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Study highlights protein tyrosine phosphatase PTP1B as key driver in heart disease linked to obesity, high-fat diet

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  • 2025-07-23 01:00 event
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Study highlights protein tyrosine phosphatase PTP1B as key driver in heart disease linked to obesity, high-fat diet
A groundbreaking study led by researchers at the Masonic Medical Research Institute (MMRI) has identified a promising molecular target to protect the heart against damage caused by a high-fat diet and obesity.

1.430. Study identifies social steps to mitigate mental illness

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Mental illnesses are thought to be caused by both biological and environmental factors in complex interaction. Among the environmental contributors are a wide range of social, economic, and demographic factors known as "social determinants."

1.431. Novel analysis identifies differences between benign and cancerous breast calcifications

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Benign and cancerous calcium phosphate deposits that may look identical on a mammogram have distinct differences in their structures and formation processes, according to researchers at the University of Illinois Urbana-Champaign and collaborators at the Mayo Clinic and the University of Texas at Austin.

1.432. Unique immune cell linked to aggressive leukemia may lead to improved treatment outcomes

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A new study by Indiana University School of Medicine researchers has revealed a breakthrough in the fight against acute myeloid leukemia, one of the most aggressive and fatal blood cancers in adults. The discovery of a previously unrecognized immune cell could lead to new therapies that are less treatment-resistant than current options for patients—meaning higher survival rates for people with blood cancers.

1.433. Tailored deep brain stimulation improves walking in Parkinson's disease

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For patients with Parkinson's disease, changes in their ability to walk can be dramatic. "Parkinson's gait," as it is often called, can include changes in step length and asymmetry between legs. This gait dysfunction reduces a person's mobility, increases fall risk, and significantly impacts a patient's quality of life.

1.434. Indicators of neuropathic ocular pain identified after LASIK

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In a study published in the August issue of the American Journal of Ophthalmology, diagnostic indicators are identified for confirming chronic neuropathic ocular pain (NOP) for patients experiencing chronic dry eye (DE) after laser-assisted in situ keratomileusis (LASIK).

1.435. Fire safety tips: Prevent burns around campfires

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Sitting around a campfire can be a beloved part of time with family and friends. But for families with young children, it's important to be aware of the risk of burns and know how to prevent and respond to such injuries.

1.436. Subclinical synovitis risk higher in psoriasis without musculoskeletal involvement

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Subclinical synovitis is significantly more common among patients with psoriasis without musculoskeletal involvement than healthy controls, according to a review published online July 16 in JAMA Dermatology.

1.437. Recalled: More than 67,000 cases of deodorant sold at Dollar Tree, Walmart, and Amazon

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TUESDAY, July 22, 2025 (HealthDay News) — More than 67,000 cases of Power Stick deodorant have been recalled due to an undisclosed manufacturing issue.

1.438. There is no known cure for ALS, but medical tourism exploits desperation for profit

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Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder of unknown cause, in which motor nerve cells of the brain and spinal cord that transmit signals to muscles progressively degenerate. This weakens limbs and affects speech, swallowing and ultimately the ability to breathe, resulting in death, typically within just a few years.

1.439. Study highlights protein tyrosine phosphatase PTP1B as key driver in heart disease linked to obesity, high-fat diet

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A groundbreaking study led by researchers at the Masonic Medical Research Institute (MMRI) has identified a promising molecular target to protect the heart against damage caused by a high-fat diet and obesity.

1.440. Body clock keeps 24-hour rhythm by distorting gene activity in the heat

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Researchers led by Gen Kurosawa at the RIKEN Center for Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS) in Japan have used theoretical physics to discover how our biological clock maintains a consistent 24-hour cycle—even as temperatures change.

1.441. Digital model based on noninvasive factors shows accuracy for identifying inflammatory bowel disease in children

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A model based on noninvasive tests shows high accuracy as a digital tool for the rapid identification of children with inflammatory bowel disease (IBD), according to a study published online July 12 in the Journal of Inflammation Research.

1.442. New 3D tissue model may speed better therapies for fibrosis

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For the 300,000 Americans living with the immune disease scleroderma, better treatments can't come soon enough. The rare and sometimes fatal illness stiffens and scars tissue in organs like the lungs, liver, and kidneys, as well as skin. It may quietly affect one patch of skin for years or rapidly turn life-threatening, depending on where and how severely it strikes.

1.443. A breath test could help us detect blood cancers

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Molecules exhaled in the breath may help detect blood cancer, according to new research from Queen Mary University of London. The findings could enable the development of a blood cancer breathalyzer, providing a rapid, low-cost way to detect disease. This tool may be particularly useful for areas with limited access to specialist equipment or expertise.

1.444. Cancer-fighting radioisotope being optimized for therapeutic use

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A promising breakthrough in cancer treatment is taking shape at the University of Missouri Research Reactor (MURR), where scientists are developing a powerful radioisotope that could one day precisely target and destroy cancer cells.

1.445. Study highlights potentially dangerous e-cigarette modifications by youth, adults

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A new study led by Georgia State University researchers has found that more than 84% of youth and young adults who use e-cigarettes have modified their device, often in potentially dangerous ways.

1.446. Misfolded proteins accumulate in mitochondria of patients with type 2 diabetes, study finds

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Aging-related diseases, including cancer, cardiovascular disorders and type 2 diabetes, are associated with defects in protein synthesis and folding.

1.447. WHO sounds alarm on risk of chikungunya epidemic

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The World Health Organization warned on Tuesday a major chikungunya virus epidemic risks sweeping around the globe, calling for urgent action to prevent it.

1.448. Lymphoid-derived dendritic cells found to shape immune suppression and allergy responses

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Lymphoid-derived conventional dendritic cells (L-cDCs) may play a unique function associated with immune suppression and allergy induction, as reported by researchers from Japan. Long thought to arise only from myeloid lineages, cDCs were found to also originate from lymphoid progenitors. Using fluorescent reporter mice, the team tracked L-cDCs throughout the body, revealing their abundance in barrier tissues like skin and lungs and their distinct genetic signatures and functions.

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