Researchers call for further improvement of hospital discharge summaries

Pancreatic cancer remains one of the biggest challenges in the field of oncology. Numbers of cases are increasing, and the latest personalized therapies and immunotherapy are not yet yielding results. Much of the effort is focused on detecting the tumor as early as possible, because the majority of cases are diagnosed at a late stage. But the research also aims to help make the best clinical decision after diagnosis.

A powder based on morin, a natural compound extracted from plants such as guava leaves, apple and fig peels, certain teas, and almonds, has shown antimicrobial, anti-inflammatory, and antioxidant effects against bacteria that cause periodontal disease. It is expected that the substance, released in a controlled manner through polymers, will help with nonsurgical treatments as an alternative to antibiotics for controlling microorganisms.

Concussion and other traumatic brain injuries impact an estimated 69 million people every year, as a result of sports collisions, falls, road accidents and interpersonal violence. There are few treatments, and no approved and effective pharmacotherapies.

Researchers from the University of Birmingham's Bladder Cancer Research Center have used a new method to detect chemical changes in the DNA in an individual's urine sample; epigenetic changes, called methylation.

A new study by researchers from the University of Birmingham and the University of Turku, Finland has revealed an important clue as to why immunotherapy fails in many patients with cancer.

Researchers in Berlin have used base editing to repair mutations that cause the kidney disorder ADPKD in cells from both mice and humans. In mice, a team led by Michael Kaminski was able to ease a key symptom of the difficult-to-treat disease.

In the cancer type multiple myeloma, the malignant cells differ significantly from normal cells regarding the layer of chemical "tags" on DNA and proteins that control whether genes are turned on or off. These "tags" affect growth and survival of the tumor cells, and could be utilized for developing new treatment strategies against multiple myeloma.

A research team led by Prof. Wang Yi and Wei Haiming from the University of Science and Technology of China (USTC), in collaboration with Prof. Ding Chen's team from Human Phenome Institute at Fudan University, has elucidated the role of lactate-induced lysine lactylation (Kla) in modulating natural killer (NK) cell anti-tumor responses within the tumor microenvironment (TME). The study was published in Nature Immunology on June 10.

A new study reveals that small cell lung cancer (SCLC) likely begins in basal stem-like cells rather than in neuroendocrine cells, marking a major shift in the understanding of this aggressive disease that is often associated with smoking.

An international study led by Dr. Malu Martínez-Chantar, principal investigator at CIC bioGUNE and CIBERehd, has identified a new therapeutic target for cholangiocarcinoma (CCA), a rare but highly aggressive liver cancer with very limited treatment options. The findings, recently published in the journal Gut, open the door to developing safe and effective personalized therapies. Importantly, the study has been highlighted with a dedicated editorial. The work was carried out with Dr. Naroa Goikoetxea and Dr. María Mercado as co–first authors, in collaboration with several international research centers.

People with temporal lobe epilepsy in particular often wander around aimlessly and unconsciously after a seizure. Researchers at the University Hospital Bonn (UKB), the University of Bonn, and the German Center for Neurodegenerative Diseases (DZNE) have identified a neurobiological mechanism that could be responsible for this so-called post-ictal wandering and potentially other postictal symptoms.

Musical people find it easier to focus their attention on the right sounds in noisy environments.

New York City offers nearly every type of medical specialist but provides fewer specialty health care providers per capita than smaller cities, according to a new study that challenges conventional assumptions about urban health care advantages and reveals a troubling paradox across America's largest metropolitan areas.

In a pair of studies, investigators from the lab of Huiping Liu, MD, Ph.D., associate professor of Pharmacology and of Medicine in the Division of Hematology and Oncology, have uncovered how specific cellular interactions in the bloodstream may be fueling the spread of breast cancer.

In a study led by Lund University and the Amsterdam University Medical Center, researchers used PET to analyze aggregates of tau pathology in more than 12,000 people from all over the world. The study—the largest ever of its kind—examines the connection between genetic predisposition, gender and age in relation to tau pathology in Alzheimer's disease. The study is published in Nature Neuroscience.

Pancreatic cancer has the highest mortality rate of all major cancers, and its incidence is climbing. Because it is typically asymptomatic at early stages, pancreatic cancer is especially difficult to catch and treat in time. This allows the cancer to spread or metastasize throughout the body—the ultimate cause of death for nearly all patients.

In an analysis by race, sex, age, and geography, alcohol-induced death rates in 2024 are nearly double those in 1999, with a sharp increase at the onset of the COVID-19 pandemic.

People with substance use disorder who participate in recovery running programs have shown improved success in maintaining their sobriety and reducing their risk for relapse. These observations led Panayotis Thanos, a University at Buffalo neuroscientist who studies the brain's reward system, to try to figure out the brain mechanisms behind that phenomenon.