Potential anti-breast cancer drug identified

The adoption of the WHO Pandemic Agreement by the World Health Assembly on 20 May 2025 was a landmark moment in global health.

An international study has, for the first time, revealed a strong and direct link between the rise of antibiotic-resistant bacteria and universal disinfection procedures applied to patients in intensive care units. Published in The Lancet Microbe, the study calls for a reassessment of health care guidelines on the widespread use of disinfectants.

Scientists from the A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a new artificial intelligence (AI)-based method called "Fragle" that makes tracking cancer easier and faster using blood tests.

Myelodysplastic syndromes (MDS) are a group of disorders that typically arise in adulthood, especially after the age of 70, and their five-year survival rate is around 30%. MDS are characterized by defective maturation of blood cells in the bone marrow, leading to a range of health problems such as fatigue and recurrent infections. Without appropriate treatment, they may progress to acute myeloid leukemia, a much more severe disease.

AI guidance for clinicians aimed at reducing the spread of Clostridioides difficile—a bacteria that can be deadly for sick patients—was deployed for the first time in a hospital setting, according to a University of Michigan-led study published in JAMA Network Open.

Women with breast cancer who were also carriers of the BRCA1 or BRCA2 mutation and received textured breast implants as part of their reconstructive surgery after mastectomy were 16 times more likely to develop breast-implant-associated anaplastic large cell lymphoma (BIA-ALCL), a rare T-cell lymphoma, compared to similar women without these genetic mutations, according to a study published today in Blood Advances.

An international study has shown that targeted online education on atrial fibrillation (AF) for health professionals can improve guideline-adherent care. This cluster-randomized controlled trial, published in Nature Medicine this week, was designed to test if structured online AF education for health professionals could improve the care that individual patients receive.

In modern immunotherapy, modified immune cells are introduced into the body to attack tumors and other targets. Researchers at the Technical University of Munich (TUM) have developed a method for tracking these cells in the body. This new approach could deepen our understanding of cellular therapies and help make future treatments safer.

For decades, scientists have used near-infrared light to study the brain in a noninvasive way. This optical technique, known as fNIRS (functional near-infrared spectroscopy), measures how light is absorbed by blood in the brain, to infer activity.

Displaced aggression, such as lashing out at an unrelated individual after a frustrating experience, is a well-documented phenomenon in both humans and animals.

City of Hope researchers have co-led the first study to demonstrate that characterizing genetic material near chromosomes forecasts how mutated, cancer-causing genes reengineer DNA and alter the tumor microenvironment. The brain cancer research provides foundational knowledge that could one day improve the practice of precision medicine and allow oncologists to deliver more personalized therapies to cancer patients.

Memorial Sloan Kettering Cancer Center researchers have identified a metabolic switch that determines whether intestinal stem cells become absorptive or secretory cells. Manipulating the enzyme OGDH either fuels cell expansion or redirects fate, with potential consequences for colitis recovery and regenerative therapy.

Stroke remains one of the leading causes of death, disability, increased economic burden and decreased quality of life around the world. Current stroke therapies are time-limited and largely focused on restoring blood flow, and there are few which address the secondary wave of inflammation that causes further injury in the hours and days after stroke.

The horrendous images of the Air India plane that crashed yesterday, killing at least 200 of the 242 people who were aboard, are likely to escalate anxiety among many who have an intense fear of flying, say mental health experts.

A new lab-grown material has revealed that some of the effects of aging in the heart may be slowed and even reversed. The discovery could open the door to therapies that rejuvenate the heart by changing its cellular environment, rather than focusing on the heart cells themselves.

The pharmaceutical industry is vital to human health, but it also has a significant environmental impact.

Chemotherapy is a vital treatment for people with all forms of cancer. It's a process that uses drugs designed to kill, damage or slow the spread of cancer cells, preventing them from growing and dividing.

The cerebral cortex, the outermost layer of the brain, is the central driver of various human capabilities, including decision-making, perception, language and memory. Understanding how the morphology (i.e., structure and shape) of people's cerebral cortex is related to their mental health is a long-standing goal for many neuroscientists, as it could help to predict the risk that people will develop specific neuropsychiatric conditions while also contributing to their diagnosis and potentially informing their treatment.