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A research team from the University Hospital Bonn (UKB), the University of Bonn, and the Medical Center—University of Freiburg has gained new insights into the brain processes involved in encoding and retrieving new memory content. The study is based on measurements of individual nerve cells in people with epilepsy and shows how they follow an internal rhythm. The work has now been published in the journal Nature Communications.
Mitochondria, the tiny organelles without which our bodies would be deprived of energy, are gradually revealing their mysteries. In a study published in Nature Neuroscience, researchers from Inserm and the University of Bordeaux at the NeuroCentre Magendie, in collaboration with researchers from the Université de Moncton in Canada, have for the first time succeeded in establishing a causal link between mitochondrial dysfunction and the cognitive symptoms associated with neurodegenerative diseases.
For more than 30 years, scientists have studied how the myogenic determination gene number 1 (MYOD) protein binds DNA to modify the gene expression of muscle stem cells. Similar to the instant kung fu education Keanu Reeves downloaded in "The Matrix," MYOD plugs into muscle stem cell DNA and reprograms the cells to build muscle.
Targeting cellular structures called nuclear speckles could be a completely new approach for treating proteinopathies—diseases driven by abnormal accumulation of misfolded proteins—such as Alzheimer's, Parkinson's and prion diseases, according to new research published in Nature Communications and led by the University of Pittsburgh.
A new study from the Gray Faculty of Medical and Health Sciences at Tel Aviv University may mark a breakthrough in the treatment of Eosinophilic Esophagitis (EoE)—a chronic inflammatory disease of the esophagus caused by food allergies. EoE leads to difficulty swallowing, chest and abdominal pain, and even growth delays in children. Its prevalence has been steadily increasing over the past decade in Israel and the Western world.
Parents of children diagnosed with type 1 diabetes suffer an income drop in the years following the diagnosis. The impact is more pronounced in mothers, especially mothers of children diagnosed in preschool years. These findings from a study led by researchers at Uppsala University, Sweden, have now been published in Diabetologia.
Creatine supplementation is booming among those seeking greater muscle size and performance.
A researcher at The University of Texas at Arlington is helping a leading national cancer center explore how wearable devices could help childhood cancer survivors avoid long-term health complications such as diabetes and heart disease.
University of Jaén investigators report significant reductions in anxiety and increased life satisfaction in adults through laughter therapy across 33 clinical trials.
The U.S. Food and Drug Administration (FDA)'s top vaccine regulator is returning to his post less than two weeks after the White House had him ousted.
The R21/Matrix-M malaria vaccine generates nearly identical antibodies as those following a natural infection, helping explain why the vaccine confers such strong protection against the earliest life stage of malaria parasites, according to research published in the Journal of Experimental Medicine.
A new study by researchers at Unity Health, Sunnybrook Health Sciences Center and the University of Toronto has found that patients with a diabetes-related eye condition who are male, Black or Hispanic, or live farther from a treatment center are more likely to miss follow-up appointments, putting them at greater risk of vision loss.
Researchers at Boston University Chobanian & Avedisian School of Medicine have built an artificial intelligence (AI) tool that can accurately predict key signs of Alzheimer's disease—such as the presence of sticky proteins called amyloid beta and tau—using common and less expensive tests like brain scans, memory checks and health records. The findings appear online in the journal Nature Communications.
Oxytocin promotes social behaviors and helps maintain relationships. But clinical trials in patients with autism show variability in how consistently oxytocin improves these behaviors.
A cancer drug could enhance how patients respond to chemotherapy even in treatment-resistant tumors. The drug works by disarming a key defense mechanism that tumors use to protect themselves from treatment. In preclinical models, it has already shown promise in making chemotherapy-resistant cancers more responsive to therapy.
The search for new ways to treat malaria—a disease that kills some 600,000 people a year, most of them children in Sub-Saharan Africa—may have just gotten a boost.
Sensitive teeth need tough toothpaste, but technology can also help. Researchers at the Indian Institute of Science (IISc) in collaboration with deep-tech startup Theranautilus have now engineered CalBots—magnetic nanobots that can penetrate deep into dentinal tubules, which are tiny tunnels in teeth that lead to nerve endings. These CalBots can then form durable seals for worn enamel, offering lasting relief from sensitivity in just one application. The study is published in Advanced Science .
Yale University School of Medicine reports that cysteinyl leukotrienes released by intestinal mast cells are essential for anaphylaxis after food ingestion in mice, while responses to intravenous allergen challenge proceed without that requirement.
Treatment with interferon or with glatiramer acetate? This question arises for many patients who receive a diagnosis of multiple sclerosis (MS) for the first time. Until now, the choice between the two could practically be made at random: both preparations are considered established basic therapies, both have relatively low side effects and both are relatively well tolerated. And, as with all immunomodulatory therapies, both do not help all people equally well. However, thanks to a study led by the University of Münster, there is now a clear criterion for choosing the medication.