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Research targets treatment resistance in neuroendocrine tumors

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  • 2025-10-21 15:30 event
  • 6 hours ago schedule
Research targets treatment resistance in neuroendocrine tumors
A novel combination therapy pairing a DNA-synthesis inhibitor with a targeted radiopharmaceutical may improve outcomes for patients with advanced neuroendocrine tumors, according to new clinical trial data presented at the European Society for Medical Oncology (ESMO) Congress 2025.

28. Study unveils mechanisms driving axonal accumulation of TDP-43 and associated nerve damage in ALS

  • 4 hours ago schedule
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscle wasting and limb paralysis. This neurodegenerative condition results from the gradual destruction of motor neurons, the nerve cells that control muscles.

29. Understanding the association between hormone therapy and autoimmune disease risk

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Autoimmune diseases disproportionately affect women, with notable shifts in incidence following menopause, suggesting a potential role of sex hormones in immune regulation.

30. How menopause restructures a woman's brain

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Many women during menopause complain about brain fog, which includes symptoms like forgetfulness, trouble concentrating, and mental fatigue, often due to fluctuating hormone levels. A literature review was conducted to examine published studies that explore the link between structural brain changes during menopause and cognitive, emotional and physiological outcomes.

31. Understanding how menopause symptoms can complicate treatment of traumatic brain injuries

  • 4 hours ago schedule
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Despite growing recognition of sex differences in traumatic brain injury (TBI) outcomes, the interaction between hormone transitions–particularly menopause–and brain injury remains significantly underexplored in both research and clinical care. A new study suggests a greater focus on hormone changes when diagnosing and treating TBIs in menopausal women.

32. Digestive issues more common during perimenopause and menopause, study finds

  • 5 hours ago schedule
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Digestive health issues are highly prevalent among perimenopausal and menopausal women, with many reporting the onset or exacerbation of symptoms during this life stage. Despite symptom burden, formal diagnoses and effective treatment remain limited. That's the conclusion of a new study focused on gut health during the menopause transition.

33. Risk of eye disease increases during menopause transition

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Many symptoms, such as hot flashes and vaginal dryness, are commonly associated with the menopause transition. One of the lesser-known symptoms that worsens in midlife is dry eyes. A new study suggests that postmenopausal women exhibit a higher prevalence of dry eye disease than perimenopausal women.

34. The role of genetics in modifying the link between earlier menopause and memory decline

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Women are significantly more likely than men to develop Alzheimer's disease. Earlier age at menopause is associated with a greater risk for late-life cognitive decline and Alzheimer's disease. A new study suggests that this risk is even higher in women who carry the APOE e4 gene variant or who have systemic inflammation.

35. Review suggests that hormones prescribed during perimenopause or early postmenopause have potential to reduce anxiety

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Anxiety is a common and significant symptom of menopause and perimenopause, largely due to hormone fluctuations. Numerous studies have focused on the potential benefits of hormone therapy in reducing anxiety. A new systematic review indicates the treatment does not consistently impact anxiety symptoms in midlife women. Results of the review were presented at the 2025 Annual Meeting of The Menopause Society in Orlando, held October 21–25.

36. Epigenetic reprogramming safely modifies multiple genes in T cells simultaneously for CAR-T therapies

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Arc Institute, Gladstone Institutes, and University of California, San Francisco, scientists have developed an epigenetic editing platform that enables safe modification of multiple genes in primary human T cells, addressing a key manufacturing and scalability challenge in next-generation cell therapies.

37. Research targets treatment resistance in neuroendocrine tumors

  • 6 hours ago schedule
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A novel combination therapy pairing a DNA-synthesis inhibitor with a targeted radiopharmaceutical may improve outcomes for patients with advanced neuroendocrine tumors, according to new clinical trial data presented at the European Society for Medical Oncology (ESMO) Congress 2025.

38. Stimulating the senses soothes the mind, research confirms

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While the expression "touch grass" is most often used as a meme to teasingly tell fellow internet users to log off and venture outside, there is research-backed evidence that reconnecting with sensory experiences only found in the physical world is highly beneficial for overall well-being.

39. US funding cuts could result in nearly 9 million child tuberculosis cases, 1.5 million child deaths, study suggests

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A new study projects that US funding cuts to global health aid will have a catastrophic effect on pediatric TB, with children in Sub-Saharan Africa and Southeast Asia likely to experience a significant spike in preventable cases and deaths over the next decade—even by the most conservative estimates—unless funding is restored.

40. Climate change, population growth threats as malaria fight stalls

  • 7 hours ago schedule
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The fight against malaria has stalled after two decades of progress, with climate change and population growth among factors threatening a resurgence of the potentially fatal disease, campaigners said Tuesday.

41. Physical activity raises daily calorie burn without conserving energy used elsewhere, study finds

  • 8 hours ago schedule
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The effects of physical activity don't stop when the movement does. In a new study published in the Proceedings of the National Academy of Sciences, Virginia Tech researchers, in collaboration with researchers at the University of Aberdeen and Shenzhen University, have found that being active adds to the total energy you use every day without causing the body to conserve energy in other ways.

42. Rising demands, rising performance: Australian Football League Women's players push limits in finals season

  • 10 hours ago schedule
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As the Australian Football League Women's (AFLW) finals edge closer, players across the league are preparing to push their limits. Now, new research from the University of South Australia shows that AFLW players are pushing their physical limits more than ever before.

43. How happy do we need to be to have lower chronic disease mortality risk?

  • 10 hours ago schedule
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Heart disease, cancer, asthma, and diabetes: All are chronic or non-communicable diseases (NCD), which accounted for about 75% of non-pandemic related deaths in 2021. They may result from genetic, environmental, and behavioral factors, or a combination thereof. But can other factors also influence disease risk?

44. Brainwave study sheds light on cause of 'hearing voices'

  • 10 hours ago schedule
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A new study led by psychologists from UNSW Sydney has provided the strongest evidence yet that auditory verbal hallucinations—or hearing voices—in schizophrenia may stem from a disruption in the brain's ability to recognize its own inner voice.

45. 'Holy grail' blood test for more than 50 cancers brings 'exciting' results

  • 11 hours ago schedule
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A blood test that screens for more than 50 cancers is correct in 62% of cases where it thinks people may have the disease, a study has found.

46. The exercise paradox: Why workouts aren't great for weight loss but useful for maintaining a healthy body weight

  • 14 hours ago schedule
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The basic principle of weight loss is straightforward: if you consume fewer calories than you burn, you'll lose weight. In practice though, this isn't usually so easy or simple.

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