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Single-dose CAR-T therapy potentially curative in multiple myeloma

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  • 2025-06-07 20:50 event
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Single-dose CAR-T therapy potentially curative in multiple myeloma
A multi-institutional study led by the Icahn School of Medicine at Mount Sinai reports one-third of patients with relapsed or refractory multiple myeloma remained in remission for at least five years following a single infusion of the CAR-T cell therapy cilta-cel.

2.492. How to protect yourself from narcissists' weapon of choice—passive aggression

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Imagine asking a coworker to help you on a project, and although they agree, they suddenly "forget" whenever the deadline approaches. Or a friend saying "you look beautiful today, I barely recognized you," after you show them your new haircut.

2.493. Spit or swallow? What's the best way to deal with phlegm?

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In 1821, French physician René Laennec wrote, "A spitting pot I consider as an essential part of the bedroom apparatus." Laennec, who invented the stethoscope, spent his days gazing at his patients' phlegm. In the days before X-rays and blood tests, phlegm was considered a valuable diagnostic tool.

2.494. Surfers play crucial role in beach safety according to study

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A first-of-its-kind study by La Trobe University has shown the critical contribution surfers make to beach safety in Victoria.

2.495. Genetic mutation linked to iron deficiency in Crohn's disease patients

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A study led by biomedical scientists at the University of California, Riverside School of Medicine shows how a genetic mutation associated with Crohn's disease can worsen iron deficiency and anemia—one of the most common complications experienced by patients with inflammatory bowel disease, or IBD.

2.496. Knowledge-based TikTok videos help ease fears about gynecological checkups

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No longer just pet videos and pranks, short-form videos are utilized more and more to share health information. Doctors and researchers are taking to social media networks themselves to encourage regular screenings for disease.

2.497. New rules for cosmetic injectables aim to make the industry safer. Will they work?

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New guidelines to regulate Australia's booming cosmetic procedures industry have been called "tough" and "a crackdown" in media reports this week.

2.498. Resident-to-resident aggression is common in nursing homes. Here's how we can improve residents' safety

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The Coroners Court of Victoria is undertaking an inquest into the deaths of eight aged care residents across six facilities, over a nine-month period in 2021.

2.499. Better planning can reduce sickness absence among shift workers

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Jarno Turunen, senior specialist at the Finnish Institute of Occupational Health and M.Sc. (Econ), has investigated the effects of shift work characteristics on the sickness absence of shift workers in his doctoral dissertation at the Jyväskylä University School of Business and Economics, Finland.

2.500. Long-lasting HIV prevention shot headed toward approval

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FA new injection to prevent HIV is expected to be approved by the U.S. Food and Drug Administration (FDA) later this month.

2.501. Single-dose CAR-T therapy potentially curative in multiple myeloma

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A multi-institutional study led by the Icahn School of Medicine at Mount Sinai reports one-third of patients with relapsed or refractory multiple myeloma remained in remission for at least five years following a single infusion of the CAR-T cell therapy cilta-cel.

2.502. Women less likely to receive treatment for deadly heart condition

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Women, people from ethnic minority backgrounds, and those from the most deprived communities are less likely to receive treatment after a diagnosis of the heart valve disease aortic stenosis, according to research presented Tuesday at the British Cardiovascular Society conference in Manchester.

2.503. Measles outbreaks in Michigan and Pennsylvania end, while Texas logs just 4 new cases

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The U.S. logged 122 more cases of measles this week—but only four of them in Texas—while the outbreaks in Pennsylvania and Michigan have officially ended.

2.504. Nurses cite staffing shortages, language barriers, and profit focus as key care challenges

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A new Penn Nursing Center for Health Outcomes & Policy Research (CHOPR) study sheds light on the critical factors that help or hinder hospital nurses in providing quality care to socially disadvantaged populations. The findings, published in JAMA Network Open, offer vital insights to inform hospital strategies for advancing high-quality, equitable care.

2.505. New research links skin barrier dysfunction to pediatric eosinophilic esophagitis

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A groundbreaking study led by National Jewish Health researchers suggests that the skin may serve as a potential biomarker for a chronic allergic disease of the esophagus called eosinophilic esophagitis (EoE) in children. The results provide physicians a potential new, noninvasive avenue to diagnose EoE by using skin tape.

2.506. Food-oriented LLM tackles data challenges to advance nutritional applications

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Researchers from the Institute of Computing Technology of the Chinese Academy of Sciences, along with collaborators, have developed a food-oriented large language model (LLM)—FoodSky. The study is published in Patterns.

2.507. Can pediatric e-consults improve access to specialty care?

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There is a nationwide shortage of pediatric specialists, delaying care for many patients. In some cases, children wait weeks or even months for appointments. But now, in a study published in the journal Clinical Pediatrics, researchers at UC Davis Health show that e-consults—in which primary care pediatricians have direct access to specialists—improve care for young patients.

2.508. mRNA vaccines modified to include cytokine IL-12 enhance T cell response

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In the quest to design vaccines that better help the body's immune system fight disease, scientists are always looking for more tools for their arsenal.

2.509. Discovery of Gpr45 gene activity in brain cilia sheds light on genetic roots of overeating

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Using a tool called Automated Meiotic Mapping (AMM) that was developed at UT Southwestern Medical Center, a team of researchers has identified a gene that appears to be key to regulating food intake.

2.510. Provoking symptoms before brain stimulation shows promise for treating OCD and nicotine dependence

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A new study published in JAMA Psychiatry makes the case that symptom provocation may significantly improve the clinical effectiveness of repetitive transcranial magnetic stimulation (rTMS), a noninvasive brain stimulation method used to treat depression, obsessive-compulsive disorder (OCD) and nicotine dependence.

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