Study finds blocking minor splicing curbs tumor growth in multiple cancer types

Researchers at Nagoya University in Japan have developed a lipid nanoparticle that delivers mRNA to cells five times more effectively. By attaching a sulfur-containing ring structure—a cyclic disulfide—to lipid molecules, they found that significantly more mRNA can escape from cell components that normally destroy genetic material. When tested as a cancer vaccine in mice, the new delivery system stopped tumor growth.

Until now, the sensory neurons inside the tooth were primarily thought to send pain signals to the brain, but a new study shows those neurons are multitaskers that also trigger a jaw-opening reflex that almost instantaneously prevents damage and further injury to teeth.

A new research article published in the Journal of Participatory Medicine unveils how successive waves of digital technology innovation have empowered patients, fostering a more collaborative and responsive health care system. The paper, titled "From Internet to Artificial Intelligence (Al) Bots: Symbiotic Evolutions of Digital Technologies and e-Patients," explores the symbiotic evolution of digital health tools and the increasingly engaged e-patient.

A multi-institution team of investigators report that adults who later develop cardiovascular disease show declining physical activity levels beginning roughly 12 years before their event, with the gap versus their healthy peers persisting long afterward.

A world-first estimate shows assisted reproductive technology (ART) is now part of everyday life for millions of families across the globe, with one ART-conceived baby born every 35 seconds.

Targeted and holistic health and well-being interventions are critical to addressing loneliness in retirement villages, researchers from Bolton Clarke Research Institute and Monash University have found.

There is broad consensus that the overall body of evidence shows lowering LDL (low-density lipoprotein) cholesterol provides both statistically significant and clinically meaningful benefits in treating and preventing cardiovascular disease. Often referred to as the "bad" cholesterol, elevated levels of LDL can clog arteries and significantly increase the risk of heart attacks and strokes.

Prostate cancer is one of the most common cancers in the world. While many prostate cancers grow slowly and remain localized, other types are aggressive and spread quickly. That's why Dr. Carlos Vargas, a Mayo Clinic radiation oncologist, encourages regular screening. He says the goal of screening is to detect prostate cancer early, when it's still confined to the prostate gland and has the best chance for successful treatment.

A research team from National Taiwan University, Academia Sinica, and National Taiwan University Hospital has uncovered a critical connection between a unique RNA molecule and human aging, including early-stage Alzheimer's disease. Their findings, recently published in Nucleic Acids Research, spotlight TERRA—a long non-coding RNA transcribed from the ends of chromosomes—as a potential biomarker for age-related and neurodegenerative conditions.

Consider the delicate web of fat in a Wagyu steak. The "marbling" that makes carnivore connoisseurs swoon is a visual heuristic for quality flavor.

Johns Hopkins University researchers have grown a novel whole-brain organoid, complete with neural tissues and rudimentary blood vessels—an advance that could usher in a new era of research into neuropsychiatric disorders such as autism.

Researchers have discovered a way to make the immune system's T cells significantly more effective at fighting cancer. By blocking a protein called Ant2, they were able to reprogram how these cells consume and generate energy—essentially rewiring their internal power supply.

Swimming pools can have a powerful pull on little children―even when it's not swimming time. Those glistening turquoise-blue ripples may look especially inviting to an active toddler or an overly confident preschooler.

Republicans defended the GOP megabill's Medicaid changes as targeting a group of people they believe shouldn't qualify: people who can work but instead choose to stay home and chill.

While West Nile remains the greatest mosquito-borne threat in Pennsylvania, state officials are monitoring another virus that has begun popping up in mosquito populations.

For the millions of Texans who get their health insurance on the marketplace, coverage is likely to get a lot pricier next year.

Sunburns are common—about a third of Americans get at least one each year—and are, most of the time, mild or treatable. But some burns are more severe than others.

In an update to the guidelines for managing atopic dermatitis in adults, four new treatment recommendations are presented. The focused update was published online in the Journal of the American Academy of Dermatology.