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Seven-year study reveals rheumatoid arthritis begins long before symptoms, opening door to prevention 

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  • 2025-09-25 01:00 event
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Seven-year study reveals rheumatoid arthritis begins long before symptoms, opening door to prevention 
Scientists have discovered that rheumatoid arthritis (RA) doesn't start when the pain begins. It silently starts years earlier. RA is a debilitating autoimmune disease that causes painful joint inflammation and damage. The new research reveals that people at risk for RA experience dramatic immune system changes long before they feel symptoms. During this early phase, their bodies fight an autoimmune battle invisibly.

15. Gut microbiota and immune response linked to breast cancer risk

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Breast cancer remains one of the most common cancers worldwide and a leading cause of cancer-related deaths among women. Despite advances in screening and treatment, advanced stages of the disease remain difficult to manage, and researchers continue to search for better ways to understand and reduce risk.

16. Report explores perspectives on living with dementia

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To experience or even contemplate dementia raises some of the most profound questions: What does it mean to be a person? How does someone find meaning in life while facing progressive neurological deterioration? What do health care providers, or residents of a neighborhood, or citizens of aging societies, owe to people living with dementia, and why? And how do shared ideas and values – narratives – that circulate within societies and groups shape the experience of living with dementia, for better or worse?

17. Reducing cannabis-related risks becomes focus of new app

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Scientists at Université de Montréal's affiliated hospital research center (CRCHUM) are testing out a mobile application to help young adults who have a first episode of psychosis to support safer cannabis consumption.

18. Racial discrimination linked to higher risk of developing psychotic symptoms

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Being racially or ethnically discriminated against may increase the risk of later developing psychotic symptoms, finds a major review of international evidence led by University College London (UCL) researchers.

19. IQ appears to affect ability to listen in noisy settings

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You're in a bustling café with a friend. The din is making it hard to tune in to the conversation. The scenario might suggest you'd benefit from a hearing aid. On the other hand, new research suggests that speech-perception difficulty might relate to your cognitive ability.

20. Older adults can bounce back to thriving health, study finds

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A new Canadian study is offering a powerful message to older adults and those who care for them: it's never too late to bounce back. Researchers at the University of Toronto have found that nearly one in four older adults age 60 or older who reported poor well-being at the beginning of a national study—due to pain, health issues, low mood, or isolation—had regained optimal well-being within just three years.

21. Why do we remember some life moments—but not others?

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Some memories are easy to recall—lush with detail, fresh as the moment itself. Others are more tenuous, like faded sketches, and the most stubborn ones can refuse to resurface at all. Why do our brains enshrine some memories so indelibly, and let others slip away?

22. First-ever image of an open NMDA receptor reveals clues to how neurodegenerative disease occurs

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When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, know that even slight changes in their activity level can mean the difference between normal function and serious neurological disorders.

23. A coordinated dance between two proteins is essential for stronger brain connections

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Scientists from the Nencki Institute and the Max Planck Florida Institute for Neuroscience have revealed a key mechanism in how our brains change when we learn new information or form memories. A new study published in Science Advances reveals a molecular mechanism that allows brain cells to precisely strengthen specific connections—a process essential for learning, memory, and overall brain health.

24. Seven-year study reveals rheumatoid arthritis begins long before symptoms, opening door to prevention 

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Scientists have discovered that rheumatoid arthritis (RA) doesn't start when the pain begins. It silently starts years earlier. RA is a debilitating autoimmune disease that causes painful joint inflammation and damage. The new research reveals that people at risk for RA experience dramatic immune system changes long before they feel symptoms. During this early phase, their bodies fight an autoimmune battle invisibly.

25. ChatGPT-4o therapeutic chatbot may be as effective as journaling for relationship support

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One of the first randomized controlled trials assessing the effectiveness of a large language model (LLM) chatbot known as "Amanda" for relationship support shows that a single session of chatbot therapy can be as beneficial as evidence-based journaling in assisting with relationship conflict resolution.

26. Spirals in the umbilical cord help to keep babies cool before birth, new research finds

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The coiled structure of the umbilical cord—the vital link between a baby and its mother during pregnancy—plays an important role in helping to keep babies healthy in the womb, according to new research led by The University of Manchester.

27. Paracetamol, pregnancy and autism: What the science really shows

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US president Donald Trump has claimed that paracetamol (acetaminophen or Tylenol) use in pregnancy is linked to autism in children, urging pregnant women to avoid the painkiller. This announcement has sparked alarm, confusion and a flurry of responses from health experts worldwide. Trump's comments come in a long line of unsubstantiated claims about the causes of autism, with paracetamol now the latest target.

28. Neuroscience finds musicians feel pain differently from the rest of us

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It's well known that learning to play an instrument can offer benefits beyond just musical ability. Indeed, research shows it's a great activity for the brain—it can enhance our fine motor skills, language acquisition, speech, and memory—and it can even help to keep our brains younger.

29. Patient stem cells may offer new hope for end-stage kidney disease treatment

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More than 4 million people worldwide have end-stage kidney disease that requires hemodialysis, a treatment in which a machine filters waste from the blood. Hemodialysis is a precursor to kidney transplant. To prepare for it, patients typically undergo surgery to connect an artery and a vein in the arm, creating an arteriovenous fistula (AVF) that allows blood to flow through the vein for treatment. However, AVF fails about 60% of the time due to vein narrowing. This is a major barrier to effective treatment.

30. Enhanced CAR T cells emerge from genetic screening

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CAR T cells are patient-derived, genetically engineered immune cells. They are "living drugs" and constitute a milestone in modern medicine. Equipping T cells, a key cell type of the immune system, with a "chimeric antigen receptor" (CAR) enables them to specifically recognize and attack cancer cells.

31. Around one in three hospital infections involve antimicrobial resistance, study shows

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With an estimated 1.14 million deaths worldwide annually caused by bacteria becoming resistant to antibiotics, a University of Leicester-led study shows that in hospital settings antimicrobial resistance is common and independently associated with a higher risk of death.

32. Donor milk storage key to preemie gut health

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Odds are that when you go to the supermarket, you check each product you pick up for its "best by" date, ensuring that you have the freshest, healthiest food to bring home for you and your family. An MUSC study published in the Journal of Parenteral and Enteral Nutrition has found that those little best by dates for a particularly precious resource—donor human milk—have huge implications for the gastrointestinal health of very premature infants.

33. How human behavior, lockdowns and restrictions shaped COVID-19's spread

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University of Kansas researcher Folashade Agusto trained as an applied mathematician, though today she's an associate professor of ecology & evolutionary biology. She uses that mathematical training and computers to model infectious diseases. Her goal is "to identify ways in which we can mitigate the risk they pose to humans," she said. "But I also do models involving animals as needed—and in recent times, I've started looking at plants as well."

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