Study identifies factors affecting survival of patients with metastatic breast cancer

A new study co-led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center has found that women with early-stage cervical cancer who received radiation plus chemotherapy reported a greater short-term decline in quality of life than those who received radiation alone.

Neuroblastoma is a type of cancer that affects the sympathetic nervous system in young children and is often difficult to treat, especially when the tumor cells carry multiple copies of the MYCN gene.

Decision making ability, memory, response times and dexterity all saw a significant drop in cold temperatures, according to University of Chichester research on firefighter search and rescue performance.

A prospective study conducted at Avicenna University Hospital (Cadi Ayyad University) suggests that the plethysmographic perfusion index (PPI), a noninvasive parameter derived from pulse oximetry, can help identify fluid responsiveness in critically ill patients with acute circulatory failure. The research is published in the Journal of Intensive Medicine.

Colorectal cancer is one of the most common tumors among people over the age of 50. Although it is known to develop from small lesions or polyps, its exact causes are unknown—only a few risk factors are known—and it is usually treated with surgery, chemotherapy and radiotherapy, or biological therapies. Now, a study by the University of Barcelona reveals that the combination of palbociclib and telaglenastat, two drugs with complementary actions, could help improve the clinical treatment of this type of cancer, the third most common worldwide.

Researchers at Wake Forest University School of Medicine have developed a battery-free wearable patch that could help detect skin cancer earlier and more accurately, potentially saving lives by making screening more accessible and less invasive. The study was recently published in npj Biomedical Innovations.

Most people over 50 were already adults when the Americans with Disabilities Act took effect in 1992 and transformed the rights of people with physical and mental conditions.

Researchers at the Francis Crick Institute have found that hunger can make virgin female mice aggressive towards pups, but only in certain hormonal states. These mice would usually ignore other females' pups or show parent-like caring behavior.

A genomic test co-developed by Mayo Clinic and SkylineDx can identify whether people with melanoma are at low or high risk for cancer in their lymph nodes—a finding that could guide treatment decisions and help many people avoid lymph node biopsy surgery. The study results are published in JAMA Surgery.

The price tag of health insurance from employers keeps getting bigger across the U.S., and the increases this year are fueling concerns over medical spending across all health insurance markets.

Cellular changes that appear during melanoma and lead to treatment resistance can be reversed with drugs—potentially opening the door to new or more effective treatments for the deadly disease, according to new Cornell research.

With ads everywhere for pro- or pre-biotic foods and supplements, most people are familiar with the gut microbiome—the trillions of bacteria, fungi, and viruses that colonize our digestive tract—and the idea that keeping our gut microbiome healthy improves our overall health. But other areas of our bodies harbor their own unique microbiomes as well, and researchers are now starting to explore the role these microbial ecosystems play in health and disease.

A comprehensive meta-analysis in depression and mortality, led by the Department of Psychiatry at the School of Clinical Medicine, LKS Faculty of Medicine at the University of Hong Kong (HKUMed), has found that people with depression have twice the risk of death than those without depression, and a nearly 10-fold increased risk of suicide. However, timely and effective treatment can significantly reduce these risks and improve survival rates.

The number of people receiving treatment for cancer has risen dramatically in the last decade in many African countries. For example, 10 years ago in Ethiopia and Kenya, cancer care was available to only a few thousand patients per year in a few hospitals. Today, over 75,000 people receive cancer treatment each year in each of these countries.

Lung adenocarcinoma (LUAD) is the most common form of lung cancer, accounting for nearly half of cases. Many patients are diagnosed at advanced stages, and five-year survival remains below 20%.

About 50% of menopausal women experience genitourinary syndrome of menopause (GSM) that involves changes to the genitals, including the vagina, urethra and bladder. When estrogen levels drop during menopause, it can cause the GSM symptoms of vaginal dryness, itching, burning, frequent urinary tract infections and pain during sex. Replenishing the hormone through vaginal estrogen is an effective GSM treatment. But many breast cancer survivors either can't or don't want to use estrogen.

The number of people living with dementia worldwide was estimated at 57 million in 2021 with nearly 10 million new cases recorded each year. In the U.S., dementia impacts more than 6 million lives, and the number of new cases is expected to double over the next few decades, according to a 2025 study. Despite advancements in the field, a full understanding of disease-causing mechanisms is still lacking.

Elironrasib led to meaningful and durable responses in patients with metastatic KRAS G12C-mutated non-small cell lung cancer (NSCLC), including after prior treatment with KRAS G12C inhibitors and in the presence of features linked to KRAS inhibitor resistance, according to data from a phase I trial presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held October 22-26.