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Progress in gene therapy offers hope for long-term knee pain relief

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  • 2025-07-30 17:06 event
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Progress in gene therapy offers hope for long-term knee pain relief
For nearly three decades, Mayo Clinic researcher Christopher Evans, Ph.D., has pushed to expand gene therapy beyond its original scope of fixing rare, single-gene defects. That has meant systematically advancing the field through laboratory experiments, pre-clinical studies and clinical trials.

990. Study identifies new target for obesity-related breast cancer

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University of Kentucky Markey Cancer Center researchers have identified a protein that could be a promising treatment target for obesity-related breast cancer.

991. Young men with passive approach to news tend to believe medical misinformation

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True or false?

992. Treating hypertension with single pill combinations saves lives and money

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A new Australian study published in the latest issue of the Journal of Hypertension shows that treating hypertension with single pills combining two or more medications provides effective control and also delivers substantial cost savings to both consumers and payers, when compared with equivalent doses in multiple pills.

993. Wearable device uses ambient light for 24-hour health monitoring

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Miniaturization and weight reduction of medical wearable devices for continuous health monitoring such as heart rate, blood oxygen saturation, and sweat component analysis remain major challenges. In particular, optical sensors consume a significant amount of power for LED operation and wireless transmission, requiring heavy and bulky batteries.

994. How the common fungus Candida albicans colonizes the gut

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About 80% of people have the fungus Candida albicans in their gut. Although most of the time it persists unnoticed for years, causing no health problems, C. albicans can turn into a dangerous microbe that causes serious diseases in many organs, including the urinary tract, lungs and brain. Understanding how this fungus colonizes the gut is key to preventing it from becoming harmful.

995. A single artificially sweetened soft drink daily may increase diabetes risk by more than a third

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An Australian study has found that drinking just one can of artificially-sweetened soft drink a day may increase the risk of developing type 2 diabetes by 38%.

996. Interfacing the nervous system for rehabilitation

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Memory loss, tremors, paralysis: When parts of the nervous system start to break down—or get broken—the consequences for human health can be staggering. Can we fix the nervous system, and how are scientists approaching the problem? We take a deep dive into various strategies for interfacing with the nervous system to restore neuronal function.

997. Over 60? Healthy lifestyle change may help boost your brain

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Two years' involvement in programs focused on healthy eating, regular exercise and "brain training" exercises appears to have helped a wide range of older adults—even those at heightened risk of Alzheimer's—avoid cognitive decline, a new study finds.

998. California looked to them to close health disparities, then it backpedaled

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Fortina Hernández is called "the one who knows it all."

999. Progress in gene therapy offers hope for long-term knee pain relief

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For nearly three decades, Mayo Clinic researcher Christopher Evans, Ph.D., has pushed to expand gene therapy beyond its original scope of fixing rare, single-gene defects. That has meant systematically advancing the field through laboratory experiments, pre-clinical studies and clinical trials.

1.000. Red states lead the charge toward healthier living

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Ever since Donald Trump rode down his golden escalator at Trump Tower in 2015, a political and cultural realignment has been underway in America, culminating in his second presidential victory. Many issues once considered the domain of the left seem to have been adopted by the new, right-leaning populist movement.

1.001. How mHealth app incentives drive health and transit

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Walking is well known to have significant health benefits, but few people achieve the daily recommended steps. Fortunately, mobile health (mHealth) applications have emerged as promising tools to promote physical activity. These apps track user activities on mobile devices to deliver health and wellness services. However, the effectiveness of these apps in increasing daily walking behavior remains underexplored, partly due to variations in their incentive structures.

1.002. New study confirms post-pandemic surge in gut-brain disorders

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A new international study confirmed a significant post-pandemic rise in disorders of gut-brain interaction, including irritable bowel syndrome (IBS) and functional dyspepsia, according to a paper published in Clinical Gastroenterology and Hepatology.

1.003. AI detects the stiffness of cancer cell exosomes, enhancing lung cancer diagnostic accuracy

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A research team has developed a technology that distinguishes lung cancer gene mutations solely by measuring the "stiffness" of exosomes—tiny particles released from cancer cells in the bloodstream—using atomic force microscopy (AFM).

1.004. Genetic study points to neurological mechanisms for chronic cough

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A new genetic study has identified neurological mechanisms as key drivers of chronic cough. The findings significantly advance our biological understanding of the condition, shedding light on potential avenues for new treatments.

1.005. Female pilots perform better under pressure, study finds

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Female pilots may outperform their male counterparts in high-pressure flight situations, according to a new study led by University of Waterloo researchers.

1.006. Study finds cancer cells boost energy to survive mechanical stress and DNA damage

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Cancer cells mount an instant, energy‑rich response to being physically squeezed, according to a study published in the journal Nature Communications. The surge of energy is the first reported instance of a defensive mechanism that helps cells repair DNA damage and survive the crowded environments of the human body.

1.007. Hotel2Hospital: An extreme makeover shows how a patient surge could be handled in a crisis

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When JD Naasz, RN, a UCHealth emergency department nurse, arrived at a big hotel near the University of Colorado Anschutz Medical Campus, he was astounded. "The first day I walked in, I thought, 'This isn't a hotel. This is a hospital,'" he said.

1.008. 'Tongue swallowing prevention maneuvers' delay CPR, could contribute to brain injury or death for collapsed athletes

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Despite widespread public health efforts, the dangerous myth of "prevention of tongue-swallowing" continues to persist during cardiopulmonary resuscitation (CPR). New research in the Canadian Journal of Cardiology exposes the mainstream and social media's detrimental role in perpetuating this misconception, which often leads to critical delays in proper CPR for collapsed athletes.

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