Researchers identify instances of SYNGAP1-related disorders caused by inherited genetic variants

Scientists at St. Jude Children's Research Hospital and Dana-Farber Cancer Institute today report the identification of a novel combination therapy approach to treat pediatric acute myeloid leukemia (AML). Standard treatment is often ineffective against AML, a cancer that commonly relapses with poor prognosis, particularly when the disease is fueled by fusion proteins involving NUP98.

Period-tracking apps are popular digital tools for a range of menstrual, reproductive and general health purposes. But the way these apps collect and use data involves risk.

Nearly two years after the devastating August 2023 wildfires, new findings from the largest post-disaster health study in Hawaiʻi's history—led by the University of Hawaiʻi—paint a complex picture: steady progress in some areas of recovery, but continued health and housing challenges, particularly for children and vulnerable groups.

If the idea of going to the gym makes you moan and groan, you're not alone.

A new study has gained international attention for providing clear, research-based answers to a question dentists worldwide have debated for years: Should an open or closed surgical technique be used when children have canine teeth that fail to erupt in the upper jaw? Some of the study's results have now been published in the American Journal of Orthodontics and Dentofacial Orthopedics and were highlighted by the British orthodontic blogger Kevin O'Brien.

New research reveals how seasonal diseases impact our willingness to follow health measures. People are less likely to follow protective measures when infection levels drop, leading to seasonal surges in disease.

An Aston University optometrist, Professor James Wolffsohn, has determined an optimum blinking exercise routine for people suffering with dry eye disease, and has developed a new app, MyDryEye, to help them complete the routine to ease their symptoms. The research is published in the journal Contact Lens and Anterior Eye.

A Peter Mac-initiated clinical trial suggests a way to dramatically improve outcomes in patients with high-risk forms of large B-cell lymphoma, who otherwise have a 50% chance of cure from conventional therapy.

For the first time, researchers have studied what happens in the brains of people who have migraines when they haven't slept enough: The mechanisms in the brain that should reduce pain don't work as well.

A multidisciplinary team has taken a step forward in the field of precision medicine with the publication of a study that highlights the value of integrating multiple layers of biological information—genomic, metabolomic, and lipoproteomic—to identify individuals with underlying molecular risk despite being apparently healthy and without relevant clinical manifestations.

Synthetic chemicals and plastics are useful and indispensable in our lives. On the other hand, the world is grappling with plastic pollution—clogging oceans, threatening wildlife, and leaching into ecosystems. While eco-friendly alternatives are on the way, researchers have been trying to identify the various effects of the synthetic plastics present within the ecosystem.

An innovative community-based mentoring scheme for pregnant adolescent girls in Sierra Leone has been found to save lives, while also helping girls return to education.

The ancient wandering womb theory suggested that many ailments in women were caused by the uterus becoming dislodged and roaming the body in search of moisture.

Self-esteem scores more than doubled within one year of weight-loss surgery, according to a new study presented today at the American Society for Metabolic and Bariatric Surgery (ASMBS) 2025 Annual Scientific Meeting.

As summer temperatures rise, a Houston emergency room doctor is sharing important tips to help folks stay safe while outdoors.

Dozens of HIV experts at the Centers for Disease Control and Prevention received emails earlier in June revoking notices they received 10 weeks ago that laid them off. Damage to their projects may be permanent, however, and ongoing restrictions on their research will harm lives, multiple HIV scientists at the CDC told KFF Health News on condition of anonymity because of fears of retaliation.

Boston Children's Hospital scientists have unveiled a five-day approach to generate functional vascular organoids capable of supporting blood flow and in vivo engraftment.

A cancer patient's sense of agency as an active individual is not fixed, according to a study from the University of Eastern Finland. The study, published in Qualitative Health Research, explored how a cancer patient's experience of agency, i.e., their sense of being able to influence their life, changes during diagnosis and treatment, as well as in response to wider societal crises. Conducted as a co-research project, the study followed the long-term experience of a single patient.