A less invasive, more effective method to analyze immunotherapy efficacy

For patients with early-stage cervical cancer, sentinel lymph node biopsy alone is noninferior to lymphadenectomy with respect to disease-free survival, according to a study published online Oct. 15 in the New England Journal of Medicine.

Teenagers who don't get enough sleep on school nights or have interrupted sleep are at greater risk of suicide, new research from the University of Warwick has found.

Ewing sarcoma is one of the most common bone cancers seen in children, and if it spreads, it can be deadly. One study found that under a quarter of children with multi-metastatic Ewing sarcoma survived five years after their diagnosis.

For a while, the "hot girls have stomach problems" trend on social media has been a way for women to destigmatize irritable bowel syndrome (IBS).

Anti-obesity medication semaglutide may help to prevent heart attacks and other major cardiac events regardless of how much weight people lose while taking the drug, according to a new study led by a UCL researcher.

Restricted sugar intake during early life is linked to lower risks of several heart conditions in adulthood, including heart attack, heart failure, and stroke, finds a study published by The BMJ using data from the end of UK sugar rationing in 1953.

One in five women with breast or cervical cancer in low- and middle-income countries (LMICs) are diagnosed at an early stage, compared with more than one in three in high-income countries (HICs), new research suggests. For ovarian cancer, the proportion of women diagnosed with early-stage disease was generally lower than 20% (one in five) worldwide, although the situation remains slightly worse for women in LMICs.

For patients with inflammatory bowel disease (IBD), alterations in gut microbiota are associated with health-related quality of life (HRQoL) outcomes, according to a study published online Sept. 29 in The American Journal of Gastroenterology.

A new approach to PET imaging offers a promising way for physicians to promptly identify patients who are at risk for poor functional recovery after a heart attack, according to new research published in The Journal of Nuclear Medicine.

By analyzing the tumor environment of diffuse large B-cell lymphoma (DLBCL), researchers from The University of Texas MD Anderson Cancer Center have identified seven distinct cellular microenvironments, providing a framework to develop therapies that will engage a patient's immune system to attack cancer cells. Each microenvironment showed a different mix of cells and its own pattern of communication between tumor B-cells and immune cells.

A study conducted by researchers at the Center for Redox Processes in Biomedicine (Redoxoma) has shown that ATP-sensitive mitochondrial potassium channels (MitoKATP) are involved in both the development of brown fat cells and the activation of mitochondrial uncoupling in these cells, a process that dissipates energy in the form of heat.

An international collaborative study has identified the E2F2 protein as a potential new therapeutic target to prevent metabolic fatty liver disease from progressing toward more serious conditions, such as cirrhosis or liver cancer.

Adults with gum disease may be more likely to have signs of damage to the brain's white matter, called white matter hyperintensities, than people without gum disease, according to a study published in Neurology Open Access.

Many surgeons admit that medical robots can now operate with greater precision than human specialists. However, the complex preparation required for robotic surgery still takes far too long. But a new robotic assistant for eye surgery for age-related macular degeneration (AMD) developed by Prof. Mohammad Ali Nasseri from the Technical University of Munich (TUM) is ready to go in just under five minutes.

Today's GPS smartwatches and other wearable devices give millions of runners reams of data about their pace, location, heart rate and more. But one thing your Garmin can't measure is plain old physics: How much force is being generated when your foot hits the ground and takes off again.

Whether we are writing an email, rushing for a bus, or humming a tune, every thought, feeling, and action relies on communication between our roughly 100 billion nerve cells. This exchange of information happens at synapses, where messenger substances are passed from one cell to another.

Scientists have made significant progress in developing cancer therapies that help patients across cancer types. However, they face limitations in determining the results of drug effectiveness, as well as ensuring even distribution among all cancer cells because of the highly compact nature of tumors. Researchers are working to change that by giving chemotherapy drugs a kind of chemical "signal" that allows them to be tracked inside of cells.

A new study co-led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center has found that women with early-stage cervical cancer who received radiation plus chemotherapy reported a greater short-term decline in quality of life than those who received radiation alone.