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Blocking a key protein halts lung scarring in mouse model of fibrosis

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  • 2025-10-17 15:58 event
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Blocking a key protein halts lung scarring in mouse model of fibrosis
Pulmonary fibrosis is a deadly disease in which the lungs become thickened and scarred, gradually losing their ability to deliver oxygen to the body. Now, scientists at UC San Francisco have identified a key cellular switch that drives this process—and found a way to block it in mice.

41. Why high levels of lead are found in plant-based protein powders and many brands of cinnamon

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It's no surprise to Northeastern food policy expert Darin Detwiler that high levels of lead are being found in both protein powders and bottles of cinnamon.

42. 'Skinny fat' linked to silent artery damage

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A new study led by researchers at McMaster University reveals that hidden fat deep inside the abdomen and liver may quietly damage arteries, even in people who appear healthy.

43. Should the UK introduce targeted prostate cancer screening? The case for and against

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Former UK prime minister Rishi Sunak has called for a targeted prostate cancer screening program for men most at high risk of the disease, reviving a national debate on how to save more lives and tackle health inequalities among men.

44. When healing turns harmful: Adrenal support cells tied to cancer origin

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A new study from Karolinska Institutet, published in npj Precision Oncology, shows that support cells in the adrenal gland can regenerate hormone-producing tissue after birth. The same cells may also act as a starting point for adrenal tumors, offering new insights into cancer development and potential treatment strategies.

45. Missing molecule holds clues to Down syndrome

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New research suggests a missing brain molecule may hold the key to understanding—and potentially treating—the faulty neural circuits seen in Down syndrome. Restoring the molecule, called pleiotrophin, could enhance brain function in people with Down syndrome and other neurological diseases, even in adulthood, researchers say.

46. Virtual antenatal care linked to poorer pregnancy outcomes

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Women who receive more virtual antenatal care during their second or third trimesters could experience poorer pregnancy outcomes, including higher risks of preterm birth, cesarean sections and neonatal intensive care unit admissions, a new study suggests.

47. High rates of articular cartilage damage found in pediatric athletes after ACL injuries, meniscus tears

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A new study led by Yale School of Medicine's Department of Orthopedics & Rehabilitation unveiled key insights into the knee joint's vulnerability for young athletes who suffer anterior cruciate ligament (ACL) injuries combined with medial meniscus tears.

48. LGBTQ+ community groups fill gaps in youth mental health care

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As LGBTQ+ youth across the U.S. continue to face higher rates of mental health challenges and substance use, community-based organizations (CBOs) are playing an increasingly vital role in providing safe, supportive spaces. Yet, despite their growing importance, these organizations remain largely understudied.

49. Large language models prioritize helpfulness over accuracy in medical contexts, finds study

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Large language models (LLMs) can store and recall vast quantities of medical information, but their ability to process this information in rational ways remains variable. A new study led by investigators from Mass General Brigham demonstrated a vulnerability in that LLMs are designed to be sycophantic, or excessively helpful and agreeable, which leads them to overwhelmingly fail to appropriately challenge illogical medical queries despite possessing the information necessary to do so.

50. Blocking a key protein halts lung scarring in mouse model of fibrosis

  • 2 days ago schedule
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Pulmonary fibrosis is a deadly disease in which the lungs become thickened and scarred, gradually losing their ability to deliver oxygen to the body. Now, scientists at UC San Francisco have identified a key cellular switch that drives this process—and found a way to block it in mice.

51. FDA unveils drugs to receive expedited review in support of 'national priorities'

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The Food and Drug Administration on Thursday announced the first round of experimental drugs that will receive drastically expedited reviews at the agency, part of an effort to prioritize medicines the Trump administration deems as "supporting U.S. national interests."

52. California mpox cases raise concerns. But health officials say the risk remains low

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Two Californians diagnosed with mpox may be the first U.S. cases resulting from the local spread of a different version of the virus, health officials said.

53. Building stronger health systems saves lives, Madagascar experiment shows

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The idea that building better health care systems can improve and save people's lives may seem obvious, but until now there has been little published with the data and statistical muscle to prove it.

54. Cancer cells reactivate embryo-like gene editors to fuel growth, research reveals

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Cancer cells are known to reawaken embryonic genes to grow. A new study reveals the disease also hijacks the proteins, or "editors," that control how those genes are read.

55. In the midst of a global dengue epidemic, one program kept a Brazilian city safe

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Dengue has been a public health problem in the tropical world for decades and 2024 saw a global dengue surge, with more than 14 million cases and 10 thousand deaths reported worldwide—more than double the figures for dengue epidemics previously recorded in 2023 and 2019.

56. The brain may not be a muscle, but it still needs exercise

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As we age, keeping our bodies active helps us stay healthier for longer and protects against chronic disease. We can also exercise our brains to prevent age-related mental decline with activities like reading aloud, writing by hand, and simple math exercises.

57. A 'flight simulator' for the brain reveals how we learn—and why minds sometimes go off course

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Every day, your brain makes thousands of decisions under uncertainty. Most of the time, you guess right. When you don't, you learn. But when the brain's ability to judge context or assign meaning falters, thoughts and behavior can go astray. In psychiatric disorders ranging from attention-deficit/hyperactivity disorder to schizophrenia, the brain may misjudge how much evidence to gather before acting—or fail to adjust when the rules of the world change based on new information.

58. Researchers propose novel solution to U.S. Indian Health Service underfunding

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For many years, the Indian Health Service (IHS) has been underfunded, leading to health and life expectancy disparities among Indigenous people, according to University of Oklahoma researchers. In an article in Health Affairs, OU researchers propose a novel trust fund solution to increase and sustain the funding level, with the ultimate goal of improving health care access and outcomes.

59. New framework can improve the planning stage of surgical quality improvement projects

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New study findings show the vast majority of small-scale quality improvement (QI) projects in surgery suffer from poor planning that can doom the effort from the start. To address this challenge, researchers have developed and tested a new tool, the Early Planning of Small-Scale Surgical Improvement (EPoSSI) framework, to guide surgeons and their teams through a comprehensive planning process.

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