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A new approach to study treatment resistance in high-grade serous ovarian cancer

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  • 2025-10-02 03:31 event
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A new approach to study treatment resistance in high-grade serous ovarian cancer
Several factors make ovarian cancer particularly challenging to treat. This is largely because the cancer often spreads at a microscopic level within the abdomen early on, resulting in diagnosis at an advanced stage. Additionally, while initial treatments with surgery, chemotherapy, and maintenance therapies are successful for many people, most advanced stage ovarian cancers eventually come back.

1. Medical opposition to capital punishment is needed as executions surge, researcher argues

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The health care community has an important role in opposing the death penalty, argues an expert in The BMJ.

2. Commercial sunbeds should be banned in the UK, say experts

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Commercial sunbeds should be banned in the UK, argue experts in The BMJ today.

3. India could bear biggest impact from chikungunya, new maps suggest

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The most comprehensive mapping to date of the global risk of chikungunya suggests India could experience the greatest long-term impact from the mosquito-borne virus.

4. New developmental theory challenges traditional views on childhood trauma memories

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A new developmental theory is reshaping how experts understand the reliability of children's and adolescents' memories of traumatic events and adverse experiences.

5. Why exercise could actually save your heartbeats—not waste them

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Forget the myth that exercise uses up your heartbeats. New Australian research shows fitter people use far fewer total heartbeats per day—potentially adding years to their lives.

6. Protein quality control collapse may explain why cancer immunotherapy fails

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Scientists from The Ohio State University Comprehensive Cancer Center—Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC–James) report key findings about the underlying mechanisms of immune system stress response to protein misfolding, launching a new approach to cancer immunotherapy treatment targeting the protein production cycle.

7. It's time get a flu vaccination. Here's who needs one and why

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It's time to get a flu vaccine, and pediatricians are urging people to get them after last winter, when the U.S. saw the most flu-related child deaths in 15 years.

8. Q&A: What are the best ways to protect against chainsaw injuries?

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Fall is the time of year when thousands of Pennsylvania residents head to forests and woodlots with chainsaws to cut firewood to heat and enhance their homes over the coming winter months.

9. Study reveals surprising attitudes among Ohio primary care providers toward diabetes vs. opioid use disorder treatment

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A recent study published in JAMA Network Open, titled "Health Care Professional Willingness to Treat Opioid Use Disorder vs. Type 2 Diabetes in Primary Care," reveals surprising insights into how primary care providers in Ohio perceive and treat opioid use disorder (OUD) differently from other chronic conditions, such as type 2 diabetes.

10. A new approach to study treatment resistance in high-grade serous ovarian cancer

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Several factors make ovarian cancer particularly challenging to treat. This is largely because the cancer often spreads at a microscopic level within the abdomen early on, resulting in diagnosis at an advanced stage. Additionally, while initial treatments with surgery, chemotherapy, and maintenance therapies are successful for many people, most advanced stage ovarian cancers eventually come back.

11. Older adults with prediabetes and less education face higher cardiovascular complication risk

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It's estimated that nearly half of adults aged 65 and older are living with prediabetes, a condition that predisposes them to developing type 2 diabetes and puts them at higher risk for cardiovascular complications.

12. What the gut microbiome of the world's oldest person can tell us about aging

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When María Branyas Morera died in 2024 at the age of 117, she left more than memories. She left science a gift: samples of her microbiome.

13. Direct-mail HPV self-test kits boost screening rates and are cost-effective, study finds

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New research published in JAMA Network Open finds that mailing human papillomavirus (HPV) self-sampling kits to patients is a cost-effective strategy for increasing cervical cancer screening completion rates. Long-term infection with high-risk HPV strains can cause abnormal cell growth, which could progress to cervical cancer. The study is the first to examine the cost-effectiveness of these mailing strategies across different patient screening histories within a U.S.-based health system.

14. Dengue vaccine shows effectiveness under real-world conditions during Brazil's 2024 outbreak

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An international team of researchers has demonstrated that the tetravalent dengue vaccine known as Qdenga provided significant protection against the disease under real-world conditions, during the large 2024 epidemic in São Paulo, Brazil.

15. An AI tool is trying to predict your risk of getting many diseases years in advance— here's how it works

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Being able to instantly and accurately predict the trajectory of a person's health in the years to come has long been seen as the pinnacle of medicine. This kind of information would have a profound effect on health care systems as a whole—shifting care from treatment to prevention.

16. Tiny flies, big discovery: Brain protein could hold key to healthier aging

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Could the secret to a longer, healthier life be hidden inside the brain of a fruit fly? Researchers at National Taiwan University (NTU) think the answer is yes.

17. Outdoor air exposure to industrial solvent trichloroethylene may raise risk of Parkinson's disease

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Long-term exposure to the industrial solvent trichloroethylene (TCE) outdoors may be linked to an increased risk of Parkinson's disease, according to a large nationwide study published in Neurology.

18. Variations in human donor milk present critical considerations for preterm infants worldwide

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A recent study has revealed significant variations in the nutritional composition of donor human milk across different countries. These findings could transform how hospitals support critically ill preterm infants worldwide.

19. Potential biomarker for the development of long COVID identified

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A research team working at MedUni Vienna has demonstrated that a specific component of the immune system (PTX-3) remains at significantly higher levels in the blood of patients who have suffered from severe COVID-19, even months after the acute infection has subsided. This study identifies PTX-3 as a potential biomarker for existing tissue damage, long-term immune activation and also for complications following COVID-19.

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