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Malaria remains one of the leading causes of death among children in sub-Saharan Africa, claiming more than 600,000 lives each year worldwide with limited efficacy in currently available treatments and vaccines. Now a new early-stage clinical trial found that a novel monoclonal antibody provided dose-dependent full protection against the malaria parasite with minimal side effects.
Patients with estrogen-receptor-positive HER-2-negative advanced breast cancer showed significantly improved progression-free survival when treated with an oral combination regimen that includes giredestrant, a novel, next-generation selective estrogen receptor degrader and full antagonist, compared to a standard combination approach. These findings, from the phase 3 evERA Breast Cancer study, are presented today by Dr. Erica Mayer of Dana-Farber Cancer Institute at the annual meeting of the European Society for Medical Oncology (ESMO) in Berlin, Germany.
A new 3D human brain tissue platform developed by MIT researchers is the first to integrate all major brain cell types, including neurons, glial cells and the vasculature into a single culture. Grown from individual donors' induced pluripotent stem cells, these models—dubbed Multicellular Integrated Brains (miBrains)—replicate key features and functions of human brain tissue, are readily customizable through gene editing, and can be produced in quantities that support large-scale research.
A review in Clinical Epigenetics synthesizes growing evidence that paternal lifestyle and environmental exposures such as diet, obesity, smoking, endocrine-disrupting chemicals, and stress alter sperm epigenetic marks (DNA methylation, histone retention, and small non-coding RNAs). These changes can influence sperm quality and fertilizing ability, early embryo development, assisted reproduction outcomes, and long-term health risks in offspring.
When we are engaged in a task, our brain's auditory system changes how it works. One of the main auditory centers of the brain, the auditory cortex, is filled with neural activity that is not sound-driven—rather, this activity times the task, each neuron ticking at a different moment during task performance.
Air pollution is one of the world's leading health risks, contributing to nearly one in eight deaths globally. A new study published in Science Advances by the Euro-Mediterranean Center on Climate Change (CMCC) shows that stringent climate policies designed to avoid temporarily exceeding 1.5°C warming could prevent hundreds of thousands of premature deaths while avoiding trillions of dollars in economic damages.
When immune cells strike, precision is everything. New research reveals how natural killer and T cells orchestrate the release of toxic granules—microscopic packages that destroy virus-infected or cancerous cells.
Late nights, early risings and broken sleep schedules are hallmarks of youth, but those sleepless nights may leave marks deeper than dark circles under the eyes.
Researchers from Rutgers Health and other institutions have discovered why a powerful leukemia drug eventually fails in most patients—and found a potential way to overcome that resistance.
As artificial intelligence (AI) use continues to grow in nearly every industry, it is important to establish guardrails to make sure the technology is used ethically and responsibly. This is especially true in the field of medicine, where errors can be a matter of life and death and patient information must be protected.
Florida wildlife officials have confirmed the state's second case of a deadly and highly contagious infection known as "zombie deer disease" in a wild deer.
The accuracy of child car seat installation and restraint usage following education with a remotely located technician is noninferior to that with an on-site technician, according to a study published online Oct. 13 in Pediatrics.
Receiving two doses of inactivated influenza vaccine (IIV) in the first year of influenza vaccination is associated with improved protection for children younger than 3 years versus one dose, according to a study published online Oct. 3 in JAMA Network Open.
Michael Gotthardt at the Max Delbrück Center and collaborators are developing a drug to treat a common type of heart failure characterized by impaired cardiac filling. In a recent study, his group and a US team showed the therapy improves cardiac function in a mouse model of the disease.
Two types of industrially processed hard fats, widely used in everyday foods such as bakery products, margarines and spreads, are unlikely to affect heart health when consumed in levels achievable in most people's diets.
A new analysis reveals how deeply the U.S. drug supply chain depends on China, and experts warn that a trade war could leave American patients at risk.
Scientists at University College London have engineered a rare type of immune cell to kill slow-growing bowel cancer cells that are resistant to current therapies, a breakthrough that could lead to new treatments in the future.
For people with medical conditions, stigma is a real problem they must worry about on top of their health. Stereotypes about health conditions often cause discrimination even by health care providers, as many may assume those affected don't take care of their health, when in reality they likely have no control over their condition.
Researchers led by Masako Tamaki at the RIKEN Center for Brain Science in Japan report a link between deep sleep and cerebrospinal fluid, the clear liquid that surrounds and supports the brain and spinal cord. Published in Proceedings of the National Academy of Sciences, the study demonstrates how changes in cerebrospinal fluid signals during sleep—as measured by MRI—are time-locked to slow brain waves and other neural events.