Quebec's hereditary cancer gene linked to one ancestor

The term dementia is used to describe various debilitating neurological disorders characterized by a progressive loss of memory and a decline in mental abilities. Estimates suggest that over 55 million people worldwide are currently living with dementia, and this number could rise further over the next decades.

An experimental mRNA vaccine has boosted the tumor-fighting effects of immunotherapy in a mouse-model study, bringing researchers one step closer to their goal of developing a universal vaccine to "wake up" the immune system against cancer.

As millions of people know firsthand, the most common side effect of mRNA vaccines like the COVID-19 shot is inflammation: soreness, redness and a day or two of malaise. But what if mRNA vaccines could be redesigned to sidestep that response altogether?

In the Canadian town of Aylmer, where Mennonites in traditional dress walk down the main street alongside secular locals, bitter divisions over vaccine skepticism that arose during COVID have intensified with the reemergence of measles.

Vitamin D is not only an essential nutrient, but also the precursor of the hormone calcitriol, indispensable for health. It regulates the uptake of phosphate and calcium necessary for bones by the intestines, as well as cell growth and the proper function of muscles, nerve cells, and the immune system.

Scar tissue in the heart was associated with abnormal heart rhythms among healthy, long-time male endurance athletes aged 50 or older, potentially increasing their risk of sudden cardiac death, according to a small study published in Circulation: Cardiovascular Imaging, an American Heart Association journal.

In a major advance for patients with Crohn's disease, a new study led by researchers at Mount Sinai Health System found that guselkumab, a medication with a mechanism of action that is new to inflammatory bowel disease (IBD) treatment, outperformed an established standard of care in promoting intestinal healing and symptom relief.

Swollen legs led to President Donald Trump being diagnosed with what's called chronic venous insufficiency. It's a fairly common condition among older adults but requires a thorough checkup to rule out more serious causes of swelling in the legs. Here are some things to know.

The odds of patient complications following high-risk surgeries are lower when the surgeon and anesthesiologist have prior experience working together, according to a new study by researchers at ICES, Sunnybrook Research Institute and the University of Toronto.

Three studies presented today at the Society of NeuroInterventional Surgery's (SNIS) 22nd Annual Meeting discussed whether using GLP-1 inhibitors could lessen the impact of stroke and related brain injuries or reduce the risk of stroke altogether. These medications, which lower blood sugar and often cause weight loss, are commonly prescribed for type 2 diabetes and obesity and include drugs like semaglutide (Ozempic).

Long-term obesity is associated with the expression of biomarkers denoting antagonistic and integrative aging hallmarks in adults aged 28 to 31 years, according to a study published online July 11 in JAMA Network Open.

Sickle cell disease can lead to a severe complication known as acute chest syndrome (ACS), but the underlying mechanisms are not well understood.

Delays in diagnosis of hypertension are common and associated with delays in treatment initiation, according to a study published online July 14 in JAMA Network Open.

A new project by a team of researchers across the nation analyzes the ways in which digitized health data, artificial intelligence models and other recent technological advancements have changed how cancers are diagnosed, studied and treated.

Raghu R. Chivukula, MD, Ph.D., a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School, is the senior author of a paper published in Science, titled "Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders."

Researchers at MIT and other institutions have identified compounds that can fight off viral infection by activating a defense pathway inside host cells. These compounds, they believe, could be used as antiviral drugs that work against not just one but any kind of virus.

Guoping Li, Ph.D., of the Department of Anesthesia, Critical Care & Pain Medicine at Massachusetts General Hospital, is the lead author, and Saumya Das, MD, Ph.D., of the Cardiovascular Research Center at Massachusetts General Hospital, is the senior author of a paper published in Science, titled "A hypoxia-responsive tRNA-derived small RNA confers renal protection via RNA autophagy."

While parenthood is linked with better mental health, new UCL research reveals social and economic circumstances also matter.