AI-guided drug discovery forges a novel therapeutic path for patients with Rett syndrome

Some 25 years ago, a young Parkinson's disease investigator, Robert Hauser, MD, stepped to the podium at an American Academy of Neurology Conference to present findings from his patient survey that didn't quite jibe with classic beliefs. And he was about to discover that it can be hard to stand your ground as a newcomer challenging the status quo.

The lack of reliable information about health facilities across sub-Saharan Africa became very clear during the COVID-19 pandemic. Amid a surge in emergency care needs, information was lacking about the location of facilities, bed capacity and oxygen availability, and even where to find medical specialists. This data could have enabled precise assessments of hospital surge capacity and geographic access to critical care. Peter Macharia and Emelda Okiro, whose research focuses on public health and equity of health service access in low resource settings, share the findings of their recent study, co-authored with colleagues.

Women who see themselves as having lower social status are more likely than other people to show early signs of heart stress linked to future disease risk, according to a new study led by researchers at McGill and Concordia universities.

Continuing to vaccinate for mpox through a routine targeted program for gay and bisexual men delivered by sexual health services will greatly reduce the number of cases and save the NHS millions, new research has found.

Adding targeted radiation to chemotherapy prior to surgery may offer better control of pancreatic tumors—potentially reducing the rate of recurrence after treatment, according to a new study from UT Southwestern Medical Center. Published in Clinical Cancer Research, the novel study offers evidence of a more effective approach with biological insights for treating one of the most aggressive and lethal forms of cancer.

College students who want help overcoming high-risk drinking could benefit from a two-pronged approach that combines an individual-focused psychological theory with social network analysis.

Triclosan is an antimicrobial chemical that was for decades added to everyday items like soap, toothpaste, cosmetics and even kitchen utensils and athletic wear, until concerns about potential health risks led manufacturers to phase it out of some products.

A new hydrogel-based platform to preserve live patient-derived tumor tissues in the lab could pave the way for faster, more accurate testing of cancer treatments for patients with peritoneal metastases, a hard-to-treat and often deadly form of abdominal and pelvic cancers.

A new study from Aarhus University challenges the widespread belief that women are naturally "hardwired" to wake up more easily to a crying baby than men. The work is published in the journal Emotion.

A new study reveals that air pollution, traditional herbal medicines and other environmental exposures are linked to genetic mutations that may contribute to the development of lung cancer in people with no or hardly any history of smoking.

A new study by investigators from Europe, including the Netherlands and the United Kingdom (UK), has shed light on significant ethical, administrative, regulatory, and logistical (EARL) hurdles in delivering multinational randomized clinical trials. The research was the first to comprehensively quantify these barriers for an international platform trial and emphasizes the need for urgent improvements, particularly in preparing for future public health crises.

Chronic inflammation occurs when the immune system is stuck in attack-mode, sending cell after cell to defend and repair the body for months or even years. Diseases associated with chronic inflammation, like arthritis or cancer or autoimmune disorders, weigh heavily on human health—and experts anticipate their incidence is on the rise.

A study published in Cell Stem Cell reveals that some mutations in blood stem cells might help protect against late-onset Alzheimer's disease.

Early recovery from drug addiction to opioids and stimulants is physically and mentally demanding, and a long road to recovery.

Researchers have long been interested in how humans and animals make decisions by focusing on trial-and-error behavior informed by recent information. However, the conventional frameworks for understanding these behaviors may overlook certain realities of decision-making because they assume we make the best decisions after taking into account our past experiences.

A study by researchers at Rutgers Health has uncovered a way to precisely identify and target trauma sites in the body within minutes of injury. The findings, published in the journal Med, could revolutionize emergency care by enabling real-time diagnostics and site-specific treatments delivered within minutes of injury.

Patients with ovarian clear cell carcinoma (OCCC) whose tumors have specific mutations in the PPP2R1A gene were found to have improved survival following immunotherapy compared to patients without these mutations, according to researchers from The University of Texas MD Anderson Cancer Center.

As smartphones, apps, and wearable devices become more integrated into health care, new research from the University of Surrey is questioning how effective these digital tools are for managing serious conditions like cancer, diabetes and heart diseases.