in clinical samples
Princeton University and collaborators have developed SHINE-TB, a one-sample, parallelized reaction amplification and detection CRISPR assay that detects Mycobacterium tuberculosis directly from sputum, achieving 100% sensitivity (6 of 6) and 100% specificity (7 of 7) versus culture in 13 blinded clinical samples.

281. World's first wireless OLED contact lens for retinal diagnostics developed

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Electroretinography (ERG) is an ophthalmic diagnostic method used to determine whether the retina is functioning normally. It is widely employed for diagnosing hereditary retinal diseases or assessing retinal function decline.

282. Job dissatisfaction and burnout may be behind exodus of GPs

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Burnout and job dissatisfaction are likely to be key drivers influencing GPs' decisions to leave patient care within the next five years, University of Manchester researchers have found.

283. Summer COVID surge continues as wastewater levels rise, CDC says

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The summer surge of COVID-19 continues with new federal data showing the virus is on the rise in many parts of the country.

284. Update: NYC Legionnaires' outbreak grows to 90 cases; 3 deaths reported

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A Legionnaires' disease outbreak in Central Harlem has now sickened 90 people and caused three deaths, New York City health officials said Tuesday.

285. Autoimmune diseases linked to cancers of the digestive tract

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In a comprehensive study, researchers from the Department of Epidemiology at the Faculty of Medicine at the University of Augsburg have provided reliable evidence for a link between chronic inflammatory diseases and the development of tumors in the digestive tract. The results were recently published in eClinicalMedicine.

286. Neural navigation: Engineers map brain's smallest blood vessels using computer models

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Healthy brain function relies on a steady supply of blood. Disruptions in blood flow are linked to major neurological conditions like stroke, Alzheimer's disease (AD), and traumatic brain injuries. But understanding how the brain fine-tunes this flow—especially across its smallest blood vessels—remains a challenge.

287. Gambia baby death heightens alarm over female genital mutilation

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Rights activists in The Gambia are calling for justice after a one-month-old baby's death was linked to female genital mutilation, a widely practiced but illegal procedure up for review before the country's Supreme Court.

288. The stomach's 'second brain' is more in sync with the mind during mental distress, researchers discover

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Stronger coordination between the brain and the stomach's natural rhythm is linked to higher levels of anxiety, depression, and stress, according to the largest study of its kind from Aarhus University.

289. What exactly is long COVID? Different definitions lead to widely varying estimates

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What is long COVID? Despite hundreds of published studies and millions affected worldwide, the medical field still lacks a clear answer.

290. Portable tuberculosis test achieves 100% sensitivity and specificity in clinical samples

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Princeton University and collaborators have developed SHINE-TB, a one-sample, parallelized reaction amplification and detection CRISPR assay that detects Mycobacterium tuberculosis directly from sputum, achieving 100% sensitivity (6 of 6) and 100% specificity (7 of 7) versus culture in 13 blinded clinical samples.

291. Synthetic drugs are having devastating effects around the world, from Sierra Leone to the UK

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In the blistering heat of Freetown, Sierra Leone, young men gather on street corners, their limbs swollen, eyes glazed. They are the victims of kush, a cheap and deadly synthetic drug sweeping the country.

292. Weight loss support before IVF could boost pregnancy chances—and reduce the need for treatment

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Around 1 in 5 women of childbearing age are living with [obesity], defined by the World Health Organization as having a body mass index (BMI) over 30 kg/m². Compared with women in the healthy BMI range (18.5–24.9 kg/m²), those living with obesity are three times more likely to experience fertility problems and nearly twice as likely to have a miscarriage. Many turn to in vitro fertilization (IVF) in the hope of having a baby.

293. From clear skin to detoxing, chlorophyll and collagen supplements promise a lot, but what does the science say?

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Walk into any health store, scroll through TikTok, or browse the shelves of your favorite beauty retailer, and you'll be met with a familiar promise: that a pill, powder or potion could be the secret to glowing skin, boosted energy, or even inner "detoxification." Among the most hyped are chlorophyll—the green pigment in plants now found in trendy waters and tinctures—and collagen, the protein hailed as the holy grail for youthful skin and strong joints.

294. Gene therapy can be less effective in women—and my research in mice brings us one step closer to understanding why

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Gene therapies hold immense promise for treating sight loss. These therapies use a modified, harmless virus to deliver therapeutic genes directly to diseased cells, helping them to function normally again.

295. Maternal obesity linked to autism-like behaviors in offspring

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In a study conducted at the University of Hawaiʻi at Mānoa, researchers from the John A. Burns School of Medicine (JABSOM) have uncovered a mechanistic link between maternal obesity prior to pregnancy and autism-related behavioral outcomes in offspring.

296. Why common cuff-based blood pressure readings may be misleading—and how to fix them

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Researchers have found why common cuff-based blood pressure readings are inaccurate and how they might be improved, which could improve health outcomes for patients.

297. AI challenge models can independently interpret mammograms

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Algorithms submitted for an AI Challenge hosted by the Radiological Society of North America (RSNA) have shown excellent performance for detecting breast cancers on mammography images, increasing screening sensitivity while maintaining low recall rates, according to a study published in Radiology.

298. How chronic inflammation related to alcohol consumption accelerates pancreatic cancer development

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Despite increasing evidence linking alcohol consumption to cancer, little is known about the biological mechanisms behind the association.

299. You handle your child's allergies and asthma at home: Who's in charge at school?

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It wasn't easy—and may have taken a few tries—but your child's asthma and allergies are well-managed at home. But what about their health at school? How do you make sure allergy and asthma flares don't happen away from home during the day?

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