Supercharged vaccine could offer strong protection with just one dose

Justin Taylor, M.D., a physician-scientist at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, has released a preclinical study highlighting a potential new way to treat colorectal cancer. The findings appear in Cancer Research.

Researchers have found a promising new method for gene therapy. They successfully restarted inactive genes by bringing them closer to genetic switches on the DNA called enhancers. The intermediate piece of DNA was cut out using CRISPR-Cas9 technology.

An international group of psychiatrists, patient associations, and pharmaceutical companies has unveiled plans to systematically include objective biological tests in the diagnosis of psychiatric conditions. This Precision Psychiatry Roadmap, which may radically change the practice of psychiatry, is published in the journal Molecular Psychiatry.

Heading a soccer ball alters the brain, new research spearheaded by the University of Sydney has found, despite having no immediate impact on cognition.

Higher levels of well-being may help reduce the risk of memory loss in middle age, suggests new research, which tracked more than 10,000 over 50-year-olds across a 16-year span.

The anti-aging drug rapamycin has the same life-extending effect as eating less, according to new research from the University of East Anglia and University of Glasgow.

Intermittent fasting diets appear to have similar benefits to traditional calorie-restricted diets for weight loss, suggests an analysis of trial evidence published by The BMJ.

Your T cells work hard to fight disease. Unfortunately, "friendly fire" from T cells can sometimes harm the body's healthy tissues.

A more effective vaccine technology may be on the horizon. In a new study in mice, researchers from the University of Copenhagen demonstrate that a simple addition to mRNA vaccines can significantly enhance their effectiveness. The innovation could become a powerful tool in the next pandemic. The next step is human trials.

Persistent sadness, fatigue, changes in sleep and appetite, or loss of interest are common symptoms in mothers suffering from perinatal depression. How do these symptoms evolve? A pioneering study followed the paths of mothers with this condition. It concluded that high sensitivity to internal and external stimuli can increase the risk of depression, while partner support during pregnancy has a protective effect.

A research team led by Prof. Li Hai from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences has become the first to systematically explore how large language models (LLMs) can assist in predicting liver cancer treatment responses—offering a new path toward AI-powered precision medicine.

Researchers in Taiwan and Belgium developed a lab-based diagnostic workflow that could help doctors predict the severity of a rare childhood brain disorder called FOXG1 syndrome (a rare neurodevelopmental disorder, like Rett syndrome). The findings could support earlier and more personalized interventions for children with FOXG1 gene mutations.

A study published in the Harm Reduction Journal identifies critical factors and strategies for expanding low-barrier wound care services for people who use drugs (PWUD).

Regulator-approved AI models used in eye care vary widely in providing evidence for clinical performance and lack transparency about training data, including details of gender, age and ethnicity, according to a new review led by researchers at UCL (University College London) and Moorfields Eye Hospital.

A team of scientists at the University of California, Riverside, explains in a paper published in PLOS Pathogens how a microscopic parasite, Toxoplasma gondii, can significantly disrupt brain function, even when it infects only a small number of neurons. The team found that the parasite interferes with essential communication between brain cells—research that can offer new ways to detect and treat chronic brain infections.

Researchers have demonstrated a specific type of genetic variation in obsessive-compulsive disorder (OCD) for the first time using advanced DNA sequencing technology. The findings support previous studies by the same group and help build a more complete picture of how genetics contributes to and influences the development of the disorder. They also pave the way for future research into earlier diagnosis and targeted treatments.

The US Food and Drug Administration on Wednesday approved Gilead Sciences' twice-yearly injection to prevent HIV, a move the company hailed as a major breakthrough in the fight against the sexually transmitted virus.

The difference between the brain's predicted age and actual chronological age, called a brain age gap, may influence the relationship between cognitive impairment risk factors, like high blood pressure and diabetes, and a person's cognitive performance, also known as thinking and memory skills, according to a study published in Neurology.