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Stem cells created from ALS patients point to potential new target for treatment

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  • 2025-08-05 16:00 event
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Stem cells created from ALS patients point to potential new target for treatment
Amyotrophic lateral sclerosis (ALS), known as Lou Gehrig's disease, is an incurable neurological disorder affecting motor neurons—nerve cells in the brain and spinal cord that control voluntary muscle movement and breathing.

658. FDA requires stronger safety labels for opioid medications

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The U.S. Food and Drug Administration announced it will now be requiring updated safety labels for all opioid pain medications to better highlight the risks of long-term use, including misuse, addiction, and overdose.

659. Treatment for obstructive sleep apnea lowers heart risk for some patients, increases risk for others

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Recent findings suggest that a personalized approach to recommending CPAP machines to patients with obstructive sleep apnea may decrease adverse cardiovascular events.

660. Eating earlier linked to long-term weight-loss success

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Complutense University of Madrid-led researchers report that eating earlier in the day blunts the weight gain ordinarily predicted by a high genetic score for obesity.

661. iPSC-based vaccines: A new hope for preventing and treating colorectal cancer

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A research team at National Taiwan University has developed a new stem cell-based vaccine that could help prevent and treat colorectal cancer.

662. Key protein Gfi1 found to regulate exhausted T cells in cancer and infection

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Killer immune cells destroy cancer cells and cells infected by virus. These CD8+ T cells are activated after detection of viral infection or growth of "non-self" tumor cells. However, in chronic viral infection and cancer, the killer cells often lapse into "exhausted" CD8+ T cells that no longer can stem disease.

663. Mailing at-home test kits boosts colorectal cancer screening in adults under 50

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In a new study aimed at identifying the best approach to promote colorectal cancer screening in adults aged 45 to 49, UCLA researchers found that simply mailing a stool-based test directly to people's homes was the most effective strategy for increasing screening rates.

664. Brain cells controlling stress switch on and off in hourly cycles

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University of Otago Ōtākou Whakaihu Waka-led research has found stress-controlling brain cells switch on and off in a steady rhythm about once every hour—even when nothing stressful is happening.

665. Metabolic signals in neurons determine whether axons degrade or resist neurodegeneration, study finds

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Unlike most cells in the human body, neurons—the functional cells of our nervous system—cannot typically replace themselves with healthy copies after being damaged.

666. Just rise: Study finds frequent standing may boost heart health after menopause

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The simple daily habit of standing up more often may impact heart health for postmenopausal women, according to a new study from the University of California San Diego. Researchers reported that women experiencing overweight or obesity who increased daily sit-to-stand movements saw measurable improvements in blood pressure.

667. Stem cells created from ALS patients point to potential new target for treatment

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Amyotrophic lateral sclerosis (ALS), known as Lou Gehrig's disease, is an incurable neurological disorder affecting motor neurons—nerve cells in the brain and spinal cord that control voluntary muscle movement and breathing.

668. Genes reveal why some older people suffer from frailty

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A new study has identified genetic variants linked to brain function, immune defense and metabolism that contribute to the development of frailty in older people. The study, published in Nature Aging by researchers from Karolinska Institutet, provides new biological insights into the onset of frailty.

669. Bacterial duo eliminates tumors without immune system help in new cancer therapy

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A joint research team led by Professor Eijiro Miyako of the Japan Advanced Institute of Science and Technology (JAIST), in collaboration with Daiichi Sankyo Co., Ltd. and University of Tsukuba, has developed an immune-independent bacterial cancer therapy using a novel microbial consortium called AUN.

670. Japan firm seeks approval for stem cell treatment for Parkinson's

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Japanese drugmaker Sumitomo Pharma said Tuesday it is seeking approval for a Parkinson's disease treatment that transplants stem cells into a patient's brain, following a successful clinical trial.

671. Resource-poor neighborhood conditions may increase gestational diabetes risk

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New research from the University of Arizona Mel and Enid Zuckerman College of Public Health shows that living in resource-poor neighborhoods may raise the risk of women developing diabetes during pregnancy, a condition with potential long-term effects on the health of both mother and child.

672. The world nearly beat polio. But fake records, an imperfect vaccine and missteps aided its comeback

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For the past decade, Sughra Ayaz has traveled door to door in southeastern Pakistan, pleading with parents to allow children to be vaccinated against polio as part of a global campaign to wipe out the paralytic disease. She hears their demands and fears. Some are practical—families need basics like food and water more than vaccines. Others are simply unfounded—the oral doses are meant to sterilize their kids.

673. Turning down the dial on inflammation to protect against lupus nephritis

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At the time when patients with lupus, or systemic lupus erythematosus (SLE), are diagnosed, approximately 15% to 30% will already have the inflammation-caused kidney disease lupus nephritis, which compromises kidney function and can lead to kidney failure. Between 30% and 50% of SLE patients will ultimately go on to develop lupus nephritis, and half of them will eventually develop end-stage renal disease.

674. Researchers debunk long-standing concern about flu treatment in children

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For decades, medical professionals debated whether a common antiviral medication used to treat flu in children caused neuropsychiatric events or if the infection itself was the culprit.

675. Vagus nerve stimulation paired with meditation increases self-compassion and mindfulness benefits

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Stimulating the vagus nerve with a device attached to the outer ear can help make compassion meditation training more effective at boosting people's capacity for self-kindness and mindfulness, finds a new study led by University College London (UCL) researchers.

676. New molecular technology targets tumors and simultaneously silences two 'undruggable' cancer genes

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University of North Carolina Lineberger Comprehensive Cancer Center researchers have developed a "two-in-one" molecule that can simultaneously turn off two notoriously difficult-to-target cancer-related genes, KRAS and MYC, as well as directly deliver drugs to tumors that express these genes. This advance holds special promise for treating cancers that have been historically challenging to treat.

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